A5050019894- DNA and Nucleic Acid Chemistry
- Bacterial Genetics and Biotechnology
- DNA Repair Mechanisms
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Probiotics and Fermented Foods
- Bacterial Infections and Vaccines
- Evolution and Genetic Dynamics
- Microbial Metabolites in Food Biotechnology
- Legionella and Acanthamoeba research
- Bacteriophages and microbial interactions
- Bacterial biofilms and quorum sensing
- Gut microbiota and health
Baylor College of Medicine
2022-2025
Robert and Janice McNair Foundation
2022-2024
Microbiota-derived metabolites have emerged as key regulators of longevity. The metabolic activity the gut microbiota, influenced by dietary components and ingested chemical compounds, profoundly impacts host fitness. While benefits prebiotics are well-known, chemically targeting microbiota to enhance fitness remains largely unexplored. Here, we report a novel approach induce pro-longevity bacterial metabolite in gut. We discovered that specific
ABSTRACT Homologous recombination is the predominant double-strand DNA break repair pathway in Escherichia coli . A recent report of non-homologous end joining involving Ku-like Gam protein bacteriophage Mu (MuGam) has sparked interest understanding functions end-binding proteins bacteria. MuGam binds to ends, but how it interferes with or transcription live bacteria remains elusive. In E. , RNA polymerase secondary channel interactors, such as Gre factors, play a role coordinating...