A5032181313- Bone Tissue Engineering Materials
- Bone Metabolism and Diseases
- Bone health and treatments
- Graphene and Nanomaterials Applications
- Calcium Carbonate Crystallization and Inhibition
- Biomarkers in Disease Mechanisms
- Orthopaedic implants and arthroplasty
- Axon Guidance and Neuronal Signaling
- Nanoplatforms for cancer theranostics
- Cancer-related gene regulation
- Adipose Tissue and Metabolism
- Curcumin's Biomedical Applications
- Medicinal Plant Pharmacodynamics Research
- Pressure Ulcer Prevention and Management
- Colorectal and Anal Carcinomas
- Alkaline Phosphatase Research Studies
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Energy Load and Power Forecasting
- Colorectal Cancer Surgical Treatments
- Advanced Thermodynamic Systems and Engines
- Bone and Dental Protein Studies
- Bone and Joint Diseases
- Bone fractures and treatments
Nanjing University of Chinese Medicine
2025
Shanghai Sixth People's Hospital
2021-2023
Shanghai Jiao Tong University
2018-2023
Shanghai Ninth People's Hospital
2018-2021
University School
2020
ORCID
2020
Shanghai Normal University
2020
Shanghai First People's Hospital
2018
Oxidative stress plays a crucial role in the occurrence and development of osteoarthritis (OA) through activation endoplasmic reticulum (ER) stress. Curcumin is polyphenolic compound with significant antioxidant anti-inflammatory activity among various diseases. To elucidate curcumin oxidative stress-induced chondrocyte apoptosis, this study investigated effect on ER stress-related apoptosis its potential mechanism rat chondrocytes. The results flow cytometry terminal deoxynucleotidyl...
Abstract Background Breast cancer bone metastasis has become one of the most common complications; however, it may cause recurrence and nonunion, as well local defects. Methods Herein, In vitro, we verified effect bioscaffold materials on cell proliferation apoptosis through a CCK8 trial, staining live/dead cells, flow cytometry. We used immunofluorescence technology cytometry to verify whether regulate macrophage polarization, ALP staining, alizarin red PCR material promotes regeneration....
Autogenous bone grafting has long been considered the gold standard for treating critical defects. However, its use is plagued by numerous drawbacks, such as limited supply, donor site morbidity, and restricted giant-sized For this reason, there an increasing need effective substitutes to treat these Mollusk nacre a natural structure with outstanding mechanical property due notable "brick-and-mortar" architecture. Inspired architecture, our team designed fabricated nacre-mimetic cerium-doped...
The incidence of thyroid cancer (TC) increases year by year. It is necessary to construct a prognostic model for risk stratification and management TC patients. Glutamine metabolism essential tumor progression the microenvironment. present study aimed develop predictive using glutamine gene set. Differentially expressed genes in cells with high levels from single cell RNA‑sequencing data were compared differentially between normal tissues Cancer Genome Atlas Program data. Through Boruta...
Surgical site infection (SSI) continues to be one of the most common postoperative complications. In our previous study, surgical mask (SM) bioburden was identified a potential source SSI. present we investigated factors involved in SM bioburden.Bioburdens disposable (A: medical mask; B: mask) and newly laundered cloth (C) were tested by immediately making an impression external surface on sterile culture media. microstructure observed using scanning electron microscope (SEM). Filtering...
The repair of large bone defects has always been a challenge, especially with respect to regeneration capacity and autogenous availability. To address this problem, we fabricated 3D-printed polylactic acid (PLA) hydroxyapatite (HA) scaffold (3D-printed PLA-HA, providing scaffold) loaded enhanced marrow (eBM, seed cells) combined induced membrane (IM, grow factors) radial in rabbits. vitro assays, demonstrated that PLA-HA had excellent biocompatibility, as shown by co-culturing mesenchymal...
Calcium phosphate silicate (Ca5(PO4)2SiO4 or CPS) is a promising bioceramic for bone grafting. Iron (Fe) trace element in the human body that has been reported to enhance mechanical strength of CPS ceramics. However, exact biofunctions Fe, combined with another element, viz. silicon (Si), and optimal dose Fe addition must be further investigated. In vitro: morphology, structure cell adhesion were observed by SEM; ability promote osteogenic differentiation mineralization was explored ALP...
