A5056591428- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Health, Environment, Cognitive Aging
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Folate and B Vitamins Research
- Endoplasmic Reticulum Stress and Disease
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Dementia and Cognitive Impairment Research
- Liver Diseases and Immunity
Howard University
2022-2024
Background: Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder that most prevalent in elderly individuals, especially developed countries, and its prevalence now increasing developing countries like Pakistan. Objective: Our goal was to characterize key genes their levels of expression related molecular transcriptome networks associated with AD pathogenesis pilot case-control study Pakistani population. Methods: To obtain the spectrum patients Pakistan (comparing cases...
Metabolic-dysfunction-associated steatotic liver disease (MASLD) is becoming the most common chronic worldwide and of concern among African Americans (AA) in United States. This pilot study evaluated differential gene expressions identified signature genes pathways AA individuals with MASLD. Blood samples were obtained from MASLD patients (n = 23) non-MASLD controls 24) along their sociodemographic medical details. Whole-blood transcriptomic analysis was carried out using Affymetrix...
Abstract Aims African Americans (AA) in the United States have a high risk of type 2 diabetes mellitus (T2DM) and suffer from disparities prevalence, mortality, comorbidities disease compared to other Americans. The present study aimed shed light on molecular mechanisms pathogenesis T2DM among AA Washington, DC region. Methods We performed TaqMan Low Density Arrays (TLDA) 24 genes interest that belong three categories: metabolic disorders , cancer‐ related genes, neurobehavioural genes. 18...
Abstract Background Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Developing countries will have >3 times prevalence developed by year 2050. Our previous studies with a Pakistani population suggested that type 2 diabetes mellitus (T2DM) strongly associated impaired cognitive functioning, and genetic pathways showed strong resemblance to known AD patterns. The present case investigated two important pathways, i.e., Amyloid Precursor Protein (APP) processing Lipid...
Abstract Background Metabolic diseases like chronic Type 2 Diabetes Mellitus (T2DM) are now a serious global health concern In the United States. African Americans (AA) being affected at disproportionate rate with condition compared to other ethnic groups, yet there relatively few studies that have specifically focused on this group. Our previous findings suggested AA patients T2DM had gene expression signals associated Alzheimer’s Disease (AD). The current pilot study aimed examine...