A5077886592- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- Asthma and respiratory diseases
- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Medical Imaging and Pathology Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Immune cells in cancer
- Sarcoidosis and Beryllium Toxicity Research
- Intensive Care Unit Cognitive Disorders
- Eosinophilic Disorders and Syndromes
- Inhalation and Respiratory Drug Delivery
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Venous Thromboembolism Diagnosis and Management
- Respiratory Support and Mechanisms
- Pleural and Pulmonary Diseases
- Glycosylation and Glycoproteins Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Galectins and Cancer Biology
- Global Healthcare and Medical Tourism
- Eosinophilic Esophagitis
- Patient Satisfaction in Healthcare
- Colorectal Cancer Screening and Detection
Howard University
2024
Australia and New Zealand Banking Group
2024
University College London Hospitals NHS Foundation Trust
2018-2023
University College London
2017-2023
London Chest Hospital
2022
Centre for Inflammation Research
2017-2020
University College Hospital
2019-2020
Royal London Hospital
2017
Queen Alexandra Hospital
2013
Portsmouth Hospitals NHS Trust
2012
Omalizumab treats chronic rhinosinusitis with nasal polyps
Chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma often coexist thus treating both one intervention is an attractive strategy.To prospectively evaluate whether treatment the monoclonal antibody against IgE Omalizumab for severe allergic also effectively treats co-existent CRSwNP.SNOT-22 ACQ-7 scores were recorded at 4 16 weeks of in a cohort patients CRSwNP refractory treated (n=13) according to UK guidelines their asthma. SNOT-22 surgery only group (n=24) was compared.Rapid...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with poor prognosis and significant unmet medical need. This study evaluated the safety, pharmacokinetics (PK) target engagement in lungs, of GSK3008348, novel inhaled alpha-v beta-6 (αvβ6) integrin inhibitor, participants IPF. Methods was phase 1b, randomised, double-blind (sponsor unblind) study, conducted UK (two clinical sites, one imaging unit) between June 2017 July 2018 (NCT03069989)....
There is growing recognition that mucus and mucin biology have a considerable impact on respiratory health, subsequent global morbidity mortality. Mucins play critical role in chronic lung disease, not only by providing physical barrier clearing pathogens, but also immune homeostasis. The aim of this review to familiarise the reader with mucins both health particular focus function immunity, infection inflammation. We will discuss their receptors, termed glycan-binding proteins, how they...
Objective. Understanding patients' attitudes to their medical experience is essential for identifying value in the patient pathway, optimizing care and use of resources. This service evaluation was undertaken determine preferences expectations day case colonoscopy, a common gastrointestinal procedure which there limited such data. Methods. Patients attending elective colonoscopy were invited complete composite, validated dedicated endoscopy questionnaire, with Likert-scale questions 15-point...
Neutrophilic inflammation correlates with mortality in fibrotic interstitial lung disease (ILD) however, the underlying mechanisms remain unclear. Neutrophil function is modulated by numerous factors, including integrin activation, inflammatory cytokines and hypoxia. Hypoxia has an important role may also contribute to pulmonary disease. We aimed determine how neutrophil activation occurs ILD relative importance of Using biopsies bronchoalveolar lavage (BAL) fluid from patients we...
Transforming growth factor-β1 (TGFβ1) is the key profibrotic cytokine in idiopathic pulmonary fibrosis (IPF), but primary source of this disease unknown. Platelets have abundant stores TGFβ1, although role these cells IPF ill-defined. In study, we investigated whether platelets, and specifically platelet-derived mediate progression. Patients with non-IPF patients were recruited to determine platelet reactivity, separate cohorts followed for mortality. To study TGFβ1 modulates (PF), mice a...
Background: Chronic rhinosinusitis with and without nasal polyps (CRSwNP CRSsNP respectively) can be difficult to treat biologics offer potential as a future therapeutic intervention.CRS severe asthma often co-exist.Omalizumab is currently licenced for the treatment of allergic asthma.Objective: The aim was determine which blood biomarkers variables were associated clinical response sinonasal symptoms in patients CRSwNP who treated omalizumab asthma.Methods: Sinonasal outcome test (SNOT)-22...
<h3>Introduction</h3> IPF is a heterogeneous disease, and, due to the absence of predictive biomarkers, prognostic estimates rely on clinical scoring systems such as GAP (Gender, Age, Physiology). As relatively 'static', additional biomarkers are needed for more accurate prediction disease progression and therapeutic response. Neutrophil: Lymphocyte ratio (NLR) has been shown be value in cancer inflammatory pathologies but never investigated IPF. <h3>Methods</h3> The optimal NLR cut-off was...
Abstract Background Metabolic diseases like chronic Type 2 Diabetes Mellitus (T2DM) are now a serious global health concern In the United States. African Americans (AA) being affected at disproportionate rate with condition compared to other ethnic groups, yet there relatively few studies that have specifically focused on this group. Our previous findings suggested AA patients T2DM had gene expression signals associated Alzheimer’s Disease (AD). The current pilot study aimed examine...
