The clinical pathologic research of the pathological morphologic characteristics of invasive pituitary adenomas and its expression of Ki-67 and MMP-9

• DOI: 10.3760/cma.j.issn.1001-2346.2013.05.010
• Publication Date: 2013-05-28
• Authors: Lingchuan Guo; Yushuang Zheng; Weishuo Liu; Suya Kang
• Keywords: Ki-67; Atypia; Pleomorphism (cytology); Nuclear atypia

Objective To study the pathological morphologic characteristics of invasive pituitary tumors and affect expression Ki-67 MMP-9 to tumor invasion.Methods Analyzing 130 cases specimens from January 2003 december 2011,which divided into two groups according invasion,observe through light electron microscope via immunohistochemistry (IHC).Results The difference was statistically significant(P ＜ 0.05) between group noninvasive in incidence rate characteristics,such as high nuclearcytoplasmic ratio,cell pleomorphism,nuclear atypia,and nucleoli appearence; nuclear atypia nucleolus margination were found microscopy.therein addition,significant statistical differences expressions ; higher than group(P 0.01).Conclusions significantly valuable diagnosis aggressiveness,which provided indicators for early clinical invasion.

Key words: Pituitary adenoma; Invasion; Pathological morphology; ;