A5101436368- Thyroid Cancer Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Garlic and Onion Studies
- Cardiovascular Health and Disease Prevention
- Autophagy in Disease and Therapy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Obesity, Physical Activity, Diet
- Ferroptosis and cancer prognosis
- S100 Proteins and Annexins
- Endoplasmic Reticulum Stress and Disease
- Biomarkers in Disease Mechanisms
- Cardiovascular Health and Risk Factors
- Chemotherapy-induced organ toxicity mitigation
- Curcumin's Biomedical Applications
- Thyroid and Parathyroid Surgery
- Cardiovascular Disease and Adiposity
- Cancer, Hypoxia, and Metabolism
- Sodium Intake and Health
- Birth, Development, and Health
- Nutritional Studies and Diet
- Ion channel regulation and function
- Ion Channels and Receptors
- Heart Rate Variability and Autonomic Control
- Lipoproteins and Cardiovascular Health
- Pomegranate: compositions and health benefits
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology
2020-2025
Howard University
1994-2019
Jiangnan University
2017-2019
State Key Laboratory of Food Science and Technology
2019
Ministry Of Health
2018
Howard University Hospital
2003-2012
National Heart Lung and Blood Institute
2005
National Institutes of Health
2005
National Institute of Neurological Disorders and Stroke
1992
Background: Thyroid cancer is the most common endocrine tumor. Our previous studies have demonstrated that curcumin can induce apoptosis in human papillary thyroid carcinoma BCPAP cells. However, underlined mechanism has not been clearly elucidated. Endoplasmic reticulum (ER) a major organelle for synthesis, maturation, and folding proteins as well large store Ca2+. Overcoming chronically activated ER stress by triggering pro-apoptotic pathways of unfolded protein response (UPR) novel...
The objective of our research was to evaluate the molecular mechanism anti-inflammatory effects surface-layer protein (Slp) derived from Lactobacillus acidophilus NCFM in lipopolysaccharide-induced RAW264.7 cells. Our results presented that Slp, with an apparent size 46 kDa, attenuated production TNF-α, IL-1β, and reactive oxygen species (ROS), by inhibiting MAPK NF-κB signaling pathways. In addition, 10 μg mL–1 Slp significantly inhibited NO PGE2 (P < 0.001) through downregulating...
Background African Americans suffer from disproportionately high rates of hypertension and cardiovascular disease. Psychosocial stress, lifestyle telomere dysfunction contribute to the pathogenesis This study evaluated effects stress reduction modification on blood pressure, telomerase gene expression factors in Americans. Methods Forty-eight American men women with stage I who participated a larger randomized controlled trial volunteered for this substudy. These subjects either...
Capsaicin inhibits metastasis of human papillary thyroid carcinoma BCPAP cells through modulation the TRPV1 channel.
Objective The objective of this study is to investigate the risk and prognostic factors for radioactive iodine (RAI)-refractory (RAIR) differentiated thyroid cancer (DTC) with distant metastasis. Methods A total 128 patients metastasis-DTC who underwent iodine-131 radiotherapy were included in cohort study. After exclusion, 75 DTC resistant radioiodine therapy 53 whom treatment was successful finally included. Clinical data as well BRAF V600E telomerase reverse transcriptase (TERT) promoter...
BRAF V600E is the most common mutation identified in thyroid cancers. However, relationship between and metabolic reprogramming cancer unclear. Here, we investigate mechanism of by constructing V600E-overexpressing BRAF-knockdown cell lines for use mitochondrial respiration glycolysis experiments. Western blot RT-qPCR were performed to measure level metabolism-related proteins, various approaches used transcriptional regulation. In cells, overexpression inhibited OXPHOS gene expression but...
Anaplastic thyroid cancer (ATC) is the most aggressive human malignancy, characterized by dedifferentiation and resistance to radioiodine therapy. The underlying mechanisms regulating ATC are largely unknown. Here, we show that REGγ, a noncanonical proteasome activator highly expressed in ATC, an important regulator of differentiation cells. Ablation REGγ significantly restored expression thyroid-specific genes, enhanced iodine uptake, improved efficacy 131I therapy xenograft models....
