A5079616575- Trauma and Emergency Care Studies
- Appendicitis Diagnosis and Management
- Abdominal Trauma and Injuries
- Trauma Management and Diagnosis
- Disaster Response and Management
- Cardiac Arrest and Resuscitation
- Traumatic Ocular and Foreign Body Injuries
- Traumatic Brain Injury and Neurovascular Disturbances
- Hernia repair and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Bariatric Surgery and Outcomes
- Cancer Genomics and Diagnostics
- Injury Epidemiology and Prevention
- Intraperitoneal and Appendiceal Malignancies
- Pelvic and Acetabular Injuries
- Traffic and Road Safety
- Adenosine and Purinergic Signaling
- Genetic factors in colorectal cancer
- Traumatic Brain Injury Research
- Pancreatitis Pathology and Treatment
- Immune Response and Inflammation
- Gastroesophageal reflux and treatments
- Abdominal Surgery and Complications
- Intestinal and Peritoneal Adhesions
- Diverticular Disease and Complications
Soroka Medical Center
2008-2024
Ben-Gurion University of the Negev
2011-2023
Örebro University
2023
Sheba Medical Center
2020
Tel Aviv University
2018-2020
Israel National Institute for Health Policy Research
2016-2019
University Medical Center
2010-2018
University Hospital and Clinics
2018
Marymount University
2005
Hebrew University of Jerusalem
1997
Elevated circulating cell-free DNA (CFD) levels were found in patients with cancer. The standard CFD assays are work-intensive and expensive. aim was to evaluate cancer a new simple assay. In mice inoculated cells, correlated tumor size. Compared healthy subjects, 38 colorectal (CRC) had higher preoperative (798 ± 409 vs 308 256 ng/mL; P < .0001). free of disease at 1 year, elevated who remained or died (DD). DD (P = .033), combined index carcinoembryonic antigen × exhibited better...
Abstract Objectives: To evaluate circulating cell-free DNA (CFD) measured by a simple fluorescent assay as biomarker of breast cancer. Methods: We enrolled 38 patients with cancer before surgery, two noncancerous lesions, nine after 16 healthy participants, and 29 control women admitted to the hospital emergency ward released without hospitalization. CFD levels were direct fluorescence assay. Results: Presurgery had elevated (1,010 ± 642 ng/mL), which higher than those in group (395 248...
Injury patterns are closely related to changes in behavior. Pandemics and measures undertaken against them may cause behavior; therefore, injury during the coronavirus disease 2019 (COVID-19) outbreak can be expected when compared parallel period previous years.The aim of this study was compare injury-related hospitalization overall national lockdown with periods years.A retrospective completed all patients hospitalized from March 15 through April 30, for years 2016-2020. Data were obtained...
Background Ketamine is an anesthetic drug. Subanesthetic doses of ketamine have been shown to reduce interleukin-6 concentrations after surgery and mortality the production tumor necrosis factor alpha interleukin 6 in septic animals. Similarly, adenosine was The aim this study determine whether mediates antiinflammatory effects ketamine. Methods Sepsis induced mice by lipopolysaccharide or Escherichia coli inoculation. Leukocyte recruitment cytokine were used as inflammation markers....
BackgroundAdenosine levels rise during inflammation and modulate inflammatory responses by engaging with four different G protein-coupled receptors. It is suggested that adenosine exhibits pro-inflammatory effects through its A1 receptor (A1R), anti-inflammatory A2A (A2AR). Therefore, understanding of the mechanisms govern regulation may advance treatment various disorders. We previously reported peak A1R expression leukocyte recruitment, followed a in A2AR resolution.Principal FindingsHere,...
The gonadal steroids estrogen and progesterone have been shown to neuroprotective properties against various neurodegenerative conditions. Excessive concentrations of glutamate found exert neurotoxic properties. We hypothesize that provide neuroprotection by the autoregulation blood brain levels. Venous samples (10 ml) were taken from 31 men 45 women determine glutamate, estrogen, progesterone, glucose, glutamate-pyruvate transaminase (GPT), glutamate-oxaloacetate (GOT) levels, collected on...
ABSTRACT Background: Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) may improve Systolic Blood Pressure (SBP) in hypovolemic shock. It has, however, not been studied patients with impending traumatic cardiac arrest (ITCA). We aimed to study feasibility and clinical outcome REBOA ITCA using data from ABOTrauma Registry. Methods: Retrospective prospective on use 16 centers globally were collected. SBP was measured both at pre- post-REBOA inflation. Data collected included...
ABSTRACT The morbidity and mortality caused by diabetic foot ulcer (DFU) are still significant. Conservative treatment of DFU is often ineffective. Treatment modalities using stem cells directly into the or systematically have been introduced recently. Ischemic preconditioning (IPC) has proved to be a cheap, simple, safe method which can augment number in peripheral blood circulation. This study's purpose was test whether IPC improve healing. Forty patients were enrolled divided study...
