A5100662374- Renal and related cancers
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Pharmacological Effects and Toxicity Studies
- Renal Diseases and Glomerulopathies
- Immune Response and Inflammation
- Chronic Kidney Disease and Diabetes
- Drug-Induced Hepatotoxicity and Protection
- Proteoglycans and glycosaminoglycans research
- Hippo pathway signaling and YAP/TAZ
- Diet and metabolism studies
- Tryptophan and brain disorders
- Nephrotoxicity and Medicinal Plants
- Amyotrophic Lateral Sclerosis Research
- Cerebrovascular and genetic disorders
- Cell death mechanisms and regulation
- Plant Disease Resistance and Genetics
- Connective Tissue Growth Factor Research
- Retinopathy of Prematurity Studies
- Case Reports on Hematomas
- Vitamin D Research Studies
- Adenosine and Purinergic Signaling
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition and Health in Aging
- Histone Deacetylase Inhibitors Research
Jilin University
2023
Shanghai First People's Hospital
2008-2021
Shanghai Jiao Tong University
2012-2021
Nanjing Medical University
2021
Dalian University
2009
Bioscience (China)
2009
Dalian University of Technology
2009
Changhai Hospital
2005
Second Military Medical University
2005
Background and Purpose Muscle protein catabolism in patients with diabetic nephropathy (DN) results striking loss of muscle proteins, which increases morbidity mortality risks. Evidence shows that short‐chain fatty acids (SCFAs) play an important role health maintenance disease development. Recently, the connection between butyrate (a SCFA) DN has been revealed, although relationship atrophy remains unclear. Experimental Approach We studied changes serum levels using metabolomic analyses. In...
Autophagy has been identified as a cellular process of bulk degradation cytoplasmic components and its persistent activation is critically involved in the renal damage induced by ureteral obstruction. However, role underlying mechanisms autophagy hyperuricemic nephropathy (HN) remain unknown. In present study, we observed that inhibition 3-methyladenine (3-MA) abolished uric acid-induced differentiation fibroblasts to myofibroblasts transforming growth factor-β1 (TGF-β1), epidermal factor...
It has been reported that butyrate played an protect role in diabetic kidney disease (DKD) while the mechanism was still not clear. Transforming growth factor-β1 (TGF-β1) is initial factor which triggers profibrotic signaling cascades. P311 RNA-binding protein, could stimulate TGF-β1 translation several cell types. In our study, we found supplementary of alleviated fibrosis and suppressed expression db/db mice as well high glucose (HG)-induced SV40-MES-13 cells. Overexpression offset...
Abstract Renal inflammation significantly contributes to the progression of hepatitis B virus (HBV)-associated glomerulonephritis (HBV-GN), but mechanisms that control its precise regulation remain largely unknown. In this study, we showed lysine-specific demethylase 1 (LSD1) was upregulated in renal tissue HBV-GN patients, and expression positively correlated with inflammation. Functionally, LSD1 could promote HBV-induced release proinflammatory mediators HK-2 cells, a human tubular...
A novel actinomycete, strain S187T, was isolated from a marine sediment sample collected Xinghai Bay, Dalian, China. Growth occurred on ISP medium 2 containing 0–9 % NaCl and at pH 6.0–9.0 10–45 °C. The cell wall of S187T contained the isomer ll-diaminopimelic acid as diagnostic diamino acid. predominant menaquinones were MK-9(H6) (40.8 %), MK-9(H8) (38.2 %) MK-9(H2) (8.8 %). major fatty acids iso-C16 : 0 (29.6 anteiso-C15 (14.0 anteiso-C17 (11.6 Cells phosphatidylethanolamine,...
Butyrate is short‑chain fatty acid, which produced by intestinal microbiota metabolizing dietary fibers. participates in various physiological processes predominantly activating G‑coupled‑receptors, inhibiting histone deacetylases (HDACs) and serving as an energy substrate. Previous studies have shown that butyrate plays a protective role diabetic nephropathy (DN); however, the exact mechanism remains unclear. The present study identified providing sodium (NaBu) gavage relieved renal damage...
Abstract In this study, we investigated the function of Mitsugumin 53 (MG53) in regulation mitochondrial autophagy skeletal muscle cells and explored its potential application prevention treatment atrophy rats with chronic kidney disease (CKD). The expression beclin 1 regulator (Ambra1) MG53 muscles 5/6 nephrectomized was measured, effect on C2C12 myoblasts by vitro experiments. Our results show Ambra1 CKD significantly decreased. experiments showed that overexpression could promote cells,...
Disabled-2 (Dab2) and PAR-3 (partitioning defective 3) are reported to play critical roles in maintaining retinal microvascular endothelial cells biology by regulating VEGF-VEGFR-2 signaling. The role of Dab2 glomerular cell (GEnC) is unclear. In this study, we found that, no matter whether with vascular growth factor (VEGF) treatment or not, decreased expression could lead apoptosis preventing activation signaling GEnC, accompanied reduced membrane VEGFR-2 expression. And silencing gene...