A5032168482- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Ocular Diseases and Behçet’s Syndrome
- SARS-CoV-2 and COVID-19 Research
- Infection Control and Ventilation
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- COVID-19 and healthcare impacts
- Connective tissue disorders research
- Infectious Aortic and Vascular Conditions
University of North Carolina at Chapel Hill
2019-2021
Beaumont Health
2020
University of North Carolina Health Care
2019
University Hospitals of Cleveland
2014
BackgroundAlthough the risk of exposure to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is higher for frontline healthcare workers, not all personnel have similar risks. Determining infection rate difficult due limits on testing and high asymptomatic individuals. Detection antibodies against SARS-CoV-2 may be useful determining prior virus assessing mitigation strategies, such as isolation, masks, other protective equipment.
Background Thoracic aortic aneurysms (TAAs) occur because of abnormal remodeling extracellular matrix and are accompanied by the emergence proteolytically active myofibroblasts. The microRNA miR-133a regulates cellular phenotypes is reduced in clinical TAA specimens. This study tested hypothesis that modulates fibroblast phenotype, overexpression lentivirus attenuates development a murine model. Methods Results was induced mice. Copy number tissue linear regression analysis confirmed an...
Rationale: Thoracic aortic aneurysms (TAA) result from dysregulated remodeling of the vascular extracellular matrix, and may occur as altered resident cellular phenotype. MicroRNA-133a is reduced in clinical TAA specimens plays an inhibitory role regulation pathological phenotypic switch cells. Accordingly, this study tested hypothesis that miR-133a replacement attenuates development TAA. Methods Results: was induced wild type mice (0.5M CaCl 2 application, 15 minutes). Following 4 weeks,...