A5030561488- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Regional Development and Policy
- Sleep and Wakefulness Research
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Legal Education and Practice Innovations
- Monoclonal and Polyclonal Antibodies Research
- Theater, Performance, and Music History
- Digital Games and Media
- Legal Systems and Judicial Processes
- Synthesis and Biological Evaluation
- Photoreceptor and optogenetics research
- graph theory and CDMA systems
- Cinema and Media Studies
- Receptor Mechanisms and Signaling
- Antifungal resistance and susceptibility
- Race, History, and American Society
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Fungal Infections and Studies
- Community Development and Social Impact
- Semantic Web and Ontologies
- Impact of Light on Environment and Health
University College Dublin
2024
German Cancer Research Center
2011-2023
Heidelberg University
2014-2023
University Hospital Heidelberg
2012-2023
AstraZeneca (United States)
2019-2020
Washington State University
2019
University of Saskatchewan
2019
Heidelberg University
2016
University of Oxford
2007-2012
American Historical Association
2011
Hippocampal place cells that fire together within the same cycle of theta oscillations represent sequence positions (movement trajectory) a rat traverses on linear track. Furthermore, it has been suggested encoding these and other types temporal memory sequences is organized by gamma nested oscillations. Here, we examined whether gamma-related firing permits such discrete coding. We found gamma-modulated CA1 pyramidal separated into two classes basis phases during waking periods. These...
Path integration (PI) is a highly conserved, self-motion-based navigation strategy. Since the discovery of grid cells in medial entorhinal cortex, neurophysiological data and computational models have suggested that these neurons serve PI. However, more direct empirical evidence supporting this hypothesis has been missing due to lack selective manipulations cell activity suitable behavioral assessments. Here we report disruption mice can be achieved by removing NMDA glutamate receptors from...
Abstract On the linear track, recent firing sequences of CA1 place cells recur during sharp wave/ripple patterns (SWRs) in a reverse temporal order [Foster & Wilson (2006) Nature , 440 680–683]. We have found similar reverse‐order reactivation SWRs open‐field exploration where sequence varied before each SWR. Both onset times and showed tendency for reversed SWRs. These effects were observed that occurred exploration, but not those longer immobility periods. Additionally, was stronger...
Neurons of the medial entorhinal cortex (MEC) provide spatial representations critical for navigation. In this network, periodic firing fields grid cells act as a metric element position. The location depends on interactions between self-motion information, geometrical properties environment and nonmetric contextual cues. Here, we test whether visual including cues, also regulates rate MEC neurons. Removal landmarks caused profound impairment in cell periodicity. Moreover, speed code neurons...
Efficacious use of therapeutic gene delivery via nanoparticles is hampered by the challenges associated with targeted to tissues interest. Systemic administration lipid nanoparticle (LNP)-encapsulated mRNA leads a protein expressed predominantly in liver and spleen. Here, LNP encapsulating was covalently conjugated an antibody, specifically binding plasmalemma vesicle-associated (PV1) as means target lung tissue. PV1-targeted LNPs demonstrated significantly increased lungs 40-fold...
The parasympathetic reduction in heart rate involves the sequential activation of m2 muscarinic cholinergic receptors (m(2)Rs), pertussis toxin-sensitive (Gi/o) heterotrimeric G proteins, and atrial potassium channel I(KACh). Molecular mechanisms regulating this critical signal transduction pathway are not fully understood.To determine whether protein signaling regulator Rgs6/Gβ5 modulates m(2)R-I(KACh) cardiac physiology.Cardiac expression Rgs6, its interaction with Gβ5, was demonstrated by...
Gap junctions containing connexin 36 electrically couple interneurons in many brain regions and synchronize their activity. We used connexin-36 knock-out mice ( Cx36 −/− ) to study the importance of electrical coupling between for spatial coding hippocampus different forms hippocampus-dependent memory. Recordings behaving revealed that selectivity hippocampal pyramidal neurons was reduced less stable mice. Altered network activity reflected slower theta oscillations mutants. Temporal coding,...
The activity of hippocampal pyramidal cells reflects both the current position animal and information related to its behavior. Here we investigated whether single neurons can encode several independent features defining trials during a memory task. We also tested task-related is represented by partial remapping place cell population or, instead, via firing rate modulation spatially stable cells. To address these two questions, was recorded in rats performing conditional discrimination task...
The superficial layers of the medial entorhinal cortex (MEC) contain spatially selective neurons that are crucial for spatial navigation and memory. These highly specialized include grid cells, border head-direction irregular cells. In addition, MEC display a large variability in their spike patterns at millisecond time scale. this study, we analyzed trains mice found these can be classified into two groups based on propensity to fire doublets 125–250 Hz. groups, labeled “bursty”...
The hippocampus and the parahippocampal region have been proposed to contribute path integration. Mice lacking GluA1-containing AMPA receptors ( GluA1 −/− mice) were previously shown exhibit impaired hippocampal place cell selectivity. Here we investigated whether integration performance activity of grid cells medial entorhinal cortex (MEC) are affected in these mice. We first tested mice on a standard food-carrying homing task found that they processing idiothetic cues. To corroborate...
Computational models postulate that head-direction (HD) cells are part of an attractor network integrating head turns. This requires inputs from visual landmarks to anchor the HD signal external world. We investigated whether information about and is integrated in medial entorhinal cortex parasubiculum, resulting neurons expressing a conjunctive code for landmarks. found parahippocampal could be divided into two classes based on their theta-rhythmic activity: non-rhythmic cells....
Determining the electronic phase diagram of a quantum material as function temperature (T) and applied magnetic field (H) forms basis for understanding microscopic origin transport properties, such anomalous Hall effect (AHE) topological (THE). For many materials, including EuAl$_4$, THE arises from topologically protected skyrmion lattice with non-zero scalar spin chirality. We identified square (sSkL) peak in Eu(Ga$_{1-x}$Al$_x$)$_4$ ($x$ = 0.9) identical to previously observed EuAl$_4$ by...
This paper presents a reliability assessment method for radial distribution systems. It combines, the network and customer interruption costs to form Value-Based Distribution Reliability Assessment (VBDRA) methodology, which is valuable tool system planning incorporating costs. The proposed implemented in Lotus 1-2-3 macro program with specially designed data structure network. analysis of computational shows that valid fast practical applications. Various applications VBDRA at Scarborough...
Reduction of excitatory currents onto GABAergic interneurons in the forebrain results impaired spatial working memory and altered oscillatory network patterns hippocampus. Whether this phenotype is caused by an alteration hippocampal not known because most studies employed genetic manipulations affecting several brain regions. Here we performed viral injections genetically modified mice to ablate GluA4 subunit AMPA receptor hippocampus (GluA4HC−/− mice), thereby selectively reducing...
Relay neurons in the dorsal lateral geniculate nucleus (dLGN) receive excitatory inputs from retinal ganglion cells (RGCs). Retinogeniculate synapses are characterized by a prominent short-term depression of AMPA receptor (AMPAR)-mediated currents, but underlying mechanisms and its function for visual integration not known. Here we identify CKAMP44 as crucial auxiliary subunit AMPARs dLGN relay neurons, where it increases AMPAR-mediated current amplitudes modulates gating AMPARs....
Rats with excitotoxic lesions of the dorsal or ventral hippocampus and control rats were trained on 2 spatial working memory tasks: standard version radial maze 8 baited arms non-matching-to-place procedure in T maze. Dorsal produced deficits both tasks, whereas did not affect learning either them. A volumetric analysis subicular damage showed that hippocampal caused a deficit only when accompanied by to subiculum; other hand, impaired performance radial-arm regardless extent damage.
Despite some clinical success with antibody-drug conjugates (ADCs) in patients solid tumors and hematological malignancies, improvements ADC design are still desirable due to the narrow therapeutic window of these compounds. Tumor-targeting antibody fragments have distinct advantages over monoclonal antibodies, including more rapid tumor accumulation enhanced penetration, but subject clearance. Half-life extension technologies such as PEGylation albumin-binding domains (ABDs) been widely...