A5103203209- Organ Transplantation Techniques and Outcomes
- HIV/AIDS drug development and treatment
- Renal Transplantation Outcomes and Treatments
- Natural product bioactivities and synthesis
- Chemical Synthesis and Analysis
- Phytochemistry and Biological Activities
- Carbohydrate Chemistry and Synthesis
- Heavy Metals in Plants
- Plant-derived Lignans Synthesis and Bioactivity
- Synthetic Organic Chemistry Methods
- Analytical Chemistry and Chromatography
- Advanced Chemical Sensor Technologies
- Click Chemistry and Applications
- Seaweed-derived Bioactive Compounds
- Ginseng Biological Effects and Applications
- Heavy metals in environment
- Echinoderm biology and ecology
- Essential Oils and Antimicrobial Activity
- Organ Donation and Transplantation
- Food Quality and Safety Studies
- Plant biochemistry and biosynthesis
- Transplantation: Methods and Outcomes
- Biochemical and Molecular Research
- Veterinary medicine and infectious diseases
- Natural Compound Pharmacology Studies
Jeonnam Bioindustry Foundation
2018-2022
Jangsung (South Korea)
2019-2022
Chosun University
2003-2018
Chonnam National University
2004
Citrus fruits are known to have characteristic enantiomeric key compounds biosynthesised by highly stereoselective enzymatic mechanisms. In the past, evaluation of ratios chiral in has been applied as an effective indicator adulteration addition synthetic or natural components different botanical origin.To analyse volatile flavour junos Sieb. ex Tanaka (yuzu), limon BURM. f. (lemon) and aurantifolia Christm. Swingle (lime), determine their for discrimination authentication extracted...
Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation and inflammation. Interleukin-1β the key player in pathogenesis of OA, which induces expression various catabolic factors that contribute to degradation. Cynaroside (luteolin-7-O-glucoside or luteoloside) flavonoid has pharmacological properties, such as antitumor, anti-inflammatory, antioxidant activities. In this study, we investigated chondroprotective effects cynaroside on IL-1β-stimulated...
Osteoarthritis (OA) is characterized by cartilage degradation, inflammation, and pain. The dicaffeoylquinic acid (diCQA) isomer, 4,5-diCQA, exhibits antioxidant activity various other health-promoting benefits, but its chondroprotective effects have yet to be elucidated. In this study, we aimed investigate the of 4,5-diCQA on OA both in vitro vivo. Primary rat chondrocytes were pre-treated with for 1 h before stimulation interleukin (IL)-1β (5 ng/mL). accumulation nitrite, PGE2, aggrecan was...
Sargassum horneri (SH) is a seaweed that has several features benefit health. In this study, we investigated the immune-enhancing effect of SH, focusing on role spleen-mediated immune functions. Chromatographic analysis SH identified six types monosaccharide contents, including mannose, rhamnose glucose, galactose xylose and fucose. increased cell proliferation primary cultured naïve splenocytes treated with or without cyclophosphamide (CPA), an immunosuppression agent. also reversed...
This study aimed at analysing concentrations of heavy metals including arsenic, lead, cadmium, aluminium and mercury in commonly consumed seafood species belonging to Echinodermata (Anthocidaris crassispina Stichopus japonicus) Chordata (Halocynthia roretzi Styela plicata). The samples were digested by a microwave system analysed for As, Cd Pb inductively coupled plasma mass spectrometer, Al plasma-optical emission spectrometer Hg Direct Mercury Analyser. analytical method was validated...
Toxic hepatitis has been reported as a major cause of acute hepatitis, but its potential induction by herbal remedies and/or health foods is usually neglected.We experienced case toxic associated with Polygoni multiflori, Chinese herb commonly known Ho-Shou-Wu.A 54-year-old woman consumed Ho-Shou-Wu for 1 month, after which she fatigue and overall weakness.A diagnosis was made based on her clinical history, the findings viral markers other laboratory data, ultrasonography.Her condition...
Species of genus Garcinia are rich sources bioactive constituents with antimicrobial, anticancer, anti-inflammatory, hepatoprotective and anti-HIV activities. Commercial products cambogia used as anti-obesity drugs increasing market demand. Because the high price its products, it can be adulterated similar lower-priced species. This study was designed to develop validate an accurate efficient method for detection any adulteration (G. indica) in G. products. For this purpose, performance...
Abstract This study was designed to analyze the volatile organic compounds in leaves of Ambrosia artemisiifolia L. and Artemisia annua from Korea. For extraction compounds, headspace-solid phase micro (HS-SPME) simultaneous distillation (SDE) were applied analyzed by gas chromatography/mass spectrometry (GC/MS). From results, SDE found give highest concentration with an average 1,237.79 mg/kg for A. compared 1,122.73 HS-SPME technique. A total 116 identified, including 76 similar detected...
Anthriscus sylvestris (L.) Hoffm. is a common perennial herb that widely distributed in Europe, Korea, and New Zealand. The root of A. has been used Korean traditional medicine as an antitussive cough remedy. However, the physiologically active function leaves not yet known. In this study, we evaluated anti-inflammatory effects, well underlying molecular mechanisms aqueous extract (AE-ASL) vitro vivo. Our results indicated pretreatment with AE-ASL significantly inhibited lipopolysaccharide...
The commercial products of Panax ginseng have increasing market demand and high prices due to the pharmacological activities. To obtain profits, P. may be adulterated with lower priced morphologically similar species such as Platycodon grandiflorum, Codonopsis lanceolata, Pueraria lobata. This study was designed validate accurate methods for analysis adulteration in products. High-performance liquid chromatography (HPLC) ultraperformance chromatography–diode array detector–electrospray...
A very short and concise synthetic route for a novel acyclic version of d4T is described. The required quaternary carbon was successfully installed using [3,3]-sigmatropic rearrangement. condensation the mesylates 16-18 with an adenine base under standard nucleophilic substitution conditions (<TEX>$K_2CO_3$</TEX>, 18-Crown- 6, DMF) in addition to deblocking afforded target nucleosides 22-24. In addition, antiviral evaluations against various viruses were performed.
The concentrations of the macronutrients sodium, potassium, calcium, magnesium, phosphorus, and iron were determined in spices by microwave-assisted digestion with nitric acid hydrogen peroxide analyzed inductively coupled plasma-optical emission spectrometry (ICP-OES). analytical methods validated recovery checks analysis spinach leaves Standard Reference Material (NIST-1570a). dependent upon identity spice. Potassium, magnesium most abundant elements, followed iron, phosphorus....
Joon Ho Hong, Mi Jin Lee, Young Ick Jo, Sung Min Moon, Seul Ah and Chun Kim. Journal of the Korean Society Food Science Nutrition 2021;50:395-402. https://doi.org/10.3746/jkfn.2021.50.4.395
Abstract This study determined hydrocarbons induced by gamma and electron beam irradiation of ground beef. The samples were irradiated with 0, 2.5, 5, 7.5, 10, 15, 20 kGy dosages gamma-rays an beam. lipid contents extracted hexane the separated identified gas chromatography–mass spectrometry. analytical method was validated characterization detection limits, linearity, precision, recovery; satisfactory results obtained in all cases. major detected beef pentadecane 1-tetradecene from palmitic...
The simple, effective, and sensitive method for analyzing monosaccharide composition of fucoidan using UPLC-DAD-TOF/MS combined with precolumn derivatization by 3-methyl-1-phenyl-5-pyrazolone (PMP) reagent. This is used to identify quantify the in from Sargassum horneri. UPLC PMP reported (simple, rapid, convenient reproducible) it also proved be suitable analysis fucoidan. Also, this can determination contents other seaweed polysaccharides changing pH value mobile phase. In order ensure...
An efficient synthetic route for preparing novel <TEX>$4'{\alpha}$</TEX>-C phenyl branched carbocyclic nucleoside is described. The installation of group at the <TEX>$4'$</TEX>-position was successfully accomplished via a sequential [3,3]-sigmatropic rearrangement and ring-closing metathesis (RCM) beginning from simple ketone such as 2-hydroxy acetophenone.
The first synthesis of a 4'-branched carbocyclic C-nucleoside 11 was achieved via the key intermediate 6, which prepared using Knovenagel type condensation from ketone derivative 4.
The synthesis of 4'-phenyl and 1'-methyl doubly branched carbocyclic nucleoside was accomplished from 2-hydroxy acetophenone. group installed via a [3,3]-sigmatropic rearrangement reaction, the carbonyl addition methylmagnesium bromide used to introduce group. Cyclization divinyl 9 performed using <TEX>$2^{nd}$</TEX> generation Grubbs catalyst. coupling cyclopentenol 12<TEX>$\alpha$</TEX> with 6-chloropurine by Mitsunobu reaction desilylation synthesize target 15.
This paper discusses the racemic and stereoselective synthetic route for novel 4'α -methyl 6'α analogues of abacavir. The quaternary carbon at 4'-position carbocyclic nucleoside was installed successfully via a Claisen rearrangement. stereocontrolled construction methyl group in - position directed through Felkin-Anh rule. A Bis-vinyl compound 9 cyclized using Grubbs' catalyst II to provide carbocycle nucleus target compound. synthesized 15 showed moderate anti-HIV activity (EC50 = 10.67 μM,...
Synthesis of nanoparticles using plant extract is environment-friendly, cost-effective, and sustainable. This study reports the synthesis aqueous ethanolic extracts mediated gold aerial parts F. tenacissima (FTAAuNPs) chloroauric acid. The synthesized obtained from under sunlight in 1:15 1:10 ratios with localized surface plasmon resonance (LSPR) peaks at 533 nm exhibited sizes 15.7 27.6 nm, respectively, as revealed by scanning electron, transmission atomic force microscopic (SEM, TEM, AFM)...