Systemic immune-inflammation index (SII; platelet count × neutrophil-to-lymphocyte ratio), a novel marker, predicts adverse clinical outcomes in coronary artery diseases (CAD). We hypothesized that SII could provide more valuable information assessing the severity of CAD than ratios obtained from other white blood cell subtypes. Patients (n = 669) who underwent angiography were analyzed this retrospective study. relation between and angiographic CAD. The atherosclerosis was determined by...

Inflammation and polymorphonuclear neutrophils are shown to be important in the pathogenesis of acute myocardial infarction (AMI). Neutrophil gelatinase-associated lipocalin (NGAL) is secreted from may increase proteolytic activity within atherosclerotic plaque. We aimed investigate whether plasma levels NGAL higher patients with AMI compared stable coronary artery disease (CAD).The study population consisted 128 eligible who underwent angiography clinical diagnosis CAD. Of included study,...

Background and objective Hypertension (HT)-mediated organ damage (HMOD) refers to structural or functional in organs caused by chronic HT, which plays a critical role determining cardiovascular mortality risk. Traditional ambulatory blood pressure monitoring (ABPM) parameters have limited utility predicting its occurrence. To address this gap, we focused on indices that reflect (BP) variability arterial stiffness, such as average real (ARV), stiffness index (AASI), pulse (PPI). This study...

Background: Hypertension-mediated organ damage (HMOD) is a critical complication of hypertension that can present with cardiac, retinal, and renal manifestations affect patient outcomes. Serum signal peptide, CUB (complement C1r/C1s, Uegf, Bmp1) domain, epidermal growth factor-like domain-containing protein 1 (SCUBE-1), novel biomarker implicated in vascular pathology, shows promise for detecting HMOD. This study aims to explore the relation between SCUBE-1 levels HMOD hypertensive patients....

Neurohumoral alterations in heart failure (HF) affect blood pressure variability (BPV) and vascular compliance, but little is known about this subject among patients admitted to the hospital with decompensated HF. This study sought investigate in-hospital 24-h monitoring (BPM)-derived BPV parameters compliance HF explore association of these hospitalization length adverse events.

Atrial fibrillation (AF) is known to be related with increased risk of thromboembolic events. Asymmetrical dimethylarginine (ADMA), which an endogenous inhibitor nitric oxide synthase (NOS), can cause endothelial dysfunction by decreasing (NO) and lead thrombosis. In the present study our aim was compare plasma levels ADMA in patients acute onset (< 24 hours) chronic AF (> 1 year) determine thrombosis.17 first detected attack within hours presentation (group 1), 25 who had permanent lasting...

Many studies have shown that bilirubin may protect against atherosclerosis. In the present study, we assess association between serum total levels and severity of coronary artery disease (CAD) assessed by angiography Syntax score.Patients from our center, who visited center for a angiography, January 2008 to 2011, were eligible this analysis. Serum other blood parameters in at least 12-h fasting states determined. The patients divided into tertiles according their score.A 299 registered...

The QRS complex fragmentations (fQRS) frequently seen on admission electrocardiograms (ECGs) with narrow or wide are associated increased morbidity and mortality. causative relationship between fQRS cardiac fibrosis is known, but the relation of fragmented before after primary percutaneous coronary intervention (p-PCI) myocardial infarction reperfusion parameters has not been studied until now.The study included 184 consecutive patients ST elevation (STEMI) who underwent p-PCI. Presence...

Vitamin D is known for its effect in calcium and bone homeostasis. There an increasing evidence health benefits accomplished by activated vitamin that go beyond these classical functions. Previous studies have suggested lower levels are associated with increased cardiovascular disease risk. Therefore, we aimed to evaluate relationship between extent severity of coronary artery disease.A total 746 patients whom angiography was performed August 2012 July 2013 were enrolled this study. Serum...

Leading clinical and experimental investigators comprehensively review the chemistry, biochemistry, molecular biology, physiology, pathophysiology of nitric oxide in cardiovascular systems. Th

Fractional flow reserve (FFR) is an invasive method to assess the functional significance of coronary stenoses. The value FFR in diabetic patients controversial because microvascular dysfunction. aim this study investigate effect diabetes mellitus (DM) on measurements.One hundred and twenty-one with intermediate lesion who had undergone measurement were included study. Lesion severity was determined by quantitative angiography. divided into groups according presence (group 1) or absence 2)...

The role of systemic and chronic inflammatory processes in the pathophysiology rheumatic heart valve disease is well known. neutrophil-to-lymphocyte ratio (NLR) was shown to be an indicator inflammation. In this study, we aimed investigate relationship between NLR as a marker inflammation mitral stenosis (RMVS).This retrospective study. Among patients who underwent transthoracic echocardiography January 2008-March 2013, 314 with RMVS were included retrospectively control group 57 healthy...

Background Endothelial dysfunction and subsequently impaired microvascular circulation are the leading mechanisms in development of cardiac syndrome X (CSX). The study evaluated plasma asymmetric dimethylarginine (ADMA) L-arginine levels patients with CSX control group aimed to determine any relationship between these parameters epicardial coronary blood flow myocardial tissue perfusion. Methods consisted 32 (mean age: 52.6±9.4 years, 14 men) typical exertional angina, positive exercise...

Although it is well established that plasma B-type natriuretic peptide (BNP) levels are higher in patients with acute coronary syndromes, the relationship between BNP level and stable artery disease not clear. The aim of this study was to examine extent obstructive lesions on angiography patients.Plasma concentrations were measured 62 a diagnosis angina pectoris who had left ventricular ejection fraction (LVEF) >or=45% echocardiographic evaluation. Coronary performed for all patients, than...

We sought to explain the clinical importance of osteopontin (OPN) in setting acute ST-elevation myocardial infarction (STEMI).Eighty consecutive patients (55 = 11 years, 12 women and 68 men) sixty healthy control subjects were included study. In all patients, plasma OPN levels assessed on admission third day (peak value). Creatinine kinase (CK)/CK-myocardial band (MB), troponin I N-terminal pro-brain natriuretic factor echocardiographic findings also recorded. Patients classified into high...

Given that the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, can decrease bioavailability and lead to atherosclerosis, its concentration be a good predictor for coronary artery disease. In this study, we investigated relationship of plasma dimethylarginine with lesion distribution severity at angiography.Ninety-eight patients stable angina were enrolled prospectively. We divided into two groups. Group I (n=37) included normal arteries. All other in group II (n=61)....

Background Coronary artery ectasia (CAE) is a clinical entity characterized by localized or diffuse dilatation of more than equal to 1.5 times that the normal adjacent segments vessels. Although etiopathogenesis not clearly understood, some studies have shown CAE may be form atherosclerosis and has potent inflammatory properties. Leukocytes crucial role in development processes. We aimed investigate possible relationship between leukocytes coronary ectatic process without disease (CAD)...

Introduction Nitric oxide (NO) plays a major role in collateral vessel development. Asymmetric dimethylarginine (ADMA) that is an endogenous inhibitor of NO synthesis may impair the effective coronary The aim this study was to evaluate relationship between plasma ADMA level and Methods patients with greater than or equal 95% obstruction at least one epicardial artery were included study. Degree development determined according Rentrop method. Patients grade 2–3 regarded as good group formed...