A5056481765- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Diet, Metabolism, and Disease
- Immune Cell Function and Interaction
- Alcohol Consumption and Health Effects
- Hepatitis B Virus Studies
- Pancreatitis Pathology and Treatment
- Diet and metabolism studies
- Diabetes Treatment and Management
- Liver Diseases and Immunity
- T-cell and B-cell Immunology
- Nutritional Studies and Diet
- Hepatocellular Carcinoma Treatment and Prognosis
- Consumer Attitudes and Food Labeling
- Folate and B Vitamins Research
- Patient Satisfaction in Healthcare
- Bone health and treatments
- Sepsis Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Healthcare Quality and Management
- Bone and Joint Diseases
- Substance Abuse Treatment and Outcomes
- Clinical practice guidelines implementation
- Nutrition, Genetics, and Disease
University of Liverpool
2021-2025
Aintree University Hospitals NHS Foundation Trust
2021-2025
Liverpool Heart and Chest Hospital
2024
Liverpool John Moores University
2024
University of Plymouth
2023
Queen Mary University of London
2023
Newcastle upon Tyne Hospitals NHS Foundation Trust
2023
Freeman Hospital
2023
Peninsula Health
2023
National Health Service
2021-2023
Process mapping enables the reconfiguring of patient journey from patient's perspective in order to improve quality care and release resources. This paper provides a practical framework for using this versatile simple technique hospital.
In contrast to our knowledge about the number of cancers attributed smoking, alcohol is poorly understood by public. We estimate increase in absolute risk cancer (number cases per 1000) moderate levels alcohol, and compare these low creating a 'cigarette-equivalent population harm'. Alcohol tobacco attributable fractions were subtracted from lifetime general risks developing alcohol- smoking-related cancers, alcohol-abstaining non-smokers. This was multiplied relative drinking ten units or...
Chronic kidney disease (CKD) and non-alcoholic fatty liver (NAFLD) frequently co-exist. We assess the impact of having NAFLD on adverse clinical outcomes all-cause mortality for people with CKD.A total 18,073 UK Biobank participants identified to have CKD (eGFR < 60 ml/min/1.73 m2 or albuminuria > 3 mg/mmol) were prospectively followed up by electronic linkage hospital death records. Cox-regression estimated hazard ratios (HR) associated (elevated hepatic steatosis index ICD-code) fibrosis...
We examined the impact of a co-diagnosis metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes (T2D) on patient outcomes.
The aim of this study was to determine whether liver fibrosis is associated with heart failure in a general population cohort, and if genetic polymorphisms (PNPLA3 rs738409; TM6SF2 rs58542926), linked increased risk decreased coronary artery disease, modify association.
Murine hepatic NK cells exhibit adaptive features, with liver-specific adhesion molecules CXCR6 and CD49a acting as surface markers.We investigated human liver-resident CXCR6+ CD49a+ using RNA sequencing, flow cytometry, functional analysis. We further assessed the role of cytokines in generating these phenotypes from peripheral blood.Hepatic could be induced produce high quantities IFNγ TNFα, contrast to cells. sequencing confirmed a tolerant immature phenotype reduced expression markers...
Background Upper gastrointestinal (UGI) endoscopy is a routine healthcare procedure with defined patient pathway. The objective of this study was to redesign pathway for unsedated patients using lean thinking transformation focus on patient-derived value-adding steps, remove waste and create more efficient process. This form the basis template that transferrable other units. Methods A literature search expectations UGI identified value. value stream map created current minimum maximum time...
The COVID-19 pandemic has reduced physical activity (PA) levels. This is important as inactivity linked to poor outcomes. study aimed assess the impact of restrictions on greenspace and residence mobility, walking levels in turn how these translated trends (UK) PA levels.Google Mobility Reports, Oxford Government Response Tracker Apple geospatial datasets were interrogated for international data. Residence mobility represents home includes parks, direction requests proportion directions;...
The clinical impact of Nonalcoholic fatty liver disease(NAFLD) in patients with atrial fibrillation(AF) is still controversial.
Objective. Understanding patients' attitudes to their medical experience is essential for identifying value in the patient pathway, optimizing care and use of resources. This service evaluation was undertaken determine preferences expectations day case colonoscopy, a common gastrointestinal procedure which there limited such data. Methods. Patients attending elective colonoscopy were invited complete composite, validated dedicated endoscopy questionnaire, with Likert-scale questions 15-point...
Natural killer (NK) cells are important mediators of liver inflammation in chronic disease. The aim this study was to investigate why transplants (LTs) not rejected by NK the absence human leukocyte antigen (HLA) matching, and identify a tolerogenic cell phenotype.Phenotypic functional analyses on from 54 LT recipients were performed, comparisons made with healthy controls. Further investigation performed using gene expression analysis donor:recipient HLA typing.NK non-HCV hypofunctional,...
Abstract Background Polycystic ovary syndrome (PCOS) is associated with adverse clinical outcomes that may differ according to PCOS phenotype. Methods Using UK Biobank data, we compared the incidence of type 2 diabetes (T2D), metabolic dysfunction steatotic liver disease, cardiovascular disease (CVD), hormone-dependent cancers, and dementia between participants age- body mass index-matched controls. We also multiorgan (liver, cardiac, brain) magnetic resonance imaging (MRI) data examined...