A5035627081- Bacterial Genetics and Biotechnology
- DNA Repair Mechanisms
- Diabetes Management and Education
- Diabetes Management and Research
- Chronic Disease Management Strategies
- CRISPR and Genetic Engineering
- RNA and protein synthesis mechanisms
- DNA and Nucleic Acid Chemistry
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Gene Regulatory Network Analysis
- Evolution and Genetic Dynamics
- Obesity, Physical Activity, Diet
- Genetic factors in colorectal cancer
- Obesity and Health Practices
- Antibiotic Resistance in Bacteria
- Diet and metabolism studies
- Migration, Health and Trauma
- Mental Health Treatment and Access
- Health and Conflict Studies
- Primary Care and Health Outcomes
- Community Health and Development
- Mental Health and Patient Involvement
- Health disparities and outcomes
- Cancer Genomics and Diagnostics
Baylor College of Medicine
2011-2025
Diabetes Australia
2014-2024
Deakin University
2011-2024
University of Windsor
2021-2024
Renfe Operadora (Spain)
2014
Green Cross International
2014
Children's Cancer Center
2013
Monash University
2013
World Health Organization - Pakistan
2011
University of Nottingham
2003
Spontaneous DNA breaks instigate genomic changes that fuel cancer and evolution, yet direct quantification of double-strand (DSBs) has been limited. Predominant sources spontaneous DSBs remain elusive. We report synthetic technology for quantifying using fluorescent-protein fusions end-binding protein, Gam bacteriophage Mu. In Escherichia coli GamGFP forms foci at chromosomal pinpoints their subgenomic locations. occur mostly one per cell, correspond with generations, supporting replicative...
OBJECTIVE To investigate glycemic and psychosocial outcomes with hybrid closed-loop (HCL) versus user-determined insulin dosing multiple daily injections (MDI) or pump (i.e., standard therapy for most adults type 1 diabetes). RESEARCH DESIGN AND METHODS Adults diabetes using MDI without continuous glucose monitoring (CGM) were randomized to 26 weeks of HCL (Medtronic 670G) continuation current therapy. The primary outcome was masked CGM time in range (TIR; 70–180 mg/dL) during the final 3...
Bistable epigenetic switches are fundamental for cell fate determination in unicellular and multicellular organisms. Regulatory proteins associated with bistable often present low numbers subject to molecular noise. It is becoming clear that noise gene expression can influence fate. Although the origins consequences of have been studied, stochastic transient nature RNA errors during transcription has not considered origin or modeling nor capacity such information transfer generate heritable...
The lysis/lysogeny switch of bacteriophage lambda serves as a paradigm for binary cell fate decision, long-term maintenance cellular state and stimulus-triggered switching between states. In the literature, system is often referred to "bistable." However, it remains unclear whether this term provides an accurate description or instead misnomer. Here we address question directly. We first quantify transcriptional regulation governing lysogenic using single-cell fluorescence reporter. then use...
σS is an alternative sigma factor, encoded by the rpoS gene, that redirects cellular transcription to a large family of genes in response stressful environmental signals. This so-called general stress necessary for survival many bacterial species and controlled complex, multifactorial pathway regulates levels transcriptionally, translationally, posttranslationally Escherichia coli It was shown previously factor DksA its cofactor, ppGpp, are among factors governing synthesis, thus playing...
Health professionals have expressed unmet needs, including lacking the skills, confidence, training, and resources needed to properly attend psychological needs of people with diabetes.Informed by assessments, this study aimed develop practical, evidence-based support health address emotional adults type 1 or 2 diabetes.We developed a new handbook toolkit informed formative evaluation, literature reviews, stakeholder consultation review, qualitative study. In study, participated in...
To understand the day-to-day pathophysiology of impaired muscle glycogen storage in type 2 diabetes, concentrations were measured before and after consumption sequential mixed meals (breakfast: 190.5 g carbohydrate, 41.0 fat, 28.8 protein, 1,253 kcal; lunch: 203.3 48.1 44.0 1,497.5 kcal) by use natural abundance 13 C magnetic resonance spectroscopy. Subjects with diet-controlled diabetes ( n = 9) age- body mass index-matched nondiabetic controls studied. Mean fasting gastrocnemius...
Transmission of cellular identity relies on the faithful transfer information from mother to daughter cell. This process includes accurate replication DNA, but also correct propagation regulatory programs responsible for identity. Errors in DNA (mutations) and protein conformation (prions) can trigger stable phenotypic changes cause human disease, yet ability transient transcriptional errors produce heritable change ('epimutations') remains an open question. Here, we demonstrate that made...
Freeze-frame synthetic proteins trap DNA reaction intermediates in single live cells, revealing origins of genome instability.
Although obesity among immigrants remains an important area of study given the increasing migrant population in Australia and other developed countries, research on factors amenable to intervention is sparse. The aim was develop a culturally-competent prevention program for sub-Saharan African (SSA) families with children aged 12–17 years using community-partnered participatory approach. A approach that allowed be collaborative partnership communities used. Three pilot studies were carried...
Although childhood obesity prevalence is stabilised in developed countries including Australia, it continuing to rise among migrants and socially disadvantaged groups these countries. African refugees particular, are at high risk of due changes their family dynamics. The aim this study was examine the difference between children parental perception functioning, communication, type parenting styles relationship with body mass index. A cross-sectional parent-child dyad conducted 284 families...