A5049059263- Schizophrenia research and treatment
- Pulmonary Hypertension Research and Treatments
- Liver Disease Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Obsessive-Compulsive Spectrum Disorders
- Mental Health and Psychiatry
- Dermatology and Skin Diseases
- Pharmaceutical Practices and Patient Outcomes
- Radiology practices and education
- Kidney Stones and Urolithiasis Treatments
- Macrophage Migration Inhibitory Factor
- Phosphodiesterase function and regulation
- Psychotherapy Techniques and Applications
- Sexual function and dysfunction studies
- Meta-analysis and systematic reviews
- Psychosomatic Disorders and Their Treatments
- Primary Care and Health Outcomes
- Advances in Oncology and Radiotherapy
- Cancer, Lipids, and Metabolism
- Personality Disorders and Psychopathology
- Healthcare Systems and Technology
- Circular RNAs in diseases
- Lung Cancer Diagnosis and Treatment
- Case Reports on Hematomas
Sheffield Teaching Hospitals NHS Foundation Trust
2024
University College London
2022-2023
Université Paris Cité
2023
Inserm
2023
East London NHS Foundation Trust
2018-2020
Cardiovascular Institute of the South
2016-2020
Stanford University
2020
Centre for Mental Health
2019
Keele University
2015
Rationale: In pulmonary arterial hypertension (PAH), endothelial dysfunction and obliterative vascular disease are associated with DNA damage impaired signaling of BMPR2 (bone morphogenetic protein type 2 receptor) via two downstream transcription factors, PPARγ (peroxisome proliferator-activated receptor gamma), p53. Objective: We investigated the vasculoprotective regenerative potential a newly identified PPARγ-p53 factor complex in endothelium. Methods Results: this study, we...
An association between gout and renal disease is well-recognised but few studies have examined whether a risk factor for subsequent chronic kidney (CKD). Additionally, the impact of urate-lowering therapy (ULT) on development CKD in unclear. The objective this study was to quantify stage ≥ 3 people with ULT. This retrospective cohort using data from Clinical Practice Research Datalink (CPRD). Patients incident were identified general practice medical records 1998 2016 randomly matched 1:1...
Summary Although we commonly work with patients emotionally unstable personality disorder (EUPD) in community mental health teams (CMHTs), only some enter evidence-based psychological therapies. Many are not considered ready to engage specialist treatments and remain CMHTs without any clear focus or structure their treatment, which is unsatisfactory for patients, clinicians services. We present a fictional case synthesise available literature lived experience explore readiness ways promote...
Previous analysis of pharmacokinetic data on risperidone-treated patients with dementia predicted that 20% had concentration-to-dose (C/D) ratios the active moiety (risperidone and 9-hydroxy(OH)-risperidone) above 14 ng/mL per mg/day, which were in turn associated a greater risk extrapyramidal side effects. This study aimed to further explore risperidone pharmacokinetics second dataset. Nonlinear mixed effects modelling, using Bayesian approach, was applied from randomized controlled trial...
Sexual side-effects are common among those using antipsychotic medication and may result in poor compliance reduced quality of life. Retrograde ejaculation (RE) has been described occurring with a number medications (thioridazine, risperidone, iloperidone clozapine) but there no guidelines regarding management antipsychotic-associated RE. Imipramine suggested as treatment for RE one small study patients prescribed thioridazine case series iloperidone. Quetiapine is commonly used thought to...
Pulmonary arterial (PA) hypertension (PAH) is a life-threatening disease characterized by loss of microvessels, the result endothelial cell (EC) apoptosis associated with dysfunction or mutation in BMPR2. We identified p53 as critical formation DNA damage-inducible transcriptionally active complex PPARγ, an important downstream factor BMPR2 signaling. The p53-PPARγ regulates genes promoting PAEC homeostasis. Upon reoxygenation after hypoxia, defective fail to stabilize leading mitochondrial...