A5051475544- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- Body Composition Measurement Techniques
- Mental Health Treatment and Access
- Liver Disease Diagnosis and Treatment
- Electrical and Bioimpedance Tomography
- Hepatitis C virus research
- Eosinophilic Esophagitis
- Liver Disease and Transplantation
- Adolescent Sexual and Reproductive Health
- Poverty, Education, and Child Welfare
- HIV/AIDS Research and Interventions
- Delphi Technique in Research
- Treatment of Major Depression
- Child and Adolescent Health
- Antifungal resistance and susceptibility
- Health Policy Implementation Science
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Hemodynamic Monitoring and Therapy
- Employment and Welfare Studies
- Cystic Fibrosis Research Advances
- Infrared Thermography in Medicine
- HIV, Drug Use, Sexual Risk
Newcastle University
2024
University Hospital Southampton NHS Foundation Trust
2017-2022
NIHR Southampton Biomedical Research Centre
2018-2022
National Institute for Health Research
2019-2022
University of Southampton
2015-2021
NIHR Southampton Respiratory Biomedical Research Unit
2020
Southampton General Hospital
2020
Salford Royal NHS Foundation Trust
2017
University of Manchester
2017
University of KwaZulu-Natal
2007-2011
The health and demography of the South African population has been undergoing substantial changes as a result rapidly progressing HIV epidemic. Researchers at University KwaZulu-Natal Medical Research Council established Africa Centre for Health Population Studies in 1997 funded by large core grant from Wellcome Trust, UK. Given urgent need high quality longitudinal data with which to monitor these changes, evaluate interventions mitigate impact, demographic surveillance system (DSS) was...
Abstract Background Blood eosinophil measurement is essential for the phenotypic characterization of patients with difficult asthma and in determining eligibility anti‐IL‐5/IL‐5Rα biological therapies. However, assessing such measures over limited time spans may not reveal true underlying eosinophilic phenotype, as treatment, including daily oral corticosteroid therapy, suppresses inflammation intrinsically variable. Methods We interrogated electronic healthcare records Wessex AsThma CoHort...
Background Chronic liver disease is an escalating problem both in the United Kingdom and worldwide. In UK mortality rates have risen sharply over previous 50 years predominantly due to alcohol, however increasing prevalence of non-alcohol related fatty elsewhere also concern. Liver develops silently hence early detection fibrosis essential prevent progression. Primary care presents opportunity identify at risk populations, assessment largely comprises indirect markers which little prognostic...
Asthma is now widely recognised to be a heterogeneous disease. The last two decades have seen the identification of number biological targets and development various novel therapies. Despite this, asthma still represents significant health economic burden worldwide. Why some individuals should continue suffer remains unclear. Wessex Cohort Difficult (WATCH) an ongoing 'real-life', prospective study patients in University Hospital Southampton Foundation Trust (UHSFT) service. Research data...
Summary Objective To investigate the prevalence of social exposure to a large, government‐run ART programme in rural South Africa. Method Clinical data on 6681 patients were matched with demographic nearly complete cohort 102 359 people residing catchment area. We calculated proportion residents surveillance area that members household, or resided compound where someone had initiated received pre‐ART care. Results By January 2010, 3% population ART. However, 25% shared household membership...
Primary ciliary dyskinesia (PCD) is a rare, heterogeneous genetic disorder where impaired mucociliary clearance caused by dysfunctional motile cilia leading to bronchiectasis. There limited evidence characterising the nutritional status of children with PCD, although lower body mass index (BMI) z-score has been associated worse lung function (FEV1).All (n = 43) aged <16 years, from single tertiary centre were prospectively enrolled. Information on clinical phenotype and including...
Abstract Background Exercise is recommended in guidelines for asthma management and has beneficial effects on symptom control, inflammation lung function patients with sub-optimally controlled asthma. Despite this, physical activity levels difficult are often impaired. Understanding the barriers to exercise people crucial increasing their activity, implementing successful, disease modifying, holistic approaches improve health. Methods 62 Patients within WATCH Difficult Asthma Cohort...
