A5018262230- Stellar, planetary, and galactic studies
- Nitric Oxide and Endothelin Effects
- Astronomy and Astrophysical Research
- Adenosine and Purinergic Signaling
- Ion channel regulation and function
- Cardiovascular Disease and Adiposity
- Receptor Mechanisms and Signaling
- Gamma-ray bursts and supernovae
- Cardiac electrophysiology and arrhythmias
- Epigenetics and DNA Methylation
- Infective Endocarditis Diagnosis and Management
- Nuclear Receptors and Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Adaptive optics and wavefront sensing
- Protein Structure and Dynamics
- Cardiac Fibrosis and Remodeling
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- stochastic dynamics and bifurcation
- Microtubule and mitosis dynamics
- Astronomical Observations and Instrumentation
- Ion Channels and Receptors
- Renin-Angiotensin System Studies
- Adipose Tissue and Metabolism
- Cardiovascular Issues in Pregnancy
University of Glasgow
2019-2023
Helmholtz-Zentrum Berlin für Materialien und Energie
2009
University of Auckland
2006-2007
Observations of individual massive stars, super-luminous supernovae, gamma-ray bursts, and gravitational-wave events involving spectacular black-hole mergers, indicate that the low-metallicity Universe is fundamentally different from our own Galaxy. Many transient phenomena will remain enigmatic until we achieve a firm understanding physics evolution stars at low metallicity (Z). The Hubble Space Telescope has devoted 500 orbits to observe 250 Z in ultraviolet (UV) with COS STIS...
Heart failure with preserved ejection fraction (HFpEF) is a public health problem and an elusive illness for which there are few treatment options. HFpEF systemic condition broad phenotype including diastolic dysfunction, pulmonary oedema, exercise intolerance, left ventricular (LV) hypertrophy, collectively resulting in enhanced morbidity mortality. Master-regulator transcription factor RUNX1 has recently been identified as mediator of pathological changes many cardiac diseases, however its...
Asymmetric dimethylarginine (ADMA) is generated through the irreversible methylation of arginine residues. It an independent risk factor for cardiovascular disease, currently thought to be due its ability act as a competitive inhibitor nitric oxide (NO) synthase enzymes. Plasma ADMA concentrations increase with obesity and fall following weight loss; however, it unknown whether they play active role in adipose pathology. Here, we demonstrate that drives lipid accumulation newly identified...
Strong metallicity-dependent winds dominate the evolution of core He-burning, classical Wolf-Rayet (cWR) stars, which eject both H and He-fusion products such as 14N, 12C, 16O, 19F, 22Ne 23Na during their evolution. The chemical enrichment from cWRs can be significant. cWR stars are also key sources for neutron production relevant weak s-process. We calculate stellar models at solar metallicity a range initial Helium star masses (12-50M), adopting recent hydrodynamical wind rates Sander &...
Objective: Asymmetric dimethylarginine (ADMA) is generated through the post-translational modification of arginine residues and released into cytosol following proteolysis. Elevated plasma ADMA concentration a known risk factor for cardiovascular disease due, in part, to ADMA's role as competitive inhibitor nitric oxide (NO) synthase enzymes. We have recently discovered that physiological concentrations signal via Calcium Sensing Receptor (CaSR). CaSR member family C GPCR modulated by...
Very massive stars (VMS) up to 200-300 $M_\odot$ have been found in the Local Universe. If they would lose little mass produce intermediate-mass black holes or pair-instability supernovae (PISNe). Until now, VMS modellers extrapolated mass-loss vs. metallicity ($Z$) exponents from optically-thin winds, resulting a range of PISN thresholds that might be unrealistically high $Z$, as develop optically-thick winds. We utilize transition rate Vink and Gräfener (2012) accurately predicts rates...
<h3>Objective</h3> The calcium-sensing receptor (CaSR) is a class C GPCR important in the regulation of whole body calcium homeostasis. However, CaSR expressed many tissues unrelated to handling including adipocytes and human adipose explants, where it thought regulate lipid inflammation. Given detrimental effects obesity on cardiovascular health, adipocyte may be an determinant vascular function. This study aimed characterise role vivo determine whether adipocyte-specific deletion (CaSR...
Abstract The Calcium-sensing receptor (CaSR) is a G protein-coupled activated by fluctuations in extracellular calcium concentrations. Its importance homeostasis has long been established, though its role other tissues not well understood. Obesity major epidemic with both clinical and social consequences, therefore, understanding the full function regulation of adipocytes critical importance. Adipocyte CaSR previously linked to lipolysis inflammation vitro . In this study, we set out further...
<h3>Objective</h3> The post-translational methylation of arginine residues by PRMT enzymes can yield asymmetric dimethylarginine (ADMA); which, following proteolysis is released into the cytosol and enters circulation. Elevated plasma ADMA concentrations are recognised as a risk factor for cardiovascular disease including hypertension, atherosclerosis stroke. In part, this due to acting competitive inhibitor NOS reducing NO production contributing endothelial dysfunction. However, recently...
Abstract Irreversible methylation of arginine residues generates asymmetric dimethylarginine (ADMA). ADMA is a competitive inhibitor nitric oxide (NO) synthase and an independent risk factor for cardiovascular disease. Plasma concentrations increase with obesity fall following weight loss. Here, we demonstrate that drives lipid accumulation through newly identified NO-independent pathway via the amino-acid sensitive calcium-sensing receptor (CaSR). treatment 3T3-L1 HepG2 cells activates mTOR...
The most massive stars dominate the chemical enrichment, mechanical and radiative feedback, energy budget of their host environments. Yet how initially form they evolve throughout lives is ambiguous. mass loss remains a key unknown in stellar physics, with consequences for feedback populations. In this work, we compare grids very star (VMS) models masses ranging from 80-1000Msun, range input physics. We include enhanced winds close to Eddington limit as comparison standard O-star winds,...
The ages of stars have historically relied on isochrone fitting standardised grids models. While these stellar models provided key constraints observational samples massive stars, they inherit many systematic uncertainties, mainly in the internal mixing mechanisms applied throughout grid, fundamentally undermining method. In this work, we utilise M-L plane Higgins & Vink as a method determining age, with mixing-corrected applying calibrated core overshooting alpha_ov and rotation rate to...