A5023796197- Sperm and Testicular Function
- Erythrocyte Function and Pathophysiology
- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- Muscle Physiology and Disorders
- Reproductive Biology and Fertility
Instituto Politécnico Nacional
2020
Universidad Autónoma Metropolitana
2019
Actin polymerization is a crucial process during sperm capacitation. We have recently described the participation of FAK actin in guinea pig spermatozoa. However, mechanism by which mediates these processes unknown. Our previous data shown that MAPK1 (hereafter referred to as ERK2) activated first minutes capacitation, and inhibition ERK2 blocked acrosome reaction. In this current study, we found involved activation - was phosphorylated at tyrosine residue 925 bound Grb2 results significant...
Abstract Actin cytoskeleton remodeling is a critical process for the acquisition of fertilizing capacity by spermatozoa during capacitation. However, molecular mechanism that regulates this has not been fully elucidated. In somatic cells, Ras‐related C3 botulinum toxin substrate 1 protein (Rac1) promotes polymerization actin participating in modeling two structures: lamellipodia and adhesion complexes linked with plasma membrane. Rac1 expressed mammalian spermatozoa; however, role sperm...