Hemodynamic and growth effect of indomethacin on fetal goat model of intrauterine balloon aortic valvuloplasty

• DOI: 10.3760/cma.j.issn.2095-428x.2014.02.004
• Publication Date: 2014-01-20
• Authors: Kaiyu Zhou; Liang Zhao; Yifei Li; Chuan Wang; Gang Wu; Nan Guo; Hongyu Duan; Qi Zhu
• Keywords: Aortic valvuloplasty; Ductus arteriosus

Objective To investigate the fetal hemodynamic and growth effect, maternal pregnant outcome of indomethacin on goat model intrauterine balloon aortic valvuloplasty(IUBAV).

Methods Forty twin goats(106-124 gestational days, term: 150 days) were designed as research objects IUBAV was established.According to whether adopting goat, 40 goats randomly divided into control group(placebo n=20) group(feeding n=20). According administration, 80 sheep then enrolled 4 groups.A1 group: placebo+ control, A2 IUBAV, B1 indomethacin+ B2 IUBAV.Following parameters included statistical analysis done among diffe-rent groups, which heart rate, biparietal diameter, annulus umbilical/aortic systolic peak velocity end diastolic ratio(S/D), diameter ductus arteriosus flow pattern trans blood flow, body weight hematocrit full-term newborn goats.

Results After adopting, post-procedure preterm birth rate decreased from 50.00% 8.33%.Fetal S/D increased post-procedure, gradually recovered 3-day there existed significant differences groups(P 0.05) after administration.After no difference all groups in annular goats(P>0.05).

Conclusions Indomethacin can improve post-IUBAV pregnancy ewes, provide protective inhibition effects changes goats, could avoid constriction, retardation, is proved be an effective measure cardiac intervention.

Key words: Fetal goat; Intrauterine; Balloon valvuloplasty; Indomethacin; Hemodynamics