A5023245897- Protein Degradation and Inhibitors
- Chromatin Remodeling and Cancer
- Multiple Myeloma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Histone Deacetylase Inhibitors Research
- Graphene and Nanomaterials Applications
- TGF-β signaling in diseases
- Advanced Breast Cancer Therapies
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Hedgehog Signaling Pathway Studies
- Cancer-related molecular mechanisms research
- Neuropeptides and Animal Physiology
- Neuroblastoma Research and Treatments
- Nerve injury and regeneration
- Ferroptosis and cancer prognosis
- PARP inhibition in cancer therapy
- Chronic Lymphocytic Leukemia Research
- Developmental Biology and Gene Regulation
- Signaling Pathways in Disease
- Blood disorders and treatments
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
St. Jude Children's Research Hospital
2007-2022
University of Kentucky
2017
Vector Oncology (United States)
2013
Abstract Although null mutations in Igα have been identified patients with defects B cell development, no Igβ reported. We recently a patient homozygous amino acid substitution Igβ, glycine to serine at codon 137, adjacent the cysteine required for disulfide bond between and Igβ. This has small percentage of surface IgMdim cells peripheral circulation (0.08% compared 5–20% healthy controls). Using expression vectors 293T or Jurkat T cells, we show that mutant can form disulfide-linked...
Bone Morphogenetic Proteins (BMPs) are morphogens that play a major role in regulating development and homeostasis. Although BMPs used for the treatment of bone kidney disorders, their clinical use is limited due to supra-physiological doses required therapeutic efficacy causing severe side effects. Because recombinant expensive produce, small molecule activators BMP signaling would be cost-effective alternative with added benefit being potentially more easily deliverable. Here, we report...
Here, we describe three new small-molecule activators of BMP signaling found by high throughput screening a library ∼600 000 small molecules. Using cell-based luciferase assay in the BMP4-responsive human cervical carcinoma clonal cell line, C33A-2D2, identified compounds with similar chemotypes that each ventralize zebrafish embryos and stimulate increased expression target genes, bmp2b szl. Because these embryos, have termed them "ventromorphins." As expected for pathway activator, they...
Summary Reduced B cell numbers and a mutation in Btk are considered sufficient to make the diagnosis of X-linked agammaglobulinaemia. In process conducting family studies, we identified 58-year-old healthy man with an amino acid substitution, Y418H, adenosine-5′-triphosphate binding site Btk. Immunofluorescence studies showed that this had 0·85% CD19+ cells (normal 4–18%) peripheral circulation his monocytes were positive for He borderline low serum immunoglobulins but normal titres tetanus...
<p>Supplementary Methods, Figures S1-S9 and Tables S3, S5-S7</p>
<p>Supplementary Methods, Figures S1-S9 and Tables S3, S5-S7</p>
<div>Abstract<p>Despite improvement in the treatment of medulloblastoma over last years, numerous patients with MYC- and MYCN-driven tumors still fail current therapies. Medulloblastomas have an intact retinoblastoma protein RB, suggesting that CDK4/6 inhibition might represent a therapeutic strategy for which drug combination remains understudied. We conducted high-throughput screens Group3 (G3) line using inhibitor (CDK4/6i) ribociclib at IC<sub>20</sub>, referred...
<div>Abstract<p>Despite improvement in the treatment of medulloblastoma over last years, numerous patients with MYC- and MYCN-driven tumors still fail current therapies. Medulloblastomas have an intact retinoblastoma protein RB, suggesting that CDK4/6 inhibition might represent a therapeutic strategy for which drug combination remains understudied. We conducted high-throughput screens Group3 (G3) line using inhibitor (CDK4/6i) ribociclib at IC<sub>20</sub>, referred...
Abstract Medulloblastoma has been extensively characterized at the genomic and transcriptional levels, but little is known about how alterations in translational control underlie tumor development. Myc Mycn are often deregulated medulloblastoma play important roles initiation, maintenance progression. Although both proteins have similar structures functionally redundant hindbrain development, their amplification cerebellar granule neural precursor cells leads to different subtypes. In this...