A5111316373- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Nutrition, Genetics, and Disease
Princess Máxima Center
2024-2025
Malignant rhabdoid tumors are highly aggressive pediatric malignancies with limited treatment options and poor outcomes. To expand therapeutic options, we employed mass spectrometry-based cell surface proteomics on malignant tumor patient-matched normal kidney organoids to identify potential CAR T targets. Integrating these findings transcriptomics protein expression data, revealed ROBO1 as a promising target, showing strong uniform across other tumors. ROBO1-targeted cells displayed potent...
<title>Abstract</title> Malignant rhabdoid tumors are highly aggressive pediatric malignancies with limited treatment options and poor outcomes. To expand therapeutic options, we employed mass spectrometry-based cell surface proteomics on malignant tumor patient-matched normal kidney organoids to identify potential CAR T targets. Integrating these findings transcriptomics protein expression data, revealed ROBO1 as a promising target, showing strong uniform across other tumors. ROBO1-targeted...
Abstract Despite improvements in cure rates, cancer is still the leading cause of disease-related deaths among children high-income countries. As childhood cancers are rare comparison to adult cancers, concerted efforts needed advance research and improve patient care. In The Netherlands, all care most has been concentrated a single national center, Princess Máxima Center for Pediatric Oncology. institute’s centralized position enables uniform generation data from patients across country,...