Synthesis of 4'α-C Phenyl-Branched Carbocyclic Nucleoside Using Ring-Closing Metathesis

• DOI: 10.5012/bkcs.2003.24.9.1289
• Publication Date: 2010-07-08T02:51:22Z
• Authors: Joon Ho Hong; Ok Hyun Ko
• Keywords: Ring-Closing Metathesis; Acetophenone

An efficient synthetic route for preparing novel <TEX>$4'{\alpha}$</TEX>-C phenyl branched carbocyclic nucleoside is described. The installation of group at the <TEX>$4'$</TEX>-position was successfully accomplished via a sequential [3,3]-sigmatropic rearrangement and ring-closing metathesis (RCM) beginning from simple ketone such as 2-hydroxy acetophenone.