A5085916365- Diabetes, Cardiovascular Risks, and Lipoproteins
- Global Public Health Policies and Epidemiology
- Obesity, Physical Activity, Diet
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Health disparities and outcomes
- Birth, Development, and Health
- Nutritional Studies and Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Chronic Disease Management Strategies
- Diabetes Management and Education
- Cardiovascular Health and Risk Factors
- Health Promotion and Cardiovascular Prevention
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Genetic Syndromes and Imprinting
- Child Nutrition and Water Access
- Global Health Care Issues
- Healthcare Systems and Reforms
- Cardiac Health and Mental Health
- Obesity and Health Practices
- Gout, Hyperuricemia, Uric Acid
- Alcohol Consumption and Health Effects
- Inflammasome and immune disorders
University of Amsterdam
2016-2025
National Human Genome Research Institute
2019-2025
National Institutes of Health
2019-2025
Amsterdam University Medical Centers
2018-2025
Public Health Service of Amsterdam
2017-2025
University of Maryland, Baltimore
2025
Johns Hopkins Medicine
2023
Johns Hopkins University
2023
Amsterdam UMC Location University of Amsterdam
2015-2021
Korle Bu Teaching Hospital
2021
Rising rates of obesity and type 2 diabetes (T2D) are impending major threats to the health African populations, but extent which they differ between rural urban settings in Africa upon migration Europe is unknown. We assessed burden T2D among Ghanaians living Ghana Ghanaian migrants different European countries.A multi-centre cross-sectional study was conducted adults (n = 5659) aged 25-70 years residing three cities (Amsterdam, London Berlin). Comparisons groups were made using prevalence...
Introduction Obesity and type 2 diabetes (T2D) are highly prevalent among African migrants compared with European descent populations. The underlying reasons still remain a puzzle. Gene–environmental interaction is now seen as potential plausible factor contributing to the high prevalence of obesity T2D, but has not yet been investigated. overall aim R esearch on O besity D iabetes A frican M igrants (RODAM) project understand for T2D sub-Saharan Africans in diaspora by (1) studying complex...
Background : West African immigrants in Europe are disproportionally affected by metabolic conditions compared to European host populations. Nutrition transition through urbanisation and migration may contribute this observations, but remains be characterised. Objective We aimed describe the dietary behaviour its socio-demographic factors among Ghanaian migrants their compatriots living different settings. Methods The multi-centre, cross-sectional RODAM (Research on Obesity Diabetes...
ABSTRACT The All of Us Research Program ( ) seeks to accelerate biomedical research and address the underrepresentation minorities by recruiting over one million ethnically diverse participants across United States. A key question is how self-identification with discrete, predefined race ethnicity categories compares genetic diversity at continental subcontinental levels. To contextualize in , we analyzed ∼2 common variants from 230,016 unrelated whole genomes using classical population...
Type 2 diabetes (T2D) results from a complex interplay between genetics and the environment. Several epigenome-wide association studies (EWAS) have found DNA methylation loci associated with T2D in European populations. However, data African populations are lacking. We undertook first EWAS for among sub-Saharan Africans, aiming at identifying ubiquitous novel T2D.
Epigenome-wide association studies (EWAS) have identified DNA methylation loci involved in adiposity. However, EWAS on adiposity sub-Saharan Africans are lacking despite the high burden of among African populations. We undertook an for anthropometric indices Ghanaians aiming to identify that significantly associated. The Illumina 450k array was used profile whole blood samples 547 from Research Obesity and Diabetes Migrants (RODAM) study. Differentially methylated positions (DMPs)...
Hypertension is a major burden among African migrants, but the extent of differences in prevalence, treatment, and control similar migrants nonmigrants living different contexts high-income countries rural urban Africa has not yet been assessed. We assessed hypertension prevalence its management relatively homogenous (Ghanaians) three European cities (Amsterdam, London, Berlin) Ghana.A multicenter cross-sectional study was conducted Ghanaian adults (n = 5659) aged 25-70 years. Comparisons...
Abstract Background Type 2 diabetes (T2D) has reached epidemic proportions globally, including in Africa. However, molecular studies to understand the pathophysiology of T2D remain scarce outside Europe and North America. The aims this study are use an untargeted metabolomics approach identify: (a) metabolites that differentially expressed between individuals with without (b) a metabolic signature associated population Sub-Saharan Africa (SSA). Methods A total 580 adult Nigerians from...
Background The prevalence of diabetes has been shown to be socially patterned but the direction association in low-income countries and among migrant populations Europe varied literature. This study examined between socioeconomic position (SEP) Ghanaians Ghana. Methods Data were derived from multicentre Research on Obesity Diabetes African Migrants (RODAM) Ghanaian adults aged 25–70 years residing (Amsterdam, Berlin London) urban rural Educational attainment (elementary, secondary or higher)...
Chronic kidney disease (CKD) is a major burden among sub-Saharan African (SSA) populations. However, differences in CKD prevalence between rural and urban settings Africa, upon migration to Europe are unknown. We therefore assessed the homogenous SSA population (Ghanaians) residing Ghana three European cities, whether conventional risk factors of explained observed differences. Furthermore, we varied individuals with hypertension diabetes compared without these conditions.For this analysis,...
Background Limited longitudinal data exist on chronic kidney disease (CKD) in African populations undergoing epidemiological transitions. We investigated incidence, long-term predictors and progression of CKD among Ghanaians residing Ghana Ghanaian migrants the Netherlands (Amsterdam). Methods findings analysed from 2183 participants transcontinental population-based prospective Research Obesity Diabetes Migrants cohort, followed for approximately 7 years. incidence its to end-stage (ESKD)...
SummaryBackgroundLongitudinal data on blood pressure changes in sub-Saharan African populations are limited despite a high hypertension burden. This study analysed systolic (SBP) change and incidence among people from Ghana living rural Ghana, urban The Netherlands Dutch European population Amsterdam, Netherlands.MethodsThe population-based Research Obesity Diabetes Migrants Prospective (RODAM-Pros) cohort included adults aged ≥18 years at baseline (2012–2015) follow-up (2019–2021) to...
Migration is associated with a substantial change in environmental exposures and health outcomes. We aimed to investigate the shift gut microbiota composition associations cardiometabolic outcomes RODAM-Pros cohort spanning multiple research sites across continents. determined of 1,177 Ghanaian participants rural Ghana, urban Amsterdam, Netherlands, using 16S rRNA sequencing. observed clear gradient alpha beta diversity from Ghana Amsterdam. used pairwise XGBoost machine learning...
Prevalence and determinants of type 2 diabetes among lean African migrants non-migrants: the RODAM study Background Exposure to adverse conditions earlier in life-course can predispose adulthood, irrespective body mass index (BMI).However, burden Africans is not well understood despite higher exposure early life conditions.Mirroring ongoing epidemiological transition, we assessed a homogenous group Ghanaians residing rural urban Ghana, as Europe. MethodsBaseline data from 2179 participants...
The importance of dietary diversification for type 2 diabetes (T2D) risk remains controversial. We investigated associations between- and within-food group variety with T2D, the role relationships between previously identified patterns (DPs) T2D among Ghanaian adults.In multi-center cross-sectional Research on Obesity Diabetes African Migrants (RODAM) Study (n = 3810; residence, 56%; mean age, 46.2 years; women, 63%), we constructed Food Variety Score (FVS; 0-20 points), Dietary Diversity...
Abstract Background/objectives We aimed to study the associations of dietary patterns (DPs) with type 2 diabetes (T2D) among Ghanaian adults. Subjects/methods In multi-centre, cross-sectional RODAM (Research on Obesity and Diabetes African Migrants) ( n = 4543), three overall DPs (“mixed”, “rice, pasta, meat fish,” “roots, tubers plantain”) two site-specific per site (rural Ghana, urban Ghana Europe) were identified by principal component analysis. The DPs–T2D calculated logistic regression...
Abstract Adult-onset diabetes mellitus (here: aDM) is not a uniform disease entity. In European populations, five subgroups have been identified by cluster analysis using simple clinical variables; these may elucidate aetiology and prognosis. We aimed at reproducing among Ghanaians with aDM, establishing their importance for diabetic complications in different health system contexts. used data of 541 aDM (age: 25–70 years; male sex: 44%) from the multi-center, cross-sectional Research on...