A5018203602- Mitochondrial Function and Pathology
- Hormonal and reproductive studies
- Mass Spectrometry Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Metabolism and Genetic Disorders
- Epigenetics and DNA Methylation
- High Altitude and Hypoxia
- Sirtuins and Resveratrol in Medicine
- Microstructure and Mechanical Properties of Steels
- Metal Forming Simulation Techniques
- Muscle metabolism and nutrition
- RNA Research and Splicing
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Metabolomics and Mass Spectrometry Studies
- Composite Material Mechanics
- Viral Infectious Diseases and Gene Expression in Insects
- Nuclear Structure and Function
- Genetics and Physical Performance
Laboratory of Racing Chemistry
2021-2024
Tokyo Metropolitan University
1990-2020
Toshiba (Japan)
1990
Keihin (Japan)
1990
Mitochondrial disorders have the highest incidence among congenital metabolic characterized by biochemical respiratory chain complex deficiencies. It occurs at a rate of 1 in 5,000 births, and has phenotypic genetic heterogeneity. Mutations about 1,500 nuclear encoded mitochondrial proteins may cause dysfunction energy production disorders. More than 250 genes that been reported to date. However exact diagnosis for patients still remained largely unknown. To reveal this heterogeneity, we...
In the context of doping control, conventional direct chemical testing detects only a limited scope target substances in equine biological samples. To expand ability to detect agents and their detection windows, metabolomics has recently become common approach for monitoring alteration biomarkers caused by relevant metabolic pathways. horse racing, remarkable changes profiles between rest state racing are likely affect identification biomarkers. Previously, we reported number significantly...
Tetratricopeptide repeat protein 37 (TTC37) is a causative gene of trichohepatoenteric syndrome (THES). However, little known about the pathogenesis this disease. Here, we characterize phenotype Drosophila model in which ski3, homolog TTC37, disrupted. The mutant flies are pupal lethal, and lethality partially rescued by transgenic expression wild-type ski3 or human TTC37. larvae show growth retardation, heart arrhythmia, triacylglycerol accumulation, aberrant metabolism glycolysis TCA...
The abuse of prohibited peptide-based drugs with a broad spectrum chemical characteristics poses significant concern for the horseracing industry. Recently, there has been notable increase in positive cases small-peptide reported equine and canine sports. In addition to small peptides, large peptides (over 2 kDa) structural diversity have also entered market increasing numbers as humans livestock. However, simultaneous analysis both small- large-peptide-based is still challenging. this...
The abuse of prohibited peptide-based drugs with a broad spectrum chemical characteristics poses significant concern for the horseracing industry. Recently, there has been notable increase in positive cases small-peptide reported equine and canine sports. In addition to small peptides, large peptides (over 2 kDa) structural diversity have also entered market increasing numbers as humans livestock. However, simultaneous analysis both small- large-peptide-based is still challenging. this...