<b>Rationale:</b> GSK3008348 is an inhaled αvβ6 integrin inhibitor. Here we present the results of a randomised, placebo-controlled, single dose phase Ib study (204715, NCT03069989) to demonstrate pulmonary target engagement in IPF patients, assessed by dynamic positron emission tomography (PET) using radiolabelled αvβ6-specific ligand, [18F]-FBA-A20FMDV2. <b>Methods:</b> Participants with received 1mg or placebo ratio 5:2. Safety, tolerability, PK and PET-derived were assessed. The primary...
Chronic rhinosinusitis (CRS) with severe asthma are associated breathing pattern disorder (BPD). Mouth is a sign of disorder, and nose fundamental part retraining for BPD. The prevalence BPD in relation to CRS subtypes the relationship nasal obstruction unknown. assessment tool (BPAT) can identify Our objective was thus investigate BPD, airflow measures airway disease severity (CRSwNP) without polyps (CRSsNP) asthma.
Currently the only available therapies for fibrotic Interstitial Lung Disease are administered systemically, often causing significant side effects. Inhaled therapy could avoid these but to date there is no evidence that drug can be effectively delivered distal, fibrosed lung. We set out combine mass spectrometry and histopathology with rapid sample acquisition using transbronchial cryobiopsy determine whether an inhaled fibrotic, distal lung parenchyma in participants Disease. Patients...
<b>Introduction:</b> In 2009, only 40% of men and 28% women met NICE recommendations for physical activity (PA) in England. The health benefits PA are significant well recognised, but the consequences inactivity have not been investigated asthma. A systematic review hypothesized that breathlessness, asthma control fear exertion triggering symptoms were barriers to PA. <b>Aims objectives:</b> To determine levels a Severe Asthma (SA) population identify reported exercise. <b>Method:</b>...
Abstract Neutrophilic inflammation correlates with mortality in fibrotic interstitial lung disease (ILD) however, the underlying mechanisms remain unclear. We aimed to determine whether aberrant neutrophil activation is a feature of ILD and relative role hypoxia. used biopsies bronchoalveolar lavage (BAL) from patients investigate extent hypoxia lungs ILD. complemented these findings ex vivo functional studies neutrophils healthy volunteers effects demonstrate for first time HIF-1α staining...
<b>Introduction:</b> Mediastinal lymphadenopathy is a common feature in patients with IPF. We investigated the relationship between node avidity and survival. <b>Aim:</b> To assess significance of FDG uptake nodes IPF undergoing PET imaging. <b>Materials Methods:</b> 92 were recruited prospectively. nodal was measured as SUV<sub>max</sub>, SUV<sub>min</sub>, TBR (SUV<sub>max</sub>/SUV<sub>min</sub>). Kaplan Meier survival analysis used to investigate overall avid non-avid cohorts....
<h3>Introduction</h3> Understanding patient attitudes to their medical experience is essential for optimising care and use of resources. This includes interaction with health practitioner healthcare environment. study was undertaken determine patient9s preferences expectations outpatient colonoscopy, a common gastrointestinal procedure which there limited such data from the UK. <h3>Methods</h3> Unselected patients attending elective colonoscopy at large District General Hospital on randomly...
<h3>Background</h3> Neutrophilic inflammation is common in various diseases and may contribute to the pathophysiology of interstitial lung disease (ILD), however underlying mechanism are not fully understood. Localised tissue hypoxia often accompanied with inflammation, which alter cellular responses drive immunopathology. <h3>Hypothesis</h3> We propose that modulates neutrophil functions including integrin activation, extravasation extracellular trap (NET) release pulmonary damage ILD...
<h3>Introduction</h3> The Interstitial Lung Diseases (ILD) are a heterogeneous group of inflammatory and fibrotic diseases the interstitium, with worst cases resulting in pulmonary fibrosis (PF). Increased neutrophils found within lung or bronchoalveolar lavage (BAL) ILD predict poor prognosis. Neutrophil adhesion molecules, e.g., CD18/b2 integrins (LFA-1; CD11a, Mac-1; CD11b CR3; CD11c) L-Selectin (CD62L) regulate cellular recruitment animal models bleomycin-induced PF. Expression Fc...
<b>Intro:</b> In a trial omalizumab controlled symptoms and polyp size in chronic rhinosinusitis with nasal polyps (CRSwNP), but effects on patients treated for severe asthma are not described. <b>Aim:</b> We assessed outcomes our cohort receiving omalizumab, either CRSwNP or perennial allergic rhinitis (PAR), using sinonasal outcome test (SNOT 22). <b>Method:</b> Patients had SNOT, spirometry, ACQ, AQLQ FeNO (FeNO) 4-weekly up to their 16-week assessment of treatment efficacy....