Placental transfer and neonatal effects of dexmedetomidine during cesarean section under general anesthesia

• DOI: 10.3760/cma.j.issn.0254-1416.2016.04.028
• Publication Date: 2016-04-20
• Authors: Chuanbao Han; Xiuhong Jiang; Yu Li; Xia Wu; Zhengnian Ding
• Keywords: Dexmedetomidine; Umbilical artery; Apgar score; Arterial blood

Objective To investigate the placental transfer and neonatal effects of dexmedetomidine during cesarean section under general anesthesia.

Methods Thirty-eight nulliparous parturients, American Society Anesthesiologists physical statusⅠ or Ⅱ, aged 22-37 yr, weighing 56-82 kg, who were at full term with a singleton fetus, scheduled for elective caesarean anesthesia, randomly divided into 2 groups (n=19 each) using random number table: group (group D) normal saline N). In D, was infused in loading dose 0.6 μg/kg starting from 10 min before induction followed by an infusion 0.4 μg·kg-1·h-1 until peritoneal closure.Group N received equal volume saline.Blood samples collected maternal artery (MA), umbilical vein (UV), (UA) blood gas analysis determination plasma concentrations (CMA, CUV CUA) high-performance liquid chromatography-mass spectrometry, CUV/CMA CUA/CUV calculated.Apgar scores recorded 1 5 after delivery, occurrence respiratory depression also recorded.The I-D interval (the time administration anesthetics to delivery) U-D incision uterus recorded.

Results There no significant differences parameters MA, UV UA, interval, Apgar between two (P>0.05). No found both groups.In CMA, CUA 471±119, 359±88 (321±78) ng/ml, respectively, 0.76±0.06, 0.89±0.03.

Conclusion Although metabolism is little easy transfer, has adverse on newborn anesthesia.

Key words: Dexmedetomidine; Cesarean section; Infant, newborn; Placenta