A5045265157- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Ferroptosis and cancer prognosis
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal disorders and treatments
- Cancer, Lipids, and Metabolism
- Gallbladder and Bile Duct Disorders
University of Florida Health Science Center
2024
University of Florida Health
2024
University of Florida
2019-2023
Washington University in St. Louis
2023
Florida College
2023
Abstract Introduction: Due to the heterogeneity of hepatocellular carcinoma (HCC), incidence resistance and toxicity first-line therapy sorafenib is high. Combinations drugs can be used exploit synergistic effects reduce adverse events, while improving efficacy survival. In-vitro studies performed by our team identified irinotecan sonidegib have potential for therapeutic in combination with sorafenib. Follow up in-vivo dose optimization a murine NASH induced HCC found this 3-drug more...