A5071248755- Hippo pathway signaling and YAP/TAZ
- Developmental Biology and Gene Regulation
- Invertebrate Immune Response Mechanisms
- Neurobiology and Insect Physiology Research
- Wound Healing and Treatments
- melanin and skin pigmentation
- Congenital heart defects research
- Silk-based biomaterials and applications
- Planarian Biology and Electrostimulation
- Morphological variations and asymmetry
- Spine and Intervertebral Disc Pathology
- Genetics, Aging, and Longevity in Model Organisms
Columbia University Irving Medical Center
2018
Columbia University
2014-2018
Universitat de Barcelona
2009-2013
Institut de Biomedicina de la Universitat de Barcelona
2010
Developing tissues that contain mutant or compromised cells present risks to animal health. Accordingly, the appearance of a population suboptimal in tissue elicits cellular interactions prevent their contribution adult. Here we report this quality control process, cell competition, uses specific components evolutionarily ancient and conserved innate immune system eliminate Drosophila perceived as unfit. We find Toll-related receptors (TRRs) cytokine Spätzle (Spz) lead NFκB-dependent...
Regeneration and tissue repair allow damaged or lost body parts to be replaced. After injury fragmentation of Drosophila imaginal discs, regeneration leads the development normal adult structures. This process is likely involve a combination cell rearrangement compensatory proliferation. However, detailed mechanisms underlying these processes are poorly understood. We have established system temporally restricted induction death in situ. Using Gal4/Gal80 UAS-rpr constructs, targeted ablation...
To understand the cellular parameters that govern Drosophila wing disc regeneration, we genetically eliminated specific stripes of along proximodistal axis and used vein intervein markers to trace tissue regeneration. We found veins could regenerate interveins vice versa, indicating respecification cell fates. Moreover, occurred in cells close wound. The newly generated domains were intercalated fill missing parts. This intercalation was driven by increased proliferation, accompanied changes...