About
Contact & Profiles
A5103281609
Research Areas
- Acute Myeloid Leukemia Research
- Pharmacogenetics and Drug Metabolism
- PARP inhibition in cancer therapy
- Cancer, Lipids, and Metabolism
- Histone Deacetylase Inhibitors Research
- Computational Drug Discovery Methods
- Protein Degradation and Inhibitors
- Advanced Breast Cancer Therapies
- Estrogen and related hormone effects
Vellore Institute of Technology University
2023-2024
10.1007/s11030-024-10890-0
article
EN
Molecular Diversity
2024-05-25
Abstract Acute myeloid leukemia (AML) accounts for 1.3% of all cancers, with a limited survival only 30%, and treating AML is continuous challenge in medicine. IKZF1 DNA-binding protein that highly mutated undruggable but significant causing AML. The current study aims to target its transcription factors (TFs) modulating activity. TF network was constructed analyzed which revealed dense Markov cluster (MCL) five hub genes namely, HDAC1, EP300, CREBBP, TP53, MYC; the first node clusters were...
10.1093/intbio/zyae022
article
EN
Integrative Biology
2024-01-01
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