The objective of this work was to develop a better understanding potentially scalable, liquid antisolvent (LAS) precipitation process, for the preparation stable aqueous suspensions ultrafine particles poorly water-soluble active pharmaceutical ingredients (APIs). A novel combination jets, ultrasound, polymers, and surfactants used stabilization griseofulvin (GF). Use ultrasound high stream velocities enhances micromixing, whereas addition polymers/surfactants inhibits/lowers particle...

In the foreseeable future, pharmaceuticals market, nanomedicine, and healthcare systems will largely depend on drug nanoparticle formulation technology. Perceiving this, scientists around world are reporting each day a significant amount of research work focusing fundamentals nanocrystallization performance enhancement. The strategies' industrial applications mainly ability technique to produce nanoparticles active pharmaceutical ingredients (APIs) with controlled particle size, narrow size...

Curcumin is a pharmaceutically viable ingredient derived from the rhizome of Indian spice turmeric (Curcuma longa). However, curcumin suffers poor water solubility, which limits its bioavailability. In this work, we report studies carried out to investigate cocrystallization improve aqueous solubility. Salicylic acid and hydroxyquinol were used as coformers. Binary phase diagrams constructed for curcumin–salicylic curcumin–hydroxyquinol systems using differential scanning calorimetric (DSC)...

Precipitation of curcumin, a poorly water-soluble drug, has been carried out by the liquid antisolvent technique in presence ultrasound and stabilizers. Curcumin particles with varied morphology were observed to have formed during precipitation additives such as sodium dodecyl sulfate (SDS), Tween 80, hydroxyl propyl methylcellulose (HPMC), polyvinyl pyrrolidone (PVP), bovine serum albumin (BSA). Characterization precipitated reveals that curcumin large polymeric stabilizers HPMC, PVP, BSA...

Curcumin crystallizes in three polymorphic forms. Form 1 exists as a monoclinic structure, whereas Forms 2 and 3 exist orthorhombic structures. The aim of this work was to understand the behavior curcumin stability forms curcumin. Liquid antisolvent precipitation presence ultrasound additives results (Form or 3), raw particles precipitated without form. Differential scanning calorimetery (DSC) experiments reveal that both (Forms which additives, transform form 1) upon heating. 3) particles,...

Bacterial resistance to antimicrobial drugs is one of the biggest threats human health and novel drugs, strategies are needed obviate this crisis. An innovative strategy for designing based on hybridization an agent with a second functional entity. Here, we use cell-penetrating peptide-octaarginine (R8) as entity develop complex or hybrid R8 curcumin that possibly targets bacterial cell membrane. Minimum inhibitory concentration assays show antibacterial activity enhanced in synergistic...

Curcumin is a naturally occurring compound derived from turmeric. Despite its many medicinal properties, such as being an antioxidant, anti-inflammatory, tumor reducer, etc., applications of curcumin are restricted due to low aqueous solubility and consequently poor bioavailability. By converting the solid state poorly water-soluble active pharmaceutical ingredients coamorphous mixtures, solvates, cocrystals, eutectics, can be significantly improved. In this study, U. S. Food Drug...

This study focuses on synthesizing a catalyst that can quickly degrade micropollutants in water with minimal ozone exposure. While is an effective oxidizing agent, it harm the environment at higher concentrations if released gaseous form. Thus, due to their efficiency and non-toxicity, researchers prefer use hydroxyl radicals as agents. In this study, Fe magnetite nanoparticles (FeNPs) have been synthesized generate for ozonation. The stability effectiveness of FeNPs ozonation were tested...

Microfluidic devices are becoming increasingly popular for producing microbubbles, as these provide much greater control over microbubble size compared to traditional methods such sonication and amalgamation. Recent developments in microfabrication technologies have prompted several modifications conventional microfluidic devices, which allow one “engineer” microbubbles relevant specific biomedical applications. The pursuit of improvements engineering requires a detailed understanding fluid...

Even though many experimental investigations are reported on this subject of liquid velocity patterns in bubble columns, most the work is restricted to measurements at near wall regions, columns without internals, and low dispersed phase hold‐ups. In present work, a non‐invasive radioactive particle tracking technique was employed quantify hydrodynamic parameters 120 mm diameter column with, vertical rod using air/water system as working fluids. The superficial air velocities cover wide...