A5014896501- Ovarian function and disorders
- Phytoestrogen effects and research
- Effects and risks of endocrine disrupting chemicals
- Reproductive Biology and Fertility
- Estrogen and related hormone effects
- Birth, Development, and Health
- Assisted Reproductive Technology and Twin Pregnancy
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Menopause: Health Impacts and Treatments
- Hypothalamic control of reproductive hormones
- Reproductive Physiology in Livestock
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Cancer Risks and Factors
- Science, Research, and Medicine
- Health, Environment, Cognitive Aging
- Ovarian cancer diagnosis and treatment
- COVID-19 Clinical Research Studies
- Nutrition, Genetics, and Disease
- Food composition and properties
- Urological Disorders and Treatments
- Diet, Metabolism, and Disease
- Fatty Acid Research and Health
- Gynecological conditions and treatments
Duke Medical Center
2004-2023
IQVIA (United States)
2011-2023
Duke University Hospital
1991-2023
Public Health Agency of Canada
2023
IQVIA (United Kingdom)
2004-2020
North Carolina State University
2013-2019
IQVIA (France)
2017-2019
Duke University
1988-2015
Wake Forest University
1995-2013
Triangle
2004-2012
Background: In response to the isolation of BRCA1 gene, a breast-ovarian cancer-susceptibility biotechnology companies are already marketing genetic tests health care providers and public. Initial studies indicate interest in testing general public populations at high risk. However, optimal strategies for educating counseling individuals have yet be determined. Purpose: Our goal was evaluate impact alternate pretest education on decision-making regarding among women low moderate risk who...
We tested the hypothesis that postmenopausal women on a soy-supplemented diet show estrogenic responses. Ninety-seven were randomized to either group was provided with soy foods for 4 weeks or control instructed eat as usual. Changes in urinary isoflavone concentrations served measure of compliance and phytoestrogen dose. serum FSH, LH, sex hormone binding globulin, vaginal cytology measured assess response. The percentage superficial cells (indicative estrogenicity) increased 19% those...
PURPOSE To identify members of hereditary breast and ovarian cancer families who are at risk for adverse psychologic effects genetic testing. PATIENTS AND METHODS A prospective cohort study with baseline (preeducation) assessments predictor variables (ie, sociodemographic factors, history, cancer-related stress symptoms) was performed. The primary outcome variable (presence depressive assessed 1- 6-month follow-up evaluations. Participants were 327 adult male female BRCA1- BRCA2-linked...
ContextGenetic testing for hereditary nonpolyposis colon cancer (HNPCC) is available, but the rates of acceptance or barriers to participation are not known.ObjectiveTo investigate and predictors utilization genetic HNPCC.DesignCohort study conducted between July 1996 1998.SettingHereditary family registry.ParticipantsAdult male female members (n=208) 4 extended HNPCC families contacted a baseline telephone interview.InterventionsFamily education individual counseling.Main Outcome...
Lactoferrin (LTF), an iron-binding glycoprotein present in most exocrine secretions and the secondary granules of polymorphonuclear leucocytes (PMN), is regulated by estrogen mouse reproductive tract. We investigated expression LTF mRNA protein during natural estrous cycle to increase our understanding how this uterine secretory under physiological conditions. There was a positive correlation between genital tract serum estradiol (E2) concentrations. When E2 peaked proestrus, were expressed...
Exposure to naturally occurring estrogens during critical periods of development can alter morphologic and physiologic markers sexual differentiation. The current experiment characterizes the effects in utero treatment with genistein, an isoflavonoid phytoestrogen, on birth weight, anogenital distance (AGD) at birth. GnRH stimulated luteinizing hormone (LH) secretion, volume sexually dimorphic nucleus preoptic area hypothalamus (SDN-POA), puberty onset, vaginal cyclicity. Pregnant Charles...
Female reproductive aging based on changes in menstrual cycle length and frequency progresses through a number of stages as defined by the Stages Reproductive Aging Workshop (STRAW) staging criteria.This paper provides comprehensive description endocrine features associated with STRAW stages.Healthy women aged 21-35 45-55 yr submitted three blood samples week over single cycle. They were classified mid-reproductive age (n = 21), late-reproductive 16), early menopause transition late...
The neonatal hormone environment determines the sexually differentiated pattern of brain growth. Estrogens, derived from intracerebral aromatization testosterone, promote male sexual central nervous system (CNS) development. Developing animals may also encounter estrogens plant, fungal, and xenobiotic sources (environmental estrogens). purpose this study was to assess effects environmental on physiology morphology hypothalamus pituitary. Neonatal rats received injections either corn oil, 0.1...
Human populations throughout the world are exposed daily to low levels of environmental contaminants. The consequences potential interactions these compounds human endocrine, reproductive, and immune function remain unknown. current study examines effects subchronic oral exposure a complex mixture ubiquitous persistent contaminants that have been quantified in reproductive tissues. dosing solution used this contained organochlorines (2,3,7,8-tetrachlorodibenzo-p-dioxin [TCDD],...
Plants have physical and chemical mechanisms for defense from attack by animals. Phytochemical defenses that protect plants insects include antifeedants, insecticides, insect growth regulators. options exist which can modulate the fertility of other major group plant predators, vertebrate herbivores, thereby reduce cumulative attacks those herbivores. The success such a depends upon phytochemical mimicry reproductive hormones. Phytoestrogens do mimic hormones are proposed to be defensive...
The menopausal transition is characterized by irregular menstrual cycles and unpredictable hormone levels, including dramatic swings in estradiol (E2). An increasing number of studies have found variable high E2 low luteal phase progesterone occur with progression Stages Reproductive Aging Workshop (STRAW)stage, but the cause remains unclear. To explore causes erratic changes E2, individual within-cycle secretion patterns progesterone, follicle-stimulating hormone, luteinizing inhibin A, B...
Man-made chemicals that have been shown to modulate endocrine function in animal models, so-called "endocrine disrupters", are suspected play a role the development of male reproductive tract abnormalities and neurobehaviroal deficits children. However utero exposure environmental contaminants has not documented previously. The present study was performed test our hypothesis man-made can be quantified human amniotic fluid during second trimester. Gas chromatographic/mass spectrometric...
To determine the association between various forms of tobacco exposure and ovarian status, as measured by FSH concentrations, in women 38-49 years old.Two hundred ninety old, who had not hysterectomy or oophorectomy, completed a self-administered questionnaire that included information on serum levels days 2-4 menstrual cycle. Linear regression was used to assess relation exposure.Controlling for age other factors, concentrations were 66% higher among current smokers (geometric mean 14.0...