A5083965806- Data-Driven Disease Surveillance
- Respiratory viral infections research
- Influenza Virus Research Studies
- Immune responses and vaccinations
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Healthcare cost, quality, practices
- Ethics in Clinical Research
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Child and Adolescent Health
- Healthcare Systems and Challenges
- Syphilis Diagnosis and Treatment
- Delphi Technique in Research
- Antibiotic Use and Resistance
- Digital Mental Health Interventions
- Telemedicine and Telehealth Implementation
- Machine Learning in Healthcare
- COVID-19 Impact on Reproduction
- Patient-Provider Communication in Healthcare
- Electronic Health Records Systems
- Meta-analysis and systematic reviews
- Health Promotion and Cardiovascular Prevention
- Intramuscular injections and effects
- Viral Infections and Outbreaks Research
University of Oxford
2022-2024
Nuffield Orthopaedic Centre
2023
The Oxford-Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) is one Europe's oldest sentinel systems, working with the UK Health Security Agency (UKHSA) its predecessor bodies for 55 years. Its surveillance report now runs twice weekly, supplemented by online observatories. In addition to conducting from a nationally representative group practices, RSC also providing data syndromic surveillance.The aim this study was describe cohort profile at start...
Background Prepandemic sentinel surveillance focused on improved management of winter pressures, with influenza-like illness (ILI) being the key clinical indicator. The World Health Organization (WHO) global standards for influenza include monitoring acute respiratory infection (ARI) and ILI. WHO’s mosaic framework recommends that strategies countries virological viruses pandemic potential such as influenza. Oxford-Royal College General Practitioner Research Surveillance Centre (RSC) in...
COVID-19 vaccines have been shown to be highly effective against hospitalisation and death following infection. vaccine effectiveness estimates severe endpoints among individuals with clinical conditions that place them at increased risk of critical disease are limited.
Innovation in seasonal influenza vaccine development has resulted a wider range of formulations becoming available. Understanding coverage across populations including the timing administration is important when evaluating benefits and risks.
Globally, there are marked inconsistencies in how immunosuppression is characterized and subdivided into clinical risk groups. This detrimental to the precision comparability of disease surveillance efforts-which has negative implications for care those who immunosuppressed their health outcomes. was particularly apparent during COVID-19 pandemic; despite collective motivation protect these patients, conflicting definitions created international rifts were monitored managed this period. We...
Molecular point-of-care testing (POCT) used in primary care can inform whether a patient presenting with an acute respiratory infection has influenza. A confirmed clinical diagnosis, particularly early the disease, could better antimicrobial stewardship. Social distancing and lockdowns during COVID-19 pandemic have disturbed previous patterns of influenza infections 2021. However, data from samples taken last quarter 2022 suggest that represents 36% sentinel network positive virology,...
While the COVID-19 pandemic provided a global stimulus for digital health capacity, its development has often been inequitable, short-term in planning, and lacking system coherence. Inclusive of resilient systems are broad outcomes that require systematic approach to achieving them. This paper from IMIA Primary Care Informatics Working Group (WG) provides necessary first steps design primary care can support equity resilience.We report on capability growth maturity four key areas: (1)...
<sec> <title>BACKGROUND</title> The Oxford-Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) is one Europe’s oldest sentinel systems, working with the UK Health Security Agency (UKHSA) its predecessor bodies for 55 years. Its surveillance report now runs twice weekly, supplemented by online observatories. In addition to conducting from a nationally representative group practices, RSC also providing data syndromic surveillance. </sec>...
<sec> <title>BACKGROUND</title> Globally, there are marked inconsistencies in how immunosuppression is characterized and subdivided into clinical risk groups. This detrimental to the precision comparability of disease surveillance efforts—which has negative implications for care those who immunosuppressed their health outcomes. was particularly apparent during COVID-19 pandemic; despite collective motivation protect these patients, conflicting definitions created international rifts were...
The sensitivity of human tissue and previous instances misuse have, rightfully, led to the introduction far-reaching oversight regulatory mechanisms for accessing, storing sharing samples. However, these restrictions, in tandem with more broad-based privacy regulations, have had unintended consequence obstructing legitimate requests medical materials. This is real detriment ambitions biomedical research, most notably precision medicine agenda. As such, this paper makes case facilitating...
IntroductionRespiratory sentinel surveillance systems leveraging computerised medical records (CMR) use phenotyping algorithms to identify cases of interest, such as acute respiratory infection (ARI). The Oxford-Royal College General Practitioners Research and Surveillance Centre (RSC) is the English primary care-based network.AimThis study describes validates RSC's new ARI algorithm.MethodsWe developed algorithm using a framework aligned with international interoperability standards. We...
<sec> <title>BACKGROUND</title> Patients with immune-mediated inflammatory disease (IMID), including autoimmunity, fared significantly worse than the general population during COVID-19 pandemic both in terms of infection outcomes and levels life disruption. Despite this, vaccine uptake has not been universal. The absence IMID patients from clinical trials subsequent lack precision safety profiling adds to hesitancy this high-risk group. </sec> <title>OBJECTIVE</title> present protocol sets...
Adults classified as immunosuppressed have been disproportionately affected by the COVID-19 pandemic. Compared to immunocompetent, certain patients are at increased risk of suboptimal vaccine response and adverse health outcomes if infected. However, there has insufficient work pinpoint where these risks concentrate within spectrum; surveillance efforts typically treat a single entity, leading wide confidence intervals. A clinically meaningful computerised medical record (CMR) compatible...
<sec> <title>BACKGROUND</title> Prepandemic sentinel surveillance focused on improved management of winter pressures, with influenza-like illness (ILI) being the key clinical indicator. The World Health Organization (WHO) global standards for influenza include monitoring acute respiratory infection (ARI) and ILI. WHO’s mosaic framework recommends that strategies countries virological viruses pandemic potential such as influenza. Oxford-Royal College General Practitioner Research Surveillance...
This short communication makes the case for targeted vaccine research when attempting to counter hesitancy, especially amongst vulnerable or rarefied patient groups. Far from disincentivizing vaccination, freedom and publicize limitations of these technologies certain groups personalizing dosing, pacing, adjuvants, time-sensitive alternatives in response is essential optimizing health outcomes while neutralizing landscape itself. Vaccine evangelism only arouses suspicion it not tempered by...
<sec> <title>BACKGROUND</title> Innovation in seasonal influenza vaccine development has resulted a wider range of formulations becoming available. Understanding coverage across populations including the timing administration is important when evaluating benefits and risks. </sec> <title>OBJECTIVE</title> This study aims to report representativeness, uptake vaccines, different within English Primary Care Sentinel Cohort (PCSC). <title>METHODS</title> We used PCSC Oxford-Royal College General...
<sec> <title>BACKGROUND</title> Molecular point-of-care testing (POCT) used in primary care can inform whether a patient presenting with an acute respiratory infection has influenza. A confirmed clinical diagnosis, particularly early the disease, could better antimicrobial stewardship. Social distancing and lockdowns during COVID-19 pandemic have disturbed previous patterns of influenza infections 2021. However, data from samples taken last quarter 2022 suggest that represents 36% sentinel...
Mounting evidence for poorer seroconversion and accelerating vaccine waning in clinical risk groups (CRGs) suggests that, even if vaccinated, monoclonals antivirals may still be required. However, the efficacy of said alternatives are highly time sensitive. As such, a workflow that unlocks access to these treatments both timely antimicrobially-responsible manner is essential. In-practice point-of-care testing (POCT) offer solution this dual challenge.The present study investigated uptake...