A5014960581- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Advanced Glycation End Products research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetic Foot Ulcer Assessment and Management
- Alcohol Consumption and Health Effects
- Pancreatic function and diabetes
- Fatty Acid Research and Health
- Pharmacology and Obesity Treatment
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular Health and Disease Prevention
- Wound Healing and Treatments
- Cardiac Imaging and Diagnostics
- Diet and metabolism studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Forensic Toxicology and Drug Analysis
- Adipose Tissue and Metabolism
- Laser Applications in Dentistry and Medicine
- Antiplatelet Therapy and Cardiovascular Diseases
- Mesenchymal stem cell research
Deutsche Diabetes Stiftung
2019-2024
Heart and Diabetes Center North Rhine-Westphalia
2013-2022
Ruhr University Bochum
2009-2022
Parallax Research (United States)
2021
Klinik Bad Oexen
2020
Institute of Medical Microbiology and Hygiene
2016
Charité - Universitätsmedizin Berlin
2016
Johannes Gutenberg University Mainz
2016
Medizinische Hochschule Hannover
2015
Imperial College London
2015
Diabetic foot ulcers are a common complication of diabetes and require specialized treatment. Cold atmospheric plasma (CAP) has been associated with benefits in wound infection healing previous smaller series case reports. Yet the effect CAP compared standard care therapy diabetic remains to be studied.To determine whether application accelerates therapy.A prospective, randomized, placebo-controlled, patient-blinded clinical trial was conducted at 2 clinics recruitment from August 17, 2016,...
Diabetes is characterized by marked postprandial endothelial dysfunction induced hyperglycemia, hypertriglyceridemia, advanced glycation end products (AGEs), and dicarbonyls (e.g., methylglyoxal [MG]). In vitro hyperglycemia-induced MG formation could be blocked benfotiamine, but in vivo effects of benfotiamine on synthesis have not been investigated humans until now.Thirteen people with type 2 diabetes were given a heat-processed test meal high AGE content (HAGE; 15.100 kU, 580 kcal, 54 g...
Despite improvements in surgical revascularisation, limitations like anatomical factors or atherosclerosis limit the success of revascularisation diabetic patients with critical limb ischaemia. Stem cells were shown to improve microcirculation published studies. The aim this study was evaluate safety, feasibility and efficacy transplantation bone marrow derived cellular products regarding improvement lowering amputation rate.Bone mononuclear (BMCs) comparison expanded enriched CD90+ ('tissue...
Objective— MicroRNAs (miRNA/miR) are stably present in body fluids and increasingly explored as disease biomarkers. Here, we investigated influence of impaired wound healing on the plasma miRNA signature their functional importance patients with type 2 diabetes mellitus. Approach Results— array profiling identified 41 miRNAs significantly deregulated diabetic controls when compared mellitus–associated peripheral arterial chronic wounds. Quantitative real-time polymerase chain reaction...
In therapy of the metabolic syndrome, optimal dietary approach with regard to its macronutrient composition and metabolically favourable food components, such as plant-derived n -3 fatty acid α-linolenic (ALA), is still a matter debate. We investigated effects hypoenergetic diet low energy density (ED) enriched in rapeseed oil, resulting high MUFA content an ALA intake 3·5 g/d on body weight cardiovascular risk profile eighty-one patients syndrome comparison olive oil rich MUFA, but content....
Objective— Diabetes mellitus involves vascular inflammatory processes and is a main contributor to cardiovascular mortality. Notably, heightened levels of circulating tissue factor (TF) account for the increased thrombogenicity put those patients at risk thromboembolic events. Here, we sought investigate role micro-RNA (miR)–driven TF expression in diabetes mellitus. Approach Results— Plasma samples with were analyzed protein activity as well miR-126 before after optimization antidiabetic...
Abstract Background Diabetes mellitus is characterized by chronic vascular inflammation leading to pathological expression of the thrombogenic full length (fl) tissue factor (TF) and its isoform alternatively-spliced (as) TF. Blood-borne TF promotes (F) Xa generation resulting in a pro-thrombotic state cardiovascular complications. MicroRNA (miR)s impact gene on post-transcriptional level contribute homeostasis. Their distinct role control diabetes-related procoagulant remains poorly...
Abstract Aims Cold atmospheric plasma (CAP) has been proven to enhance wound healing in superficial, chronically infected, diabetic foot ulcers. We aimed investigate the molecular drivers responsible for this macroscopically observed improvement healing. Methods Wound exudate was available from each change of dressing within a prospective, randomised, patient‐blinded clinical trial. Specific protein level analyses were conducted via multiplex ELISA samples representative subcohort (placebo:...
The importance of diabetes as a cause mortality and morbidity is well known. number patients increases alongside aging the population, raising prevalence obesity sedentary lifestyle. As disease that strongly associated with both micro- macrovascular complications, results in organ tissue damage. Cardiovascular (CVD) causes up to 70% all deaths people diabetes. epidemic will thus be followed by an diabetes-related vascular diseases. Almost two three who present symptomatic chronic heart have...
Plant-derived α-linolenic acid (ALA) may reduce the risk of CVD, possibly by decreasing systemic inflammation and improving endothelial function. In present study, effects a hypoenergetic diet rich in ALA (3·4 g/d) on biomarkers vascular function were investigated eighty-one overweight-to-obese patients with metabolic syndrome traits comparison low (0·9 g/d, control). After 6-month dietary intervention, there significant decreases serum concentrations C-reactive protein (CRP), TNF-α, IL-6,...
Abstract Methylglyoxal (MG), an arginine-directed glycating agent, is implicated in diabetic late complications. MG detoxified by glyoxalase 1 (GLO1) of the cytosolic system. The aim was to investigate effects accumulation GLO1-knockdown under hyperglycaemic conditions human aortic endothelial cells (HAECs) hypothesizing that accounts for deleterious on vascular function. SiRNA-mediated knockdown GLO1 performed and concentrations were determined. impact cell proteome targets glycation...
Advanced glycation endproducts (AGEs) and oxidative stress (OS) contribute to the development progression of diabetic complications. We have reported that dietary AGEs OS induce acute endothelial dysfunction in vivo, but little is known about their effects on adipokines. Twenty inpatients with type 2 diabetes mellitus (mean age: 55.9; range: 32-71 years), received a standard diet for 6 days. On days 4 6, high-AGE (HAGE) or low-AGE (LAGE) meal (15.100 vs. 2.750 kU AGE) were studied...