Changes of plasma atrial natriuretic polypeptide and angiotensin II during laparoscopic operation with different posture

• DOI: 10.3760/cma.j.issn.1674-4756.2012.02.004
• Publication Date: 2012-01-25
• Authors: Demin Tian; Xiaodong Wang; Cheng-xiao Zhou
• Keywords: Supine position; Head-Down Tilt; Venous blood; Plasma levels; Atrial natriuretic peptide

Objective To observe the effects of different posture on plasma ANP and AngⅡ during laparoscopy.Methods Forty patients,ASA class I or Ⅱ,scheduled for elective laparoscopy surgery under general anesthesia were included in this study.The patients randomly divided into two groups according to their laparoscopy(20 cases each group).The group A arranged a head-down tilt position B head-up requirement operation.Blood samples taken from central venous at four time points before pneumoperitoneum(T1),after 10 minutes(T2)and 20 mintues(T3)when operation-needed with stable pneumoperitoneum pressure 14 mm Hg(1 mm.Hg =0.133 kPa),and 5 minutes(T4)after deflation when returned supine position.The Ang Ⅱ assessed by radioimmunoassay.Resuits The level was higher T2 than that T1,and it significantly T3 T1 (P ＜ 0.05).ANP same 0.05).Ang levels both 0.01),but there no significant difference between ＞ 0.05).Conclusions may have obvious effect pneumoperitoneum.It Ⅱ.

Key words: General anesthesia; Artificial pneumoperitoneum; Posture; Atrial natriuretic polypeptide; Angiotensin