A5033452431- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Analytical chemistry methods development
- Microfluidic and Capillary Electrophoresis Applications
- Ion-surface interactions and analysis
- Advanced Chemical Sensor Technologies
- Metabolomics and Mass Spectrometry Studies
- Electrochemical Analysis and Applications
- Analytical Chemistry and Sensors
- Electrohydrodynamics and Fluid Dynamics
- Petroleum Processing and Analysis
- Hydrocarbon exploration and reservoir analysis
- Porphyrin and Phthalocyanine Chemistry
- Electrochemical sensors and biosensors
- Advanced Proteomics Techniques and Applications
- Pesticide Residue Analysis and Safety
- Radioactive element chemistry and processing
- Force Microscopy Techniques and Applications
- Surface Roughness and Optical Measurements
- Microfluidic and Bio-sensing Technologies
- Hemoglobin structure and function
- thermodynamics and calorimetric analyses
- Innovative Microfluidic and Catalytic Techniques Innovation
- Laser-induced spectroscopy and plasma
- Indoor Air Quality and Microbial Exposure
Oak Ridge National Laboratory
2009-2018
Together Enhancing Awareness Coalition
2007-2012
University of Tennessee at Knoxville
2004-2011
Merck (Germany)
2010
The University of Texas at Austin
2004
Florida International University
2000-2001
University of Geneva
1994
Washington State University
1985-1991
Multiply charged anions derived from electrospray ionization of the sodium salts various small oligonucleotides (n = 4−8) have been subjected to tandem mass spectrometry (MS/MS) in a quadrupole ion trap. All ions were observed dissociate with high efficiencies even under conditions not ordinarily conducive for observance MS/MS efficiency. Large fractions total product signal could be attributed single-cleavage reactions parent charge shared among two combinations. In every case, most facile...
Abstract A fully automated liquid extraction‐based surface sampling device utilizing an Advion NanoMate chip‐based infusion nanoelectrospray ionization system is reported. Analyses were enabled for discrete spot by using the Advanced User Interface of current commercial control software. This software interface provided parameter necessary robotic pipettor to both form and withdraw a microjunction from surface. The was tested with three types analytically important sample types, viz .,...
The number and type of atmospheric pressure techniques suitable for sampling analytes from surfaces, forming ions these analytes, subsequently transporting into vacuum interrogation by MS have rapidly expanded over the last several years. Moreover, literature in this area is complicated an explosion acronyms techniques, many which provide no information relating to chemical or physical processes involved. In tutorial article, we sort vast array relatively few categories on basis approaches...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemical origin of radical cations observed in electrospray ionization mass spectraGary J. Van Berkel, Scott A. McLuckey, and Gary L. GlishCite this: Anal. Chem. 1992, 64, 14, 1586–1593Publication Date (Print):July 15, 1992Publication History Published online1 May 2002Published inissue 15 July 1992https://pubs.acs.org/doi/10.1021/ac00038a015https://doi.org/10.1021/ac00038a015research-articleACS PublicationsRequest reuse permissionsArticle...
Editorial Comment Last month we presented, as a Special Feature, set of five articles that constituted Commentary on the fundamentals and mechanism electrospray ionization (ESI). These produced some lively discussion among authors role electrochemistry in ESI. Six participated detailed exchange views this topic, final results which constitute month's Feature. We particularly hope younger scientists will find value not only for science it teaches but also what reveals about processes by...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrospray ionization combined with ion trap mass spectrometryGary J. Van Berkel, Gary L. Glish, and Scott A. McLuckeyCite this: Anal. Chem. 1990, 62, 13, 1284–1295Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/ac00212a016https://doi.org/10.1021/ac00212a016research-articleACS PublicationsRequest reuse permissionsArticle...
Desorption electrospray ionization (DESI) was demonstrated as a means to couple thin-layer chromatography (TLC) with mass spectrometry. The experimental setup and its optimization are described. Development lanes were scanned by moving the TLC plate under computer control while directing stationary DESI emitter charged droplet plume at surface. Mass spectral data recorded in either selected reaction monitoring mode or full scan ion trap using hybrid triple quadrupole linear spectrometer....
