Background: Patients who undergo surgical procedures that impair the integrity of chest wall frequently experience extremely severe postoperative pain. Opiates and weaker analgesics, such as nonsteroidal anti-inflammatory drugs (NSAIDs), are not sufficiently effective in achieving control pain might cause respiratory gastrointestinal complications. In past decade, there has been an increased interest use regional nerve blocks for post-thoracoscopy post-thoracotomy analgesia. Methods: This is...

Background Decreasing blood glutamate concentrations after traumatic brain injury accelerates brain-to-blood efflux, leading to improved neurologic outcomes. The authors hypothesize that treatment with scavengers should reduce neuronal cell loss, whereas administration of worsen performed histologic studies survival in the rat hippocampus and scavengers. Methods Traumatic was induced on anesthetized male Sprague-Dawley rats by a standardized weight drop. Intravenous groups included saline...

Treatment with oxaloacetate after traumatic brain injury has been shown to decrease blood glutamate levels and protect against the neurotoxic effects of on brain. A number potential mechanisms have suggested explain oxaloacetate-induced neuroprotection. We hypothesize that primary mechanism by which intravenous provides neuroprotection is activation glutamate-scavenging enzyme glutamate-oxaloacetate transaminase, increasing thereby driving force for efflux excess from interstitial fluids...

Excessive concentrations of L-glutamate (glutamate) have been found to posses neurotoxic properties. This study investigates how stress induced by strong physical exercise effects blood glutamate, 2-ketoglutarate, Alanine aminotransferase (ALT) and Aspartate Aminotransferase (AST) levels. The relationship between muscle damage caused glutamate levels was also examined. Twenty-two healthy volunteers engaged in intense veloergometry (“spinning”) for a duration 60 minutes. Two 10 minute peaks...

Depression is a common and serious complication following traumatic brain injury (TBI). Both depression TBI have independently been associated with pathologically elevated extracellular glutamate levels. In the setting of TBI, blood scavenging pyruvate has widely shown as an effective method to provide neuroprotection by reducing subsequent Here we evaluate novel approach in treatment prevention post-TBI depression-like behavior rat model. Rats were divided into five groups: (1)...

Background: Isoflurane-anesthetized rats subjected to traumatic brain injury (TBI) show a transient reduction in blood L-glutamate levels. Having previously observed that isoproterenol produces sustained decrease glutamate levels naive rats, we investigated the possible effects of nonselective and selective β1 β2 adrenergic agonists antagonists both on neurological outcomes TBI. Methods: Rats received either 10 mL/kg isotonic saline 1 hour after TBI, 50 µg/kg pretreatment 30 minutes before...

Patients undergoing abdominal oncologic surgical procedures require particular and anesthesiologic considerations. Traditional pain management, such as opiate treatment, continuous epidural analgesia, non-opioid drugs, may have serious side effects in this patient population. We evaluated erector spinae plane (ESP) blocks for postoperative management following elective surgeries. In single-center, prospective, randomized study, we recruited 100 patients who underwent oncological surgery...

In Brief INTRODUCTION: Glutamate neurotoxicity is determined by the balance between glutamate release within brain and efflux of excess from brain. Brain-to-blood increased decreasing concentration in blood. Little known about effect hyperthermia on blood concentrations, effectiveness glutamate–decreasing mechanisms these conditions. Although hypothesized to decrease concentrations activation stress mechanisms, blunting response blocking β-adrenergic receptors should prevent this decrease....

Post-stroke depression (PSD) is the most recurrent of all psychiatric complications resulting from an ischemic stroke. A greater majority (about 60%) stroke patients suffer PSD, a disorder considered to be stroke-related precursor for increased death and degradation in health. The pathophysiology PSD still obscure. To study mechanism development occurrence further, find out therapy, we attempted develop new protocol that requires occluding middle cerebral artery (MCA) via internal carotid...

Purpose: Neuropathic, chronic pain is a common and severe complication following thoracic surgery, known as post-thoracotomy syndrome (PTPS). Here we evaluated the efficacy of an ultrasound-guided serratus anterior plane block (SAPB) on control compared to traditional management with intravenous opioids nonsteroidal anti-inflammatory drugs (NSAIDs) six months after surgery. Patients Methods: In this retrospective observational study, analyzed data from questionnaire survey. We interviewed...

The Aintree intubating catheter (Cook® Medical Inc., Bloomington, IN, USA) has been shown to successfully facilitate difficult intubations when other methods have failed. a fixed length of 56 cm, and it suggested in the literature that may be too short for safe use patients who are tall.We present case 32-year-old, 180 cm tall Caucasian woman with predicted airway presented our facility an emergency cesarean section. After several failed intubation attempts via direct laryngoscopy, was...

Boyko, M.; Gruenbaum, S. E.; B. F.; Dubilet, Zlotnik, A. Author Information

Introduction: We present a case of 37-yearold female who suffered an iatrogenic tear the trachea following non-traumatic intubation for uncomplicated, elective cesarean section under general anesthesia. Case Report: Fifty minutes after extubation, patient developed hemodynamic instability and respiratory distress, which required reintubation, was surgically repaired. Tracheal rupture is rare but potentially life-threatening lesion, delay in diagnosis treatment associated with poor outcome....

Several motor-function scales have been developed to assess neurological function in animal models of stroke, subarachnoid hemorrhage and closed head injury. We hypothesize that the location arterial venous catheters, even absence brain injury, may impact rats' motor performance. Our study examined effect catheter location, rate infection time required for placement. further describe an original technique tail artery cannulation without exposure artery. Sixty-one rats were anesthetized...

Impairments to sensory, short-term, and long-term memory are common side effects after traumatic brain injury (TBI). Due the ethical limitations of human studies, animal models provide suitable alternatives test treatment methods, study mechanisms related complications condition. Experimental rodent have historically been most widely used due their accessibility, low cost, reproducibility, validated approaches. A metric test, which tests ability recall placement two objects at various...

Objective: This retrospective cohort study aimed to investigate postoperative pain levels and analgesic drug requirements in women who underwent GA or SA during vaginal pelvic floor surgeries. Design: A study. Participants/Materials, Setting, Methods: Women aged 18 above surgery between 2019 2021 were included the Univariate multivariate analyses performed separately for wall repair stress urinary incontinence surgery. Results: During period, 101 under SA, 99 GA. Intravenous analgesia...

Post-stroke depression (PSD) is the most recurrent of all psychiatric complications resulting from an ischemic stroke. A greater majority (about 60%) stroke patients suffer PSD, a disorder considered to be stroke-related precursor for increased death and degradation in health. The pathophysiology PSD still obscure. To study mechanism development occurrence further, find out therapy, we attempted develop new protocol that requires occluding middle cerebral artery (MCA) via internal carotid...

For many species, where status is a vital motivator that can affect health, social hierarchies influence behavior. Social include dominant-submissive relationships are common in both animal and human societies. These be affected by interactions with others their environment, making them difficult to analyze controlled study. Rather than simple dominance hierarchy, this formation has complicated presentation allows rats avoid aggression. Status stagnant or mutable, results complex societal...