Ketamine was reported to decrease cytokine production and improve survival after Escherichia coli-induced sepsis. We examined whether ketamine decreased interleukin (IL)-6 improved 1) burn injury or 2) combined with sepsis (E. coli) at 24 h. (10 mg/kg) saline given 1 h (G 1, 2, 5, 6), 3, 4), E. coli inoculation 7, 8). Mortality recorded for 7 days IL-6 measured in serum 6 1-2), 30 3-4), (30 burn) 5-8). Burn only: immediately (1 h) but not after, the burn-induced increase of did survival. +...
Oral drug bioavailability may be significantly altered after laparoscopic sleeve gastrectomy (LSG), the most popular bariatric procedure worldwide. Paracetamol (acetaminophen) is post-bariatric analgesic/antipyretic of choice. In this work we studied and analyzed LSG effects on systemic pharmacokinetics paracetamol oral administration solid vs. liquid dosage form. A 4-armed, pharmacokinetic, crossover trial was performed in patients enrolled for LSG. Single dose (500 mg), as caplet (n = 7)...
Tyrosine kinase-dependent cell signaling is postulated to be a pivotal control point in inflammatory responses initiated by bacterial products and TNF. Using canine model of gram-negative septic shock, we investigated the effect tyrosine kinase inhibitors (tyrphostins) on survival. Animals were infected intraperitoneally with Escherichia coli 0111: B4, then, randomized, blinded fashion, treated immediately one two tyrphostins, AG 556 (n = 40) or 126 10), 50), followed for 28 d until death....
Abnormally high concentrations of glutamate in brain fluids have been shown to be neurotoxic and correlate with a poor neurological outcome following traumatic injury (TBI). Since fluid can reduced by scavenging blood glutamate, the purpose this study was investigate factors that may potentially influence levels glucose, enzymes glutamate-pyruvate transaminase (GPT) glutamate-oxaloacetate (GOT) healthy individuals.Factors were examined included age, gender, time last meal or drink, recent...
Background . Despite great advances in the treatment of burn patients, useful prognostic markers are sparse. During past years there has been increasing interest circulating plasma cell free DNA as a potential marker for tissue injury. We have developed rapid direct fluorescent assay quantification that allows obtaining accurate, fast, and inexpensive measurements. Objective To use this technique measuring levels patients to further explore patient outcome burns. Methods Cell obtained from...
Traumatic brain injury (TBI) is a major cause of death and disability. In this study new method to measure cell free DNA (CFD) for the management TBI tested. Our hypothesis was that CFD concentrations correlate magnitude damage, may predict outcome injured patients. Twenty eight patients with isolated head were enrolled. Their demographic clinical data recorded. levels determined in patients' sera samples by direct fluorescence developed our laboratory. Mean admission values lower mild...
According to the World Health Organization, over one million people die annually from traffic crashes, in which half are pedestrians, bicycle riders and two-wheel motor vehicles. In Israel, during last decade, mortality crashes has decreased 636 1998 288 2011. Professionals attribute decrease enforcement, improved infrastructure roads behavioral changes among road users, while no credit is given trauma system. Trauma systems care for severe critical casualties improve injury outcomes reduce...
Aim: To assess the incidence and injury characteristics of hospitalized trauma patients diagnosed with TBI.Methods: A retrospective study all injured recorded in National Trauma Registry at 19 centres Israel between 2002–2011. Incidence were examined among children, adults seniors.Results: The annual rate TBI for Israeli population 2011 was 31.8/100 000. Age-specific highest seniors a dramatic decrease TBI-related mortality them. Adults, comparison to children seniors, had higher rates...
Investigation of injury patterns epidemiology among car occupants may help to develop different therapeutic approach according the seat position. The aim study was evaluate and compare differences in incidence serious injuries, between locations private cars. A retrospective including trauma patients who were involved motor vehicle accidents admitted alive 20 hospitals (6 level Ⅰ centers 14 Ⅱ centers). We examined injures with abbreviated score 3 more, compared their occurrence locations....
In contrast to an emergency department of thoracotomy (EDT), urgent (UT) is defined as a surgical thoracic intervention performed in the operating room within first 48 hours patient's intensive care unit (ICU) stay. The factors affecting survival after UT are not fully understood. this study, we retrospectively analyzed clinical data and outcome patients with blunt penetrating chest injuries who underwent UT.All adult had or trauma UT, were included study. All collected from patients'...
Objectives: Liver rupture and hematoma are rare life-threatening complications of pregnancy. The aims the current study to: (1) characterize in a population-based all cases liver and/or rupture; (2) validate utility International Society on Thrombosis Haemostasis (ISTH) modified pregnancy specific disseminated intravascular coagulation (DIC) score those cases.Study design: A retrospective cohort including patients with subcapsular or between years 1996 2012 was conducted. Information...