A5091749351- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- RNA modifications and cancer
- Health, Environment, Cognitive Aging
- Toxic Organic Pollutants Impact
- Cancer-related molecular mechanisms research
- Bioinformatics and Genomic Networks
- Alzheimer's disease research and treatments
- Bacteriophages and microbial interactions
- Heavy Metal Exposure and Toxicity
- Nutrition, Genetics, and Disease
- Phagocytosis and Immune Regulation
- Fish Biology and Ecology Studies
- Folate and B Vitamins Research
- Genomics and Phylogenetic Studies
- Aquaculture Nutrition and Growth
- MicroRNA in disease regulation
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cytokine Signaling Pathways and Interactions
- Marine Bivalve and Aquaculture Studies
- Immune cells in cancer
- Prostate Cancer Treatment and Research
- Computational Drug Discovery Methods
Howard University
2013-2024
Children's National
2009
Slovak Medical University
2009
University of California, Davis
2009
Bose Institute
1998
Antineoplastic agents often achieve antitumor activity at the expense of close to unacceptable toxicity. One potential avenue improve therapeutic index might combine targeting distinct components same growth regulatory pathway. This lead more complete modulation target pathway concentrations lower than those associated with limiting adventitious toxicities from either agent alone. The protein kinase antagonist UCN-01 is currently used in Phase I/II trials and has recently been demonstrated...
African American (AA) men have the highest incidence and mortality rate from Prostate cancer (PCa) than any other racial/ethnic group. To date, PCa genomic studies largely under-represented tumour samples AA men. We measured genome-wide DNA methylation in benign tumor prostate tissues using Illumina Infunium 850 K EPIC array. mRNA expression database a subset of biospecimen were used to assess correlation transcriptome datasets. Genome-wide analysis identified 11,460 probes that significant...
Background: Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder that most prevalent in elderly individuals, especially developed countries, and its prevalence now increasing developing countries like Pakistan. Objective: Our goal was to characterize key genes their levels of expression related molecular transcriptome networks associated with AD pathogenesis pilot case-control study Pakistani population. Methods: To obtain the spectrum patients Pakistan (comparing cases...
Though many cancers are known to show up-regulation of nonmuscle myosin (NM) IIA and IIB, the mechanism by which NMIIs aid in cancer development remains unexplored. Here we demonstrate that tumor-generating, fibroblast-like cells isolated from 3-methylcholanthrene (3MC)-induced murine tumor exhibit distinct phospho-dependent localization NMIIA NMIIB at perinuclear area tip filopodia affect cell migration differentially. While NMIIA-KD affects protrusion dynamics increases directionality,...
Polychlorinated biphenyls (PCBs) are a group of persistent and widely distributed environmental pollutants that have various deleterious effects, e.g., neurotoxic, endocrine disruption reproductive abnormalities, including cancers. Chronic exposure to environmentally hazardous chemicals like PCBs is great concern human health. It has been reported earlier apoptotic proteins change in rats under chronic PCB treatment. importance determine if chronically exposed cells develop different protein...
The epidemic of type 2 diabetes mellitus (T2DM) and the possibility it contributing to risk Alzheimer's disease (AD) have become important health concerns worldwide in Pakistan, where co-occurrence T2DM AD is becoming more frequent. To gain insights on this phenomenon, a cross-sectional study was initiated. We recruited interviewed 820 research participants from four cities Pakistan: 250 controls, 450 T2DM, 100 AD, 20 with both diseases. Significant differences between groups were observed for age (
Metabolic-dysfunction-associated steatotic liver disease (MASLD) is becoming the most common chronic worldwide and of concern among African Americans (AA) in United States. This pilot study evaluated differential gene expressions identified signature genes pathways AA individuals with MASLD. Blood samples were obtained from MASLD patients (n = 23) non-MASLD controls 24) along their sociodemographic medical details. Whole-blood transcriptomic analysis was carried out using Affymetrix...
Polychlorinated biphenyls (PCBs) are among the most widespread and persistent pollutants in global environment. Coplanar noncoplanar PCBs have been shown to cause congener-specific apoptosis mediated neurotoxicity rats. Very few, if any, such studies reported on human renal cell toxicity. The authors report here caspase-dependent or caspase-independent toxicity, as measured by apoptotic death induced PCBs, depending planarity of congeners PCB-77 (coplanar) PCB-153 (noncoplanar) kidney cells...
Abstract The puffer fishes Chelonodon patoca, Sphaeroides oblongus, Lagocephalus lunaris , and L. inermis of Indian coastal waters are wasted in huge quantity. livers these were investigated for their lipid contents fatty acid compositions different seasons. It was found that monsoon season is the suitable time to obtain maximal lipids (40.1–48.8%) from livers, an amount similar cod liver content (39.5–55.0%). acids mostly saturates monoenes (60–70%). Eicosapentaenoic (EPA) docosahexaenoic...
Earlier, we have reported that Polychlorinated Biphenyls (PCBs) exposure in Slovak population has made differential gene expression linked to the possibilities of some diseases and disorder development studied population. Here report down-regulation LEPR (Leptin receptor) 45-month children may been following consequences developing obesity later life. A pilot high-throughput qRT-PCR [Taqman Low Density Array (TLDA)] study a small also corroborated gene-expression results, their pathways...
The epidemic of type 2 diabetes mellitus (T2DM) is an important global health concern. Our earlier epidemiological investigation in Pakistan prompted us to conduct a molecular decipher the differential genetic pathways this condition relation non-diabetic controls. microarray studies gene expression were conducted on Affymetrix platform using Human Genome U133 Plus 2.0 Array along with Ingenuity Pathway Analysis (IPA) associate affected genes their canonical pathways. High-throughput qRT-PCR...
Abstract Aims African Americans (AA) in the United States have a high risk of type 2 diabetes mellitus (T2DM) and suffer from disparities prevalence, mortality, comorbidities disease compared to other Americans. The present study aimed shed light on molecular mechanisms pathogenesis T2DM among AA Washington, DC region. Methods We performed TaqMan Low Density Arrays (TLDA) 24 genes interest that belong three categories: metabolic disorders , cancer‐ related genes, neurobehavioural genes. 18...