Effects of pulsed radiofrequency with different exposure times on pain threshold in the rat CCI model

• DOI: 10.3760/cma.j.issn.1672-9633.2017.06.005
• Publication Date: 2017-12-25
• Authors: Xiaodong Wang; Zhaoxia Xue; Baozhong Yang; Baoliang Geng
• Keywords: Pulsed radiofrequency; Rat model; Animal model

Objective To observe the effects of different exposure times under pulsed radiofrequency (PRF) on thermal withdrawal latency (TWL) and mechanical threshold (MWT) in rat model with chronic constriction injury (CCI).

Methods Seventy-two adult male SD rats were randomly divided into 4 groups: sham group, PRF-120 s PRF-480 group PRF-720 18 each group. The only placed RF needle without pulse intervention, while other groups treated PRF intervention (2 Hz, 55 V) after CCI was successfully established interventional time 120 s, 480 720 respectively. TWL MWT determined before model, establishment (7 d model) 1, 4, 7, 10, 14, 17, 21 PRF.

Results No differences found among all (P>0.05). After model), significantly lower than those (P<0.05). At 17 PRF, higher (P<0.01). 21d (P<0.05).

Conclusion PRF treatment can raise pain rat's is a definite analgesic effect neuropathic pain. Increased from to shows significant enhancement effect.

Key words: Pulsed radiofrequency; Exposure time; Neuropathic pain; Pain threshold; Models, animal