A5015209298- Retinal Diseases and Treatments
- Congenital Heart Disease Studies
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Retinoids in leukemia and cellular processes
- Glaucoma and retinal disorders
- Cardiovascular Effects of Exercise
- Cardiovascular Conditions and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiovascular Issues in Pregnancy
- Corneal surgery and disorders
- Mosquito-borne diseases and control
- Cardiovascular and Diving-Related Complications
- Ocular Diseases and Behçet’s Syndrome
- Connexins and lens biology
- Mechanical Circulatory Support Devices
Dokuz Eylül University
2023
Haydarpaşa Numune Eğitim ve Araştırma Hastanesi
2016-2017
Sivas State Hospital
2007
In this study, we aimed to observe whether curcumin (cur), a polyphenolic compound derived from the dietary spice turmeric, yellow substance obtained root of plant Curcuma longa Linn, has any protective effect against blue light irradiation in human retinal pigment epithelium (ARPE-19) cells. For purpose, evaluated intracellular calcium release mechanism, poly ADP ribose polymerase (PARP), procaspase-3/-9 protein expression levels, caspase activation, and reactive oxygen species levels....
Stargardt disease (STGD) is an inherited genetic eye condition involving bilateral macular dystrophy leading to progressive central vision loss.It the most common form of autosomal recessive juvenile dystrophy.In this study, ELOVL4 and PRPH2 genes were analyzed in 30 STGD probands for variations using nextgeneration sequencing.In patient group, two variants exon 6 ELOVL4, three 3 detected.All sequence modifications both recorded, including H. Bardak et al. Genetics Molecular Research 15 (4):...
The aim of this study was to screen the visual system homeobox 1 (VSX1) gene in Turkish patients with keratoconus (KC). patient group consisted 44 who had undergone corneal transplant surgery before age 30, for advanced and rapidly progressive KC. control comprised 250 healthy individuals. We detected two missense mutations, D144N D295Y, exon 2 5 VSX1 gene, respectively, using next-generation sequencing analysis. pathologic effects D295Y mutations on protein function were determined...
Age-related macular degeneration (AMD) is a leading cause of blindness in developed countries.The ARMS2 gene has been found to be associated with AMD.Currently, intravitreal ranibizumab (IVR) treatment one the widely used treatments for neovascular AMD.The aim this study was investigate association between genotype rs10490924 polymorphism and IVR responsiveness patients included 39 advanced AMD (patient group) 250 healthy individuals exome sequencing data (control group).The H. Bardak et...
Objectives: Atrial and ventricular arrhythmias can be observed in children after transcatheter atrial septal defect (ASD) closure.This study investigated repolarization parameters, which are considered to indicate an increased risk of patients with ASD closure. Materials Methods:The included 225 aged 0-18 years who underwent closure at a tertiary medical school university hospital between 2005 2020.Heart rate, Pmax, Pmin, Pdispersion, QTmax, QTmin, QTdispersion, QTcmax, QTcmin,...
To evaluate alterations in central retinal sensitivity following intravitreal triamcinolone injection patients with diffuse diabetic macular edema that persisted after laser treatment.Fourteen eyes of 14 received 4 mg 0.1 cc underwent threshold test using computerized visual field analyzer before and 1, 2, 3, 5 months injection. Pre- postinjection values total defect depth, threshold, best-corrected acuity were compared correlated.At the last follow-up, to baseline, improved from 1.4+/-0.4...
Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. It a complex disease with both genetic and environmental risk factors. To improve clinical management this condition, it important to develop assessment prevention strategies for influences, establish more effective treatment approach. The aim present study was investigate age-related maculopathy susceptibility protein 2 (ARMS2) gene sequences among Turkish patients exudative AMD. In addition 39...
Background: Congenital Heart Disease (CHD) constitutes a significant cause of morbidity and mortality in newborns. Identifying CHD prenatally understanding associated risk factors can aid early diagnosis, intervention, postnatal management. This study aims to assess for using prenatal fetal echocardiography (FE) investigate their correlation with diagnoses. Patients Methods: In this study, we included 993 pregnant women presenting the pediatric cardiology outpatient clinic between December...
With the development of transcatheter interventional techniques and introduction next-generation duct occluder devices, closure has become first treatment option for patent ductus arteriosus (PDA) in pediatric patients. In this study, we compared effectiveness safety different devices PDA patients, focusing on long-term outcomes.A total 235 patients aged 0-18 years who underwent at a tertiary care center between January 2005 February 2020 were included. The medical records cases...