A combined surface sampling probe/electrospray emitter was used for the direct readout of thin-layer chromatography plates by electrospray mass spectrometry. The technique demonstrated with reversed-phase C18 using a three-dye mixture composed methylene blue, crystal violet, and rhodamine 6G positive ion mode detection separate dye containing fluorescein, naphthol blue black, fast green FCF negative detection. Acquisition spectra components individual bands on plate shown manual stepping to...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of an Electrospray Ion Source as a Controlled-Current Electrolytic CellGary J. Van Berkel and Feimeng. ZhouCite this: Anal. Chem. 1995, 67, 17, 2916–2923Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/ac00113a028https://doi.org/10.1021/ac00113a028research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of dimethylamine with multiply charged ions cytochrome cScott A. McLuckey, Gary J. Van Berkel, and L. GlishCite this: Am. Chem. Soc. 1990, 112, 14, 5668–5670Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/ja00170a057https://doi.org/10.1021/ja00170a057research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEArticleNEXTChemical Derivatization for Electrospray Ionization Mass Spectrometry. 1. Alkyl Halides, Alcohols, Phenols, Thiols, and AminesJ. Martin E. Quirke, Christopher L. Adams, Gary J. Van BerkelCite this: Anal. Chem. 1994, 66, 8, 1302–1315Publication Date (Print):April 15, 1994Publication History Published online1 May 2002Published inissue 15 April 1994https://doi.org/10.1021/ac00080a016RIGHTS & PERMISSIONSArticle Views2542Altmetric-Citations144LEARN ABOUT...
ADVERTISEMENT RETURN TO ISSUEPREVFEATURESNEXTUsing the Electrochemistry of Electrospray Ion SourceGary J. Van Berkel and Vilmos KerteszCite this: Anal. Chem. 2007, 79, 15, 5510–5520Publication Date (Web):August 1, 2007Publication History Published online1 August 2007Published inissue 1 2007https://doi.org/10.1021/ac071944aCopyright © 2007 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views2592Altmetric-Citations117LEARN ABOUT THESE METRICSArticle Views are COUNTER-compliant sum full...
Desorption electrospray ionization tandem mass spectrometry (DESI-MS/MS) and whole-body autoradiography (WBA) were used for chemical imaging of thin tissue sections mice intravenously dosed with propranolol (7.5 mg/kg). DESI-MS/MS utilized selected reaction monitoring detection performed on an AB/MDS SCIEX 4000 QTRAP spectrometer equipped a prototype extended length particle discriminator interface. Propranolol images the using obtained at surface scan rates 0.1, 0.5, 2, 7 mm/s. Although...
Abstract A self‐aspirating, liquid microjunction surface sampling probe/electrospray emitter mass spectrometry system was demonstrated for use in the direct analysis of spotted and dosed drugs their metabolites thin tissue sections. Proof‐of‐principle directly from without need sample preparation first by raster scanning a region on section rat liver onto which reserpine spotted. The spectral signal selected reaction monitoring used to develop chemical image drug tissue. probe also...
The imaging resolution of desorption electrospray ionization mass spectrometry (DESI-MS) was investigated using printed patterns on paper and thin-layer chromatography (TLC) plate surfaces. Resolution approaching 40 microm achieved with a typical DESI-MS setup, which is approximately 5 times better than the best reported previously. This improvement accomplished careful control operational parameters (particularly spray tip-to-surface distance, solvent flow rate, spacing lane scans). In...
In this paper, the use of ferrocene-based "electrochemically ionizable" derivatives to enhance ES-MS analysis simple alcohols, sterols, and phenols is discussed. These are designed take advantage electrolysis process inherent operation ES ion source for selective ionization. Derivatization procedures, electrochemical character derivatives, operational parameters necessary maximize ionization gas-phase detection presented with reference ferrocenecarbamate ester a variety alcohol standards, as...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrospray ionization of porphyrins using a quadrupole ion trap for mass analysisGary J. Van Berkel, Scott A. McLuckey, and Gary L. GlishCite this: Anal. Chem. 1991, 63, 11, 1098–1109Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/ac00011a009https://doi.org/10.1021/ac00011a009research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemistry Combined Online with Electrospray Mass SpectrometryFeimeng. Zhou and Gary J. Van BerkelCite this: Anal. Chem. 1995, 67, 20, 3643–3649Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/ac00116a005https://doi.org/10.1021/ac00116a005research-articleACS PublicationsRequest reuse permissionsArticle Views988Altmetric-Citations140LEARN...
Desorption electrospray ionization mass spectrometry was investigated as a means to qualitatively identify and quantify analytes directly from developed normal-phase thin-layer chromatography plates. The atmospheric sampling capillary of commercial ion trap spectrometer extended permit in bands separated on intact TLC plates (up 10 cm × cm). A surface positioning software package the appropriate hardware enabled computer-controlled scanning along length development lanes or at fixed Rf value...
Modest modifications to the atmospheric sampling capillary of a commercial electrospray mass spectrometer and upgrades an in-house-developed surface positioning control software package (HandsFree TLC/MS) were used enable automated imaging analytes on within large area substrates using desorption ionization spectrometry. Sampling rhodamine dyes separated TLC plates illustrate some practical applications this system. Examples are shown for user-defined spot from bands plate (one or multiple...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharge determination of product ions formed from collision-induced dissociation multiply protonated molecules via ion/molecule reactionsScott A. McLuckey, Gary L. Glish, and J. Van BerkelCite this: Anal. Chem. 1991, 63, 18, 1971–1978Publication Date (Print):September 15, 1991Publication History Published online1 May 2002Published inissue 15 September...