Obesity has become one of the leading public health concerns in United States and worldwide. While obesity is associated with metabolic syndrome, some obese individuals do not possess constellation abnormalities are referred to as metabolically healthy but (MHO) persons. Limited data exist on prevalence characteristics MHO African Americans. The authors studied 126 Americans defined phenotype an individual a body mass index ≥30 kg/m(2) , high-density lipoprotein cholesterol ≥40 mg/dL,...
DATS induces G2/M cell-cycle arrest and apoptosis through ATM-Chk1-Cdc25C signaling pathway in ATC 8505C cells.
Objective Pulse pressure, a marker of arterial vascular properties, has been linked to cardiovascular diseases and complications. This study examined the impact excess body mass disease risk factors on pulse pressure (PP). Design Cross-sectional prospective study. Methods Baseline data consist 219 obese African Americans, with mean ± SD age 46.8 10.9 years enrolled in diet exercise program weight reduction. A non-invasive monitoring device was used acquire 24 hourly ambulatory blood...
This study aimed to elucidate the potential effects of diallyl trisulfide (DATS) on human papillary-thyroid-carcinoma BCPAP cells and its underlying mechanisms. DATS is an organosulfur compound derived from garlic. In this study, we demonstrated that compared with solvent control, treatment at concentrations 5, 10, 20 μΜ decreased cell survival rates 84.51 ± 2.67, 57.16 1.18, 41.22 1.19% respectively. also caused cell-cycle arrest G0/G1 phase, proportion arrested in phase rose 68.8 8.38 80.4...
A surface-layer protein (Slp) derived from Lactobacillus acidophilus NCFM has been reported to possess multiple biological properties, including anti-inflammatory, inhibition of apoptosis in pathogen-invaded HT-29 cells and oxidative stress relief. However, its anti-tumor ability underlying molecular mechanism are unknown. Here, we report that Slp suppresses cell proliferation induces autophagic death HCT116 cells. Accumulation Beclin-1 microtubule-associated 1 light chain 3 II (LC3-II), the...
Diallyl trisulfide (DATS), derived from garlic, is a well-known hydrogen sulfide (H2 S) donor. H2 S has recently emerged as novel gasotransmitter involved in the regulation of cancer progression. The present study demonstrated that DATS along with other two donors, NaHS and GYY4137, significantly inhibited papillary thyroid carcinoma KTC-1 cells growth. treatment triggered rapid generation within 5 min cells. Iodoacetamide, potent thiol blocker reagent, partially rescued cell membrane damage...
Capsaicin (CAP) is a well-known anti-cancer agent. Recently, we reported capsaicin-induced apoptosis in anaplastic thyroid cancer (ATC) cells. It well accepted that the generation of stem cells (CSCs) responsible for dedifferentiation ATC, most lethal subtype with highly status. Whether CAP inhibited ATC growth through targeting CSCs needed further investigation. In present study, was found to induce autophagy TRPV1 activation and subsequent calcium influx. Meanwhile, dose-dependently...
Radioactive iodine (RAI) is commonly used to treat differentiated thyroid cancer (DTC). A major challenge the dedifferentiation of DTC with loss radioiodine uptake. Patients distant metastases have persistent or recurrent disease and develop resistance RAI therapy due tumor dedifferentiation. Hence, redifferentiation restore sensitivity considered a promising strategy overcome resistance. In present study, curcumin, natural polyphenolic compound, was found re-induce cell differentiation...
It is widely accepted that anaplastic thyroid carcinoma (ATC), a rare, extremely aggressive malignant, enriched by cancer stem cells (CSCs), which are closely related to the pathogenesis of ATC. In present study, we demonstrated diallyl trisulphide (DATS), well‐known hydrogen sulphide (H 2 S) donor, suppressed sphere formation and restored expression iodide‐metabolizing genes in human ATC cells, were associated with H S generation. Two other donors, NaHS GYY4137, could also suppress...