Bi-directional signaling pathway of erythropoietin-producing hepatocyte receptors between osteoblasts and osteoclasts

• DOI: 10.3877/cma.j.issn.1674-134x.2018.03.018
• Publication Date: 2018-06-01
• Authors: Yu‐Wei Ge; Zhen-an Zhu
• Keywords: Ephrin

The balance of bone remodeling is regulated by direct contact between osteoblasts and osteoclasts, which also determines the indivisibility two. Recent studies have shown that erythropoietin producing hepatomocellular receptor interacting protein (Ephrin) ligand B2 in pre-osteoclasts erythropoietin-producing hepatocyte(Eph)receptor B4 on membrane regulate homeostasis through contact, thereby activating downstream signaling pathways. Forward signaling: activation molecules Ras homolog gene family member A (Rho A) activity Eph receptors surface osteoblast membranes promotes differentiation maturation pre-osteoclasts. Reverse EphrinB2 ligands plays a reverse role inhibiting osteoclast C-fos/NFATc1 transcriptional cascade osteoclast-related transcription factors. Osteolysis caused wear particles can significantly increase expression ephrinB2 promote high NFATc1. However, bidirectional pathway be used to reduce or even inhibit further osteoclasts particles.

Key words: Osteoblasts; Osteoclasts; Signal transduction