Objectives Most patients are unaware they have liver cirrhosis until present with a decompensating event. We therefore aimed to develop and validate an algorithm predict advanced disease (AdvLD) using data widely available in primary care. Design, setting participants Logistic regression was performed on routinely collected blood result from the University Hospital Southampton (UHS) information systems for 16 967 individuals who underwent upper gastrointestinal endoscopy (2005–2016). Data...
<b>Background:</b> Multiple co-morbidities are associated with disease control, healthcare utilization and quality of life in difficult asthma. <b>Aim:</b> To evaluate the prevalence comorbidities patients asthma Wessex AsThma CoHort (WATCH). <b>Methods:</b> Our prospective observation cohort study has enrolled 380 severe History is collected at enrolment. Data presented as percentages chi squared tests were used to calculate differences between groups. <b>Results:</b> *p<0.05...
<b>Background:</b> Improved characterisation of Obese-Asthma phenotypes is the first step to better understanding relationship between these conditions. <b>Aims:</b> To characterise Obese-Difficult Asthma phenotype seen in clinical practice. <b>Methods:</b> We studied patients enrolled (n=380) from a tertiary difficult asthma clinic (Southampton, UK) into longitudinal cohort (WATCH) study. <b>Results:</b> Obesity (BMI>30) was found 47.0% with female predominance (52.3% v 36.8% male;...
<h3>Introduction</h3> In the UK around 9 00 000 people have a diagnosis of COPD. Despite its high prevalence under-diagnosis is common in primary care with an additional 2 million cases suggested. Opportunities for early and intervention are frequently missed. The best strategy targeted case finding unclear. <h3>Methods</h3> ASSIST study (Rec: 15/5C/598580) used previously trialled, computerised case-finding algorithm,<sup>1</sup> applied remotely into systems finding. It applies weighted...
<b>Background:</b> Whether the nature of early-onset difficult adult asthma differs by sex remains unclear. <b>Aim:</b> To assess clinical characteristics in adulthood stratified sex. <b>Method:</b> The Wessex AsThma CoHort (WATCH) at University Hospital Southampton (UHS) UK has enrolled 380 patients from UHS tertiary clinics. We compared between sexes with (age diagnosis ≤18 years). <b>Results:</b> 190 had asthma; 72.1% female (F) and 27.9% male (M). Median age (F vs M) was 5.0 yrs v 3.0...
<b>Background:</b> Phenotypic differences between early-onset (EODA) and adult-onset (AODA) difficult asthma in adulthood are not well described. <b>Aim:</b> To characterise EODA AODA asthma. <b>Methods:</b> The Wessex AsThma CoHort of (WATCH) is a longitudinal study at University Hospital Southampton (UHS) UK set up 2015. date, 380 patients enrolled from the UHS tertiary clinic. Clinical features (age ≤18 yrs) >18 presented here. <b>Results:</b> Of 368 with available data, 51.6% had...
<b>Background:</b> Atopic sensitization represents one of the most recognisable characteristics associated with asthma but its role within difficult adult cohort is less understood. <b>Aim:</b> To evaluate prevalence atopy patients in Wessex AsThma CoHort (WATCH). <b>Methods:</b> Skin prick data available from 314 currently enrolled into this prospective observational study. Atopy was defined as a positive skin test to panel common aeroallergens (mould, pollen, dust mites, feathers and pet...
<b>Background:</b> Eosinophilic inflammation predisposes to poor asthma control, exacerbations and airway remodelling. However, the stability variability of blood eosinophils in a real-life difficult clinic population remain unknown despite its use determine anti-IL5 agent eligibility. <b>Aim:</b> To evaluate WATCH cohort: longitudinal cohort patients with treated at BTS Step 4/5. <b>Methods:</b> Clinically requested tests from were reviewed. These evaluated used k means cluster analysis...