An amendment to this paper has been published and can be accessed via the original article.
Purpose: Mesoporous hydroxylapatite (MHAP) might be important for bone regeneration, and ursolic acid (UA) has anti-inflammatory effects. Accordingly, we developed, the first time, acid-loaded MHAP-chitosan (MHAP-CS-UA) scaffolds to treat defects. Methods: In vitro, synthesize biomaterial scaffolds. By SEM, XRD, EDS FTIR, test performance of hybrid drug release, flow cytometry, immunofluorescence, alizarin red staining, Western blotting, osteo-inductive properties vivo, verify...
Abstract This work describes the design, construction and testing of a 1.5 T cryogen-free low-temperature superconductor niobium–titanium whole-body magnet with bore diameter 850 mm that is suitable for clinical magnetic resonance imaging (MRI) applications. The actively shielded passively shimmed to achieve confinement within 0.5 mT stray field at 2.5/4 m radial/axial positions 12.1 ppm inhomogeneity over 45 spherical volume. conductively refrigerated using two-stage Gifford–McMahon...
Aseptic loosening caused by wear particles is one of the common complications after total hip arthroplasty. We investigated effect recombinant protein ephB4-Fc (erythropoietin-producing human hepatocellular receptor 4) on particle-mediated inflammatory response. In vitro, ephrinB2 expression was analyzed using siRNA-NFATc1 (nuclear factor activated T-cells 1) and siRNA-c-Fos. Additionally, we used Tartrate-resistant acid phosphatase (TRAP) staining, bone pit resorption, Enzyme-linked...
The present study investigated the role of bidirectional ephrin‑B2/erythropoietin‑producing human hepatocellular receptor 4 (ephB4) signaling in regulation wear particle‑mediated osteoclastogenesis vitro. Mouse bone marrow macrophages (BMMs) were induced into osteoclasts by activator nuclear factor‑κB ligand (RANKL, 50 ng/ml). EphB4‑Fc, an osteoblast membrane surface (4 µg/ml), was used to stimulate ephrin‑B2 presence and absence titanium (Ti). Tartrate‑resistant acid phosphatase (TRAP)...
Abstract Background: Breast cancer bone metastasis has become one of the most common complications; however, it may cause recurrence and nonunion, as well local defects. Methods: Herein, In vitro, we verified effect bioscaffold materials on cell proliferation apoptosis through a CCK8 trial, staining live/dead cells, flow cytometry. We used immunofluorescence technology cytometry to verify whether regulate macrophage polarization, ALP staining, alizarin red PCR material promotes regeneration....
Abstract Background Breast cancer bone metastasis has become one of the most common complications; however, it may cause recurrence and nonunion local defects. Methods Herein, In vitro, we verified effect bioscaffold materials on cell proliferation apoptosis through CCK8 experiment, staining living dead cells, flow cytometry. We used immunofluorescence technology cytometry to whether regulated polarization macrophages, use ALP staining, alizarin red PCR verify material promotes regeneration....
The balance of bone remodeling is regulated by direct contact between osteoblasts and osteoclasts, which also determines the indivisibility two. Recent studies have shown that erythropoietin producing hepatomocellular receptor interacting protein (Ephrin) ligand B2 in pre-osteoclasts erythropoietin-producing hepatocyte(Eph)receptor B4 on membrane regulate homeostasis through contact, thereby activating downstream signaling pathways. Forward signaling: activation molecules Ras homolog gene...
Background: Aseptic loosening caused by wear particles is a common complications after total hip arthroplasty. We investigated the effect of recombinant protein ephB4-Fc (erythropoietin-producing human hepatocellular receptor 4) on particle-mediated inflammatory response.Methods: In vitro, ephrinB2 expression was analyzed using siRNA-NFATc1 (nuclear factor activated T-cells 1) and siRNA-c-Fos. Additionally, we used Tartrate-resistant acid phosphatase (TRAP) staining, bone pit resorption,...