A5066826733- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Extracellular vesicles in disease
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Alzheimer's disease research and treatments
- Diabetes Management and Education
- Neurological and metabolic disorders
- Diabetes Treatment and Management
- Growth Hormone and Insulin-like Growth Factors
- Diabetes and associated disorders
- Genetic factors in colorectal cancer
- Hormonal Regulation and Hypertension
- Complementary and Alternative Medicine Studies
- Pancreatic function and diabetes
- Bone health and osteoporosis research
- Circular RNAs in diseases
- Regulation of Appetite and Obesity
- Gastric Cancer Management and Outcomes
- Metabolism and Genetic Disorders
- Adipose Tissue and Metabolism
- Folate and B Vitamins Research
- Chronic Disease Management Strategies
- Adrenal Hormones and Disorders
Howard University
2014-2024
Howard University Hospital
2005-2023
NewYork–Presbyterian Brooklyn Methodist Hospital
2005
Obesity has become one of the leading public health concerns in United States and worldwide. While obesity is associated with metabolic syndrome, some obese individuals do not possess constellation abnormalities are referred to as metabolically healthy but (MHO) persons. Limited data exist on prevalence characteristics MHO African Americans. The authors studied 126 Americans defined phenotype an individual a body mass index ≥30 kg/m(2) , high-density lipoprotein cholesterol ≥40 mg/dL,...
Obesity is associated with the activation of molecular pathways that increase risk colorectal cancer. Increasing body mass index may accelerate development adenomatous polyps, antecedent lesion The aim this study was to assess BMI effect on colonic polyp and adenoma in African-American.
Objective: The study aim determined if low 25-hydroxy vitamin D levels correlated with of adiponectin and insulin resistance in African American adolescents body mass index ≥85th%.
Background: Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder that most prevalent in elderly individuals, especially developed countries, and its prevalence now increasing developing countries like Pakistan. Objective: Our goal was to characterize key genes their levels of expression related molecular transcriptome networks associated with AD pathogenesis pilot case-control study Pakistani population. Methods: To obtain the spectrum patients Pakistan (comparing cases...
Diabetes mellitus is associated with a wide variety of rheumatologic manifestations which can significantly affect patient's quality life. One these includes diabetic cheiroarthropathy (DCA) affects the hands. We review case 28-year-old female patient type 1 diabetes who was diagnosed DCA after complaining limited movements all joints in her hands and tightening skin. examine how diagnosis made, treatment administered, successful clinical outcome. Clinicians should be able to identify treat...
In 2011, the Centers for Medicare & Medicaid Services (CMS) launched Competitive Bidding Program (CBP) in nine markets diabetes supplies. The intent was to lower costs consumers. claims data (2009-2012) were used confirm CMS report (2012) that there no disruptions acquisition caused by CBP and changes health outcomes.The study population consisted of insulin users: 43,939 beneficiaries test (TEST) 485,688 nontest (NONTEST). TEST NONTEST subdivided: those with full self-monitoring blood...
Article Growth Hormone Deficiency in Patients with Sickle Cell Disease and Failure was published on April 1, 2004 the journal Journal of Pediatric Endocrinology Metabolism (volume 17, issue 4).
Vitamin B12 deficiency results in neuropsychiatric, hematologic, gynecologic, cardiovascular, and cutaneous manifestations. It is seen most commonly the elderly, malabsorption diseases (>60% of all cases), vegans, vegetarians. Manifestations pernicious anemia may be similar to Addison disease lead a misdiagnosis. Herein, we report two cases vitamin which clinical features shared many similarities with disease. Both patients presented progressive darkening hands postural hypotension that...
The potential role of adiponectin, leptin, IGF-1, and tumor necrosis factor alpha (TNF-α) as biomarkers in colorectal adenoma is not clear. Therefore, we aimed to investigate the blood serum levels these adenoma. case-control study consisted from 180 African American patients with colon (cases) 198 healthy Americans (controls) at Howard University Hospital. We used ELISA for TNF-α detection quantification. Statistical analysis was performed by t-test multivariate logistic regression....
The epidemic of type 2 diabetes mellitus (T2DM) and the possibility it contributing to risk Alzheimer's disease (AD) have become important health concerns worldwide in Pakistan, where co-occurrence T2DM AD is becoming more frequent. To gain insights on this phenomenon, a cross-sectional study was initiated. We recruited interviewed 820 research participants from four cities Pakistan: 250 controls, 450 T2DM, 100 AD, 20 with both diseases. Significant differences between groups were observed for age (
Metabolic-dysfunction-associated steatotic liver disease (MASLD) is becoming the most common chronic worldwide and of concern among African Americans (AA) in United States. This pilot study evaluated differential gene expressions identified signature genes pathways AA individuals with MASLD. Blood samples were obtained from MASLD patients (n = 23) non-MASLD controls 24) along their sociodemographic medical details. Whole-blood transcriptomic analysis was carried out using Affymetrix...
The epidemic of type 2 diabetes mellitus (T2DM) is an important global health concern. Our earlier epidemiological investigation in Pakistan prompted us to conduct a molecular decipher the differential genetic pathways this condition relation non-diabetic controls. microarray studies gene expression were conducted on Affymetrix platform using Human Genome U133 Plus 2.0 Array along with Ingenuity Pathway Analysis (IPA) associate affected genes their canonical pathways. High-throughput qRT-PCR...
Abstract Aims African Americans (AA) in the United States have a high risk of type 2 diabetes mellitus (T2DM) and suffer from disparities prevalence, mortality, comorbidities disease compared to other Americans. The present study aimed shed light on molecular mechanisms pathogenesis T2DM among AA Washington, DC region. Methods We performed TaqMan Low Density Arrays (TLDA) 24 genes interest that belong three categories: metabolic disorders , cancer‐ related genes, neurobehavioural genes. 18...
Objective: MicroRNAs (miRNA) are novel critical regulators of cell proliferation and human disease, including diabetes mellitus cancer. The aim this study was to evaluate the expression circulating erythrocytes (E) miRNA-144 miRNA-451 in African Americans Adults (AAA) as a biomarker aging. Methods: blood samples were collected from healthy controls [n=9] following an 8-12 hours fast. Erythrocytes purified twice by Boyum gradient. further sub-fractionated into young (y) (1.07-1.09 g/ml), mid...