A5024250754- Ophthalmology and Eye Disorders
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Cancer Immunotherapy and Biomarkers
- Childhood Cancer Survivors' Quality of Life
Children's Hospital of Michigan
2023
Immune checkpoint inhibitors (ICIs) are a relatively new class of immunotherapy which bolsters the host immune system by "turning off brakes" effector cells (e.g., CTLA-4, PD-1, PD-L1). Although their success in treating adult malignancy is well documented, utility pediatric cancer has not yet been shown to be as fruitful. We review ICIs, use malignancies, and active clinical trials, exemplifying some efforts that could related future trials complications ICI therapy. Through our review, we...
<h3>BACKGROUND AND PURPOSE:</h3> While Graves disease is the most common cause of extraocular muscle enlargement, case reports have also associated growth hormone-secretory pituitary adenomas with this same phenomenon. We investigated prevalence and response to treatment enlargement in patients adenomas. <h3>MATERIALS METHODS:</h3> retrospectively reviewed sizes using MR imaging hormone–secretory who underwent a transsphenoidal surgical resection compared matched control group nonsecretory...