Sex-dependent differences in stress-induced depression in Wistar rats are accompanied predominantly by changes in phosphatidylcholines and sphingomyelins.

• DOI: 10.26402/jpp.2021.4.14
• Publication Date: 2021-08-01
• Authors: E Leskanicova; Marián Babinčák; F Mochnacky; Natália Kokošová; Diana Kúkeľová; Nicol Urbanská; Mariana Kolesárová; Denisa Maceková; Jozef Kostolný; Terézia Kisková
• Keywords: Depression; History of depression

With a high annual and lifetime prevalence, depression is becoming the leading contributor to global disease burden. During COVID-19 crisis, mood disorders accelerated significantly. Despite growing evidence, precise underlying mechanisms of (DD) remain unknown. When studying DD in humans, there are many uncontrollable factors such as medication history, age patient or living conditions. In this regard, animal models provide an essential step for examining neural circuitry molecular cellular pathways controlled environment. As far we know, women have consistently higher prevalence than men. Thus, aim our study was evaluate sex-related changes blood metabolites model stress-induced Wistar rats. Pregnant females were stressed using restriction mobility final week pregnancy three times day 45 minutes each, following days. After birth, progeny aged 60 days repeatedly. The perturbation overall energy metabolism well lipid found. While males, phosphatidylcholines (the most phosphatidylcholine with acyl-alkyl residue sum C40:4 - PC ae C40:4), sphingomyelins, acylcarnitines changed, females, seen critical alteration hydroxysphingomyelin acyl C16:1 (SM OH C16:1). Our results confirm that may be used further research depression. insight into sex-dependent pathogenesis contribute search effective treatment prevention respect sex.