medsim a novel semantic similarity measure in bio medical knowledge graphs

• DOI: 10.48550/arxiv.1812.01884
• Publication Date: 2018-01-01
• Authors: Kai Lei; Kaiqi Yuan; Qiang Zhang; Ying Shen
• Keywords: FOS: Computer and information sciences; Computer Science - Computation and Language; 0202 electrical engineering, electronic engineering, information engineering; 02 engineering and technology; Computation and Language (cs.CL); Information Retrieval (cs.IR); Computer Science - Information Retrieval; 3. Good health

We present MedSim, a novel semantic SIMilarity method based on public well-established bio-MEDical knowledge graphs (KGs) and large-scale corpus, to study the therapeutic substitution of antibiotics. Besides hierarchy and corpus of KGs, MedSim further interprets medicine characteristics by constructing multi-dimensional medicine-specific feature vectors. Dataset of 528 antibiotic pairs scored by doctors is applied for evaluation and MedSim has produced statistically significant improvement over other semantic similarity methods. Furthermore, some promising applications of MedSim in drug substitution and drug abuse prevention are presented in case study.