Clinical analysis of early allograft dysfunction in patients receiving donation after cardiac death liver Transplantation

• DOI: 10.3760/cma.j.issn.0254-1785.2016.09.002
• Publication Date: 2016-09-20
• Authors: Fei Sun; Lei Geng; Mangli Zhang; Sheng Yan; Weilin Wang

Objective To investigate the occurrence and influencing factors of early allograft dysfunction (EAD) in patients receiving donation after cardiac death (DCD) liver Transplantation.

Methods Forty-five received orthotopic transplantation our center during January 2016 May were included this study. Based on EAD, divided into EAD group non-EAD group. Perioperative data donors recipients collected to analyze risk effect short-term prognosis patients.

Results In 45 patients, incidence was 57.8% (26 cases). During follow-up period, mortality 15.4% 15.8% respectively, which showed no significant difference. Donor age, preoperative ALT AST levels, cold ischemia time (CIT) significantly increased than (43.7±2.5 36.2±2.5, P=0.040 9; 64.2±13.2 31.0±5.9, 7; 87.3±16.2 48.2±6.2, P=0.047 3; 629.5±35.2 484.6±30.5, P=0.004 0, respectively). CRP level higher (22.6±5.9 4.7±1.1, P=0.012 1). What's more, postoperative platelet lower (73.7±8.0 111.7±16.0, P=0.043 9). However, pre- post-operative neutrophil-lymphocyte ratio (NLR) difference between groups.

Conclusion Older donor high levels AST, prolonged ischemic time, as well decrease are for transplantation.

Key words: Liver transplantation; Organ donation; Hepatic insufficiency