A5059350548- Vibrio bacteria research studies
- Escherichia coli research studies
- Aquaculture disease management and microbiota
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Genomics and Phylogenetic Studies
- Bacteriophages and microbial interactions
- Synthesis and biological activity
- Biosensors and Analytical Detection
- Bacterial biofilms and quorum sensing
- Salmonella and Campylobacter epidemiology
- Influenza Virus Research Studies
- Oral and gingival health research
- Mycobacterium research and diagnosis
- Advanced biosensing and bioanalysis techniques
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microbial Community Ecology and Physiology
- Respiratory viral infections research
- Synthesis and Characterization of Heterocyclic Compounds
- Helicobacter pylori-related gastroenterology studies
- Viral gastroenteritis research and epidemiology
- Click Chemistry and Applications
- Eosinophilic Esophagitis
- Biodiesel Production and Applications
- Subcritical and Supercritical Water Processes
AIMST University
2013-2025
Universiti Sains Malaysia
2005-2009
University of Münster
2009
The characterization of therapeutic phage genomes plays a crucial role in the success rate therapies. There are three checkpoints that need to be examined for selection candidates, namely, presence temperate markers, antimicrobial resistance (AMR) genes, and virulence genes. However, currently, no single-step tools available this purpose. Hence, we have developed tool capable checking all conditions required suitable candidates. This consists an ensemble machine-learning-based predictors...
Staphylococcus aureus is a major human pathogen, especially methicillin-resistant S. (MRSA), which causes wide range of hospital and community-acquired infections worldwide. Conventional testing for detection MRSA takes 2–5 days to yield complete information the organism its antibiotic sensitivity pattern. The present study focused on development pentaplex PCR assay rapid MRSA. simultaneously detected five genes, namely 16S rRNA genus, fem A aureus, mec that encodes methicillin resistance,...
Chimeric antigen receptor-natural killer (CAR-NK) cell therapy is a novel immunotherapy targeting cancer cells via the generation of chimeric receptors on NK which recognize specific antigens. CAR-NK gaining attention nowadays owing to ability release potent cytotoxicity against without side effects such as cytokine syndrome (CRS), neurotoxicity and graft-versus-host disease (GvHD). do not require priming, thus enabling them be used “off-the-shelf” therapy. Nonetheless, still possesses...
Nonprotein-coding RNAs (npcRNAs) represent an important class of regulatory molecules that act in many cellular pathways. Here, we describe the experimental identification and validation small npcRNA transcriptome human malaria parasite Plasmodium falciparum. We identified 630 novel candidates. Based on sequence structural motifs, 43 them belong to C/D H/ACA-box subclasses nucleolar (snoRNAs) Cajal body-specific (scaRNAs). further observed exonization a functional H/ACA snoRNA gene, which...
Complete genomes of xenobiotic-degrading microorganisms provide valuable resources for researchers to understand molecular mechanisms involved in bioremediation. Despite the well-known ability Sphingomonas paucimobilis degrade persistent xenobiotic compounds, a complete genome sequencing is lacking this organism. In line with this, we report first sequence (strain AIMST S2), an organophosphate and hydrocarbon-degrading bacterium isolated from oil-polluted soil at Kedah, Malaysia. The was...
Vibrio cholerae has caused severe outbreaks of cholera worldwide with thousands recorded deaths annually. Molecular diagnosis for become increasingly important rapid detection as the conventional methods are time-consuming and labour intensive. However, traditional PCR tests still require cold-chain transportation storage well trained personnel to perform, which makes them user-unfriendly. The aim this study was develop a thermostabilized triplex test is in ready-to-use form requires no cold...
Parkinson's disease (PD) is a neurodegenerative disorder defined by progressive deterioration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Dental pulp stem cells (DPSCs) have been proposed to replace degenerated due its inherent neurogenic and regenerative potential. However, effective delivery homing DPSCs within lesioned brain has one many obstacles faced cell-based therapy disorders. We hypothesized that DPSCs, delivered intranasally, could circumvent these...
The global threat posed by recent respiratory viruses necessitates the development of novel antiviral agents. This study focused on design, synthesis, characterization and cytotoxicity evaluation two new coumarin analogues, 4-((5-(4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)methoxy)-2H-benzopyrone (4) N-(4-chloro-benzylidene)-2-((2H-benzopyrone-4-yl)oxy)acetohydrazide (5). These compounds were synthesized from hydrazide derivative benzopyrone (3) through reactions with 4-hydroxybenzoic acid...
Herein, we disclose earth-abundant cobalt(II) catalysed hydrogenation of nitro aromatics to amines by utilizing hydrazine hydrate as the liquid hydrogen carrier. The significant highlight this method is production...
Objectives This study examines the presence of EpsteinBarr virus (EBV) in nasopharyngeal carcinoma (NPC) by using polymerase chain reaction (PCR) Study Design Eighty‐six postnasal biopsy samples and 71 fine‐needle aspirate neck masses were obtained from patients who clinically suspect for NPC. Genomic DNA was extracted samples, EBNA1, EBNA2, LMP genes EBV detected PCR. PCR results compared with NPC histopathology findings. Results The sensitivity to detect EBNA1 (97.14%), EBNA2 (88.57%),...
To study the epidemiology of Helicobacter pylori (H. pylori) infection according to age group. H. data among 1 965 consecutive patients referred Endoscopy Unit collected at Sungai Petani Hospital for oesophagogastro-duodenoscopy (OGD). The were divided into 9 groups (10–19, 20–29, 30–39, 40–49, 50–59, 60–69, 70–79, 80–89 and 90–99 years). In addition these further three minor group namely young adults (10–39), older (40–69) geriatric (70–99). Overall prevalence was analyzed found that...
Periodontal disease (PD) is complex polymicrobial which destroys tooth-supporting tissue. Although various synthetic inhibitors of periodontitis-triggering pathogens have been recognized, their undesirable side effects limit application. Hence, the present study intended to perform synthesis, characterization, antimicrobial evaluation, and cytotoxicity analysis novel benzamidine analogues (NBA). This involved synthesis imino bases (4a-c), by reacting different aromatic aldehydes with...
Periodontal disease (PD) is multifactorial oral that damages tooth-supporting tissue. PD treatment includes proper hygiene, deep cleaning, antibiotics therapy, and surgery. Despite the availability of basic treatments, some these are rendered undesirable in due to side effects expense. Therefore, aim present study develop novel molecules combat triggering pathogens. The involved synthesis 4-((5-(substituted-phenyl)-1,3,4-oxadiazol-2-yl)methoxy)benzamidine (5a-e), by condensation...
Enterococci have emerged as a significant cause of nosocomial infections in many parts the world over last decade. The most common enterococci strains present clinical isolates are E. faecalis and faecium which acquired resistant to either gentamicin or vancomycin. conventional culture test takes 2-5 days yield complete information organism its antibiotic sensitivity pattern. Hence our study was focused on developing nanoplex PCR assay for rapid detection vancomycin bifunctional...
Next-generation transcriptome sequencing (RNA-Seq) has become the standard practice for studying gene splicing, mutations and changes in expression to obtain valuable, accurate biological conclusions. However, obtaining good coverage depth study these is impeded by difficulties of high quality total RNA with minimal genomic DNA contamination. With this mind, we evaluated performance Phenol-free purification kit (Amresco) comparison TRI Reagent (MRC) RNeasy Mini (Qiagen) extraction...
To study the prevalence of Helicobacter pylori (H. pylori) infection, according to ethnicity and gender among people Sungai Petani, Kedah, Malaysia who undergo endoscopy. epidemiology H. infection in population, we assessed database hospital admissions patients referred Endoscopy Unit at Petani Hospital for oesophagogastro-duodenoscopy (OGD) between January 2000 December 2007. For statistical analysis, Fisher's exact test (2-tailed test) was used. rate determined 1 965 consecutive patients....