Comparison of dexmedetomidine administered via different routes for epidural anesthesia during second cesarean section

• DOI: 10.3760/cma.j.issn.0254-1416.2017.04.028
• Publication Date: 2017-04-20
• Authors: Xia Wu; Chuanbao Han; Xiuhong Jiang; Zhiping Ge
• Keywords: Ropivacaine; Dexmedetomidine; Epidural administration; Epidural space

Objective To compare dexmedetomidine administered via different routes for epidural anesthesia during second cesarean section.

Methods Sixty parturients who were at full term with a singleton fetus, of American Society Anesthesiologists physical statusⅠor Ⅱ, aged 22-38 yr, weighing 58-84 kg, undergoing caesarean section under anesthesia, divided into 3 groups(n=20 each)using random number table: IV infusion combined injection ropivacaine group(VDER group), mixture and group(ERD group)and group(ER group). The puncture was performed L2, 3.After identification the space negative aspiration test blood or cerebrospinal fluid, 0.75% 15 ml 0.9% normal saline 2 injected epidurally, 1 μg/kg intravenously infused 10 min same time in VDER group; epidurally ERD ER group.The onset block, maximum level to reach block sensory recorded.Ramsay sedation scores assessed 30 after end administration, intraoperative traction reaction also assessed.The development hypotension, bradycardia, respiratory depression shivering observed.The patients whom remifentanil used before delivery Apgar 5 birth recorded.

Results Compared group group, significantly shortened, prolonged group(P 0.05).

Conclusion Both can enhance efficacy section, producing no adverse effects on neonates; provides faster which is helpful postoperative analgesia.

Key words: Dexmedetomidine; Anesthesia, epidural; Cesarean section; Scar uterus