A5047226656- Hippo pathway signaling and YAP/TAZ
- Cancer, Lipids, and Metabolism
- Caveolin-1 and cellular processes
- Ferroptosis and cancer prognosis
- Cellular Mechanics and Interactions
- Blood properties and coagulation
- Cell Adhesion Molecules Research
- Erythrocyte Function and Pathophysiology
Ministry of Education of the People's Republic of China
2022-2023
Peking University
2022-2023
National Health and Family Planning Commission
2022-2023
Abstract Mechanotransduction in endothelial cells is critical to maintain vascular homeostasis and can contribute disease development, yet the molecules responsible for sensing flow remain largely unknown. Here, we demonstrate that discoidin domain receptor 1 (DDR1) tyrosine kinase a direct mechanosensor essential connecting force imposed by shear responses. We identify flow-induced activation of DDR1 be atherogenic. Shear likely causes conformational changes ectodomain unfolding its DS-like...
The Hippo-YAP (yes-associated protein) signaling pathway is modulated in response to various environmental cues. Activation of YAP vascular smooth muscle cells conveys the extracellular matrix stiffness-induced changes phenotype and behavior. Recent studies have established a mechanoreceptive role receptor tyrosine kinase DDR1 (discoidin domain 1) cells.We conduced 5/6 nephrectomy cells-specific Ddr1-knockout mice, accompanied by pharmacological inhibition Hippo LATS1 (large tumor suppressor...