BIO013 Pramipexole and selegiline reduce reactive oxygen species production in vitro

• DOI: 10.5216/ref.v9i1.21902
• Publication Date: 2012-12-27
• Authors: Kamila Landucci B...; Chiara C. Bortolasci; Luciana Higachi; Carine Coneglian ...; Edson Lopes Lavado; Lúcio Baena de Melo; Ramón Kaimen Maciel; Décio Sabbatini B...
• Keywords: Selegiline; Pramipexole; Rasagiline; Monoamine oxidase B

Parkinson's disease (PD) is characterized by degeneration of dopaminergic neurons in the substantia nigra and motor non-motor symptoms. Free radicals may play a role biochemical events that lead to neuronal death old age neurodegenerative diseases. Furthermore, oxidative stress apparent PD. New therapeutic approaches slow or halt progression have been proposed. Antioxidants, free radical scavengers, trophic factors, monoamine oxidase inhibitors all identified as potential agents for treatment Analyzing chemical structure certain anti-parkinsonian drugs, decided investigate independent its anticholinergic agonism effects. Thus, aim this work was evaluate vitro antioxidant Selegiline Pramipexole.