A5053572116- HIV/AIDS Research and Interventions
- Global Maternal and Child Health
- Adolescent Sexual and Reproductive Health
- HIV/AIDS Impact and Responses
- HIV, Drug Use, Sexual Risk
- Poverty, Education, and Child Welfare
- Global Public Health Policies and Epidemiology
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Health disparities and outcomes
- HIV-related health complications and treatments
- Child Nutrition and Water Access
- HIV Research and Treatment
- Data-Driven Disease Surveillance
- Food Security and Health in Diverse Populations
- Migration, Health and Trauma
- Tuberculosis Research and Epidemiology
- Healthcare Systems and Reforms
- Autopsy Techniques and Outcomes
- COVID-19 and Mental Health
- COVID-19 Impact on Reproduction
- Chronic Disease Management Strategies
- Health, Environment, Cognitive Aging
- Survey Sampling and Estimation Techniques
- Demographic Trends and Gender Preferences
Africa Health Research Institute
2016-2025
South African Medical Research Council
2020-2025
Human Sciences Research Council
2023
University of Cape Town
2023
University of Alabama at Birmingham
2022
University of Kinshasa
2020
University of the Witwatersrand
2018-2019
University of KwaZulu-Natal
2008-2018
Institute of Informatics of the Slovak Academy of Sciences
2018
Centre for the AIDS Programme of Research in South Africa
2018
Changing the value of data shown to be incorrect.Data fl ow: Passage recorded information through successive carriers.Inlier: Data falling within expected range.Outlier: outside range.Robust estimation: Estimation statistical parameters, using methods that are less sensitive effect outliers than more conventional methods.
The health and demography of the South African population has been undergoing substantial changes as a result rapidly progressing HIV epidemic. Researchers at University KwaZulu-Natal Medical Research Council established Africa Centre for Health Population Studies in 1997 funded by large core grant from Wellcome Trust, UK. Given urgent need high quality longitudinal data with which to monitor these changes, evaluate interventions mitigate impact, demographic surveillance system (DSS) was...
Objectives We evaluated whether implementation of lockdown orders in South Africa affected ambulatory clinic visitation rural Kwa-Zulu Natal (KZN). Design Observational cohort Setting Data were analysed from 11 primary healthcare clinics northern KZN. Participants A total 46 523 individuals made 89 476 visits during the observation period. Exposure interest conducted an interrupted time series analysis to estimate changes with a focus on transitions prelockdown level 5, 4 and 3 periods....
To estimate the prevalence of HIV and associated sociodemographic factors including mobility migration in a rural population KwaZulu-Natal, South Africa.A household-based serosurvey that has been under longitudinal demographic surveillance since 2000. All residents (women aged 15-49 years; men 15-54 years) sample non-residents ('migrants') who return periodically to their households area were identified approached for finger-prick testing.A total 8325/11 505 male 11 542/14 396 female traced....
Background Women have better patient outcomes in HIV care and treatment than men sub-Saharan Africa. We assessed—at the population level—whether to what extent mass is associated with changes sex disparities adult life expectancy, a summary metric of survival capturing mortality across full cascade care. also determined sex-specific trends distribution HIV-related deaths women prior at each stage clinical cascade. Methods Findings Data were collected on all occurring from 2001 2011 large...
BackgroundThere has been remarkable progress in the treatment of HIV throughout sub-Saharan Africa, but there are few data on prevalence and overlap other significant causes disease endemic populations. Our aim was to identify infectious non-communicable diseases such a population rural South Africa.MethodsWe did cross-sectional study eligible adolescents adults from Africa Health Research Institute demographic surveillance area uMkhanyakude district KwaZulu-Natal, Africa. The participants,...
Background: The rollout of antiretroviral therapy (ART) is one the largest public health interventions in Eastern and Southern Africa recent years. Its impact well described clinical cohort studies, but population-based evidence rare. Methods: We use data from seven demographic surveillance sites that also conduct community-based HIV testing collect information on uptake services. present crude death rates adults (aged 15–64) for period 2000–2011 by sex, status, treatment status. Parametric...
BackgroundBecause most deaths in Africa and Asia are not well documented, estimates of mortality often made using scanty data. The INDEPTH Network works to alleviate this problem by collating detailed individual data from defined Health Demographic Surveillance sites. By registering all over time carrying out verbal autopsies determine cause death across many such sites, standardised methods, the seeks generate population-based statistics that otherwise available.ObjectiveTo build a large...
The Africa Centre Demographic Information System (ACDIS) cohort in rural KwaZulu Natal, South Africa, was established 2000.In 2017, the expanded and renamed Population Intervention Platform (PIP). Public health priorities have changed over past 20 years, with widespread availability of ART a growing burden non-communicable disease (NCD).AHRI's research programme has shifted to address these new priorities, deliver evaluate interventions. In mid-2018, had approximately 140,000 individuals...
BackgroundAs the HIV epidemic in sub-Saharan Africa matures, evidence about age distribution of new infections and how this has changed over is needed to guide prevention. We aimed assess trends age-specific incidence six population-based cohort studies eastern southern Africa, reporting changes mean at infection, infections, birth cumulative incidence.MethodsWe used a Bayesian model reconstruct from repeated observations individuals' serostatus survival collected among population cohorts...
Objectives: To measure HIV incidence in a rural area of South Africa with high prevalence and to analyze risk factors for acquisition using prospective population-based cohort study. Methods: Data from two rounds (2003–2005) large survey KwaZulu-Natal were used calculate by sex 5-year age group. Multiple imputations (MI) adjust selection effects acquiring examined Weibull multiple regression. Results: During 5253 person-years at risk, 170 individuals became seropositive. The crude rate per...
Adolescent girls and young women (AGYW) bear the brunt of HIV epidemic in South Africa. 'DREAMS' aims to reduce incidence through multi-level combination prevention. We describe uptake sexual reproductive health (SRH) by AGYW KwaZulu-Natal (KZN), prior DREAMS.
Crude rates such as the crude death rate are functions of both age-specific and age composition a population. However, differences in structure between two populations or time periods can result specious corresponding making direct comparisons across inappropriate. Therefore, when comparing populations, it is desirable to eliminate minimize influence composition. This task accomplished by using standard yielding an age-standardized rate. paper proposes updated International Network for...
Objective To assess the effect of lockdown during 2020 COVID-19 pandemic on daily all-cause admissions, and by age diagnosis subgroups, odds mortality in a hospital rural KwaZulu-Natal (KZN). Design Observational cohort. Setting Referral for 17 primary care clinics uMkhanyakude District. Participants Data collected Africa Health Research Institute all admissions from 1 January to 20 October: 5848 patients contributed 6173 admissions. Exposure Five levels national South 27 March 2020, with...
Computer-aided digital chest radiograph interpretation (CAD) can facilitate high-throughput screening for tuberculosis (TB), but its use in population-based active case-finding programs has been limited. In an HIV-endemic area rural South Africa, we used a CAD algorithm (CAD4TBv5) to interpret x-rays (CXR) as part of mobile health effort. Participants with TB symptoms or CAD4TBv5 score above the triaging threshold were referred microbiological sputum assessment. During initial pilot phase,...
Objective: To investigate the effect of adult death on household dissolution and migration. Design: Demographic surveillance population in a rural area northern KwaZulu Natal, South Africa. Methods: Data households resident 1 January 2000 were used to examine mortality risk factors mobility between October 2002. Cox regression models assess migration, controlling for multiple including causes death, composition assets. Results: By 2002, 238 (2%) had dissolved 874 (8%) migrated out area; 21%...