A5034171716- Epigenetics and DNA Methylation
- Health disparities and outcomes
- Global Public Health Policies and Epidemiology
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Cardiovascular Health and Risk Factors
- Chronic Disease Management Strategies
- SARS-CoV-2 and COVID-19 Research
- Migration, Health and Trauma
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Vaccine Coverage and Hesitancy
- Diabetes Management and Education
- Healthcare Systems and Reforms
- Long-Term Effects of COVID-19
- Blood Pressure and Hypertension Studies
- COVID-19 and healthcare impacts
- COVID-19 and Mental Health
- Global Health Care Issues
- Health Promotion and Cardiovascular Prevention
- Intergenerational Family Dynamics and Caregiving
- Diet, Metabolism, and Disease
- Sodium Intake and Health
University of Amsterdam
2018-2025
Amsterdam University Medical Centers
2019-2025
Public Health Service of Amsterdam
2018-2025
Stockholm University
2023
GGD Amsterdam
2023
University of Copenhagen
2023
Malawi Epidemiology and Intervention Research Unit
2017-2019
UCLouvain
2017
Comprehensive data on long COVID across ethnic and migrant groups are lacking. We investigated incidence, nature of symptoms, clinical predictors, duration among COVID-19 hospitalised patients in the Netherlands by migration background (Dutch, Turkish, Moroccan, Surinamese origin, Others).We used admissions follow up (January 2021-July 2022) from Amsterdam University Medical Centers. calculated incidence proportions per NICE guidelines assessed for predictors via robust Poisson regressions....
An abstract is not available for this content so a preview has been provided. As you have access to content, full PDF via the 'Save PDF' action button.
Europe and North America are the 2 largest recipients of international migrants from low‐resource regions in world. Here, large differences cardiovascular disease (CVD) morbidity death exist between host populations. This review discusses CVD burden its most important contributors among migrant groups as well consequences migration to high‐income countries on diagnosis therapy. The available evidence indicates that generally have a higher risk compared with Cardiometabolic, behavioral,...
Background Limited longitudinal data exist on chronic kidney disease (CKD) in African populations undergoing epidemiological transitions. We investigated incidence, long-term predictors and progression of CKD among Ghanaians residing Ghana Ghanaian migrants the Netherlands (Amsterdam). Methods findings analysed from 2183 participants transcontinental population-based prospective Research Obesity Diabetes Migrants cohort, followed for approximately 7 years. incidence its to end-stage (ESKD)...
SummaryBackgroundLongitudinal data on blood pressure changes in sub-Saharan African populations are limited despite a high hypertension burden. This study analysed systolic (SBP) change and incidence among people from Ghana living rural Ghana, urban The Netherlands Dutch European population Amsterdam, Netherlands.MethodsThe population-based Research Obesity Diabetes Migrants Prospective (RODAM-Pros) cohort included adults aged ≥18 years at baseline (2012–2015) follow-up (2019–2021) to...
Migrant populations in Europe have a type 2 diabetes (T2D) burden two to five times that of non-migrants. However, the role psychosocial stressors-whose experiences can uniquely vary across population groups-remains underexplored. We examined associations between work stress, home and adverse life events with T2D major ethnic groups The Netherlands. used baseline data from HELIUS cohort (2011-2015), including 21,501 adults Dutch, Moroccan, Turkish, South-Asian Surinamese, African Ghanaian...
Prevalence and determinants of type 2 diabetes among lean African migrants non-migrants: the RODAM study Background Exposure to adverse conditions earlier in life-course can predispose adulthood, irrespective body mass index (BMI).However, burden Africans is not well understood despite higher exposure early life conditions.Mirroring ongoing epidemiological transition, we assessed a homogenous group Ghanaians residing rural urban Ghana, as Europe. MethodsBaseline data from 2179 participants...
Background It is not known how differences in COVID-19 deaths by migration background the Netherlands evolved throughout pandemic, especially after introduction of prevention measures targeted at populations with a (in second wave). We investigated associations between and across first wave interwave period Netherlands. Methods obtained multiple registry data from Statistics spanning 1 March 2020 to 14 2021 comprising 17.4 million inhabitants. estimated incidence rate ratios for using...
Abstract Background The extent to which rural-to-urban migration affects risk for cardiometabolic diseases (CMD) in Africa is not well understood. We investigated prevalence and obesity, diabetes, hypertension precursor conditions by status. Methods In a cross-sectional survey Malawi (February 2013–March 2017), 13 903 rural, 9929 migrant 6741 urban residents (≥18 years old) participated. interviewed participants, measured blood pressure collected anthropometric data fasting samples estimate...
Objectives: We assessed the impacts of COVID-19 on multiple life domains across socio-demographic groups in Netherlands. Methods: After first wave, we distributed online questionnaires among 13,031 participants multi-ethnic HELIUS cohort. Questionnaires contained questions changes income status, healthy behaviors, mental health, and access to non-COVID-19 health care. then calculated differences adjusted proportions that reported negative by migration background, age, sex, education,...
African populations are experiencing health transitions due to rapid urbanization and international migration. However, the role of biological aging in this emerging burden cardiometabolic diseases (CMD) among migrant non-migrant Africans is unknown. We aimed examine differences epigenetic age acceleration (EAA) as measured by four clocks (Horvath, Hannum, PhenoAge GrimAge) their associations with factors Ghanaians Europe Ghanaians.Genome-wide DNA methylation (DNAm) data 712 from...
Cardiovascular diseases (CVD) remain the leading cause of death worldwide, with over 70% these deaths occurring in low- and middle-income regions such as Africa. However, most countries Africa do not have capacity to manage CVD. The Ghana Heart Initiative has been an ongoing national program since 2018, aimed at improving CVD care thus reducing rates Ghana. This study therefore assessing impact this initiative by identifying, baseline, gaps management CVDs within health system develop robust...
Abstract Sub-Saharan African (SSA) migrants in Europe experience psychosocial stressors, such as perceived discrimination (PD). The effect of a stressor on health could potentially be mediated via epigenetics. In this study we performed an epigenome-wide association (EWAS) to assess the between levels PD with genome-wide DNA methylation profiles SSA migrants. Illumina 450 K DNA-methylation array was used whole blood samples 340 Ghanaian adults residing three European cities from...
Abstract Background Although risk factors for differences in SARS-CoV-2 infections between migrant and non-migrant populations high income countries have been identified, their relative contributions to these infections, which could aid the preparation future viral pandemics, remain unknown. We investigated of pre-pandemic intra-pandemic activities differential Netherlands by migration background (Dutch, African Surinamese, South-Asian Ghanaians, Turkish, Moroccan origin). Methods utilized...
Ethnic minority groups have experienced a disproportionate burden of COVID-19, and should therefore be especially encouraged to receive SARS-CoV-2 vaccination. This study compared first-dose uptake the primary vaccination series across six ethnic in Amsterdam, Netherlands 2021.
A series of modifiable lifestyle factors, such as diet quality, physical activity, alcohol intake, and smoking, may drive the rising burden type 2 diabetes (T2DM) among sub-Saharan Africans globally. It is unclear whether epigenetic changes play a mediatory role in associations between these factors T2DM. We assessed comprehensive index, DNA methylation T2DM Ghanaian adults.
Chronic inflammation is a well-recognized contributor to hypertension pathogenesis. However, the role of targeting in treatment, particularly through modulation inflammatory markers like interleukin-6 (IL-6), remains less understood. We investigated effects antihypertensive medications with and without IL-6-lowering properties on long-term blood pressure (BP) control multi-ethnic cohort Netherlands.
We assessed epigenome-wide DNA methylation (DNAm) differences between migrant and non-migrant Ghanaians.
DNA-methylation has been associated with plasma lipid concentration in populations of diverse ethnic backgrounds, but epigenome-wide association studies (EWAS) West-Africans are lacking. The aim this study was to identify loci lipids Ghanaians.We conducted an EWAS using Illumina 450k array profiles extracted DNA from 663 Ghanaian participants. Differentially methylated positions (DMPs) were examined for total cholesterol (TC), LDL-cholesterol, HDL-cholesterol, and triglycerides...
Abstract Background African Americans have a high risk for type 2 diabetes (T2D) and insulin resistance. Studies among other population groups identified DNA methylation loci associated with resistance, but data in are lacking. Using profiles of blood samples obtained from the Illumina Infinium® HumanMethylation450 BeadChip, we performed an epigenome-wide association study to identify resistance 136 non-diabetic, unrelated American men (mean age 41.6 years) Howard University Family Study....
Abstract Background The extent to which psychosocial stress relates type 2 diabetes among sub‐Saharan Africans is not well understood. We assessed associations of stresses with status and glycaemic control Ghanaians. Methods used data from Research on Obesity Diabetes African Migrants (RODAM) study. performed logistic linear regression models assess association HbA1c respectively adjustments for age, sex, education other stresses. also moderation effects migration (migrant Ghanaians vs....
Abstract Molecular mechanisms at the intersection of inflammation and cardiovascular diseases (CVD) among Africans are still unknown. We performed an epigenome-wide association study to identify loci associated with serum C-reactive protein (marker inflammation) Ghanaians further assessed whether differentially methylated positions (DMPs) were linked CVD in previous reports, or estimated risk same population. used Illumina Infinium® HumanMethylation450 BeadChip obtain DNAm